TYPE 1 DIABETES

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This study tested a new closed-loop system that automatically delivers both insulin and pramlintide to manage blood sugar in 33 adults with type 1 diabetes. Pramlintide slows digestion to prevent blood sugar spikes after meals. The system was compared to insulin alone. Researcher…

This study tested a new fully-closed insulin delivery system that automatically adjusts insulin based on activity and missed meals, compared to a standard hybrid system. 29 adults with type 1 diabetes used both systems to see which kept blood sugar in a healthy range more often. …

This study tested whether adding a smart, AI-powered insulin boost before meals could improve blood sugar control in adults with type 1 diabetes. Nineteen participants used either a standard automated insulin system or the same system with the AI boost during hotel stays and at h…

This study tested whether oat flakes containing β-glucan, a type of fiber, could help adolescents aged 12–18 with type 1 diabetes improve their blood sugar control, pancreatic function, and cholesterol levels. Sixty participants were randomly assigned to eat the oat flakes or a c…

This study tested whether a class of diabetes drugs called SGLT2 inhibitors can slow the progression of kidney disease in adolescents with type 1 diabetes. Researchers measured changes in urine protein levels and blood sugar control over 6 months in 86 participants aged 10-18. Th…

This study tested whether giving insulin as an extended bolus (over time) instead of all at once helps control blood sugar after high-fat, high-protein meals in teens with type 1 diabetes. Thirty teens using a closed-loop insulin pump ate a standardized breakfast and received eit…

This study tested a new self-learning bolus calculator that simplifies meal announcements for adolescents and young adults with type 1 diabetes using automated insulin delivery. Two participants used the system first in a hotel and then at home to see if it was safe and feasible.…

This study tested whether eccentric training (a type of exercise that lengthens muscles) done in a low-oxygen (hypoxic) chamber or with creatine supplements could improve blood sugar control, muscle strength, and fitness in people with type 1 diabetes. 28 adults with type 1 diabe…

This study followed 30 adults with type 1 diabetes who used the Smartguard system, a partially automated insulin pump that can pause insulin delivery when it predicts a low blood sugar. The goal was to see how well the system works in everyday life, focusing on time spent in the …

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested whether a serious computer game called DIVE helps children aged 10-17 with newly diagnosed type 1 diabetes learn about their disease. 78 kids played the game twice a week for at least an hour, covering topics like diet and treatment. Researchers measured their k…

This study tested whether sending supportive text messages to teenagers with poorly controlled type 1 diabetes could help lower their blood sugar levels. 92 teens aged 12-21 with high HbA1c levels participated. The approach used mobile phone reminders to encourage better diabetes…

This completed trial tested whether a faster-acting insulin (Lyumjev) used with a special conversion factor in an automated insulin pump (Control-IQ) could improve blood sugar control in 11 adolescents with type 1 diabetes. Participants were randomly assigned to use Lyumjev with …

This study tested whether using a very tight glucose target (80-99 mg/dL) in an advanced hybrid closed-loop insulin pump (CamAPS FX) improves blood sugar control in adults with type 1 diabetes who had poor control. Forty participants who previously used multiple daily injections …

This study tested whether a faster-acting insulin (Fiasp) works better than standard rapid insulin (NovoRapid) in insulin pumps for children and teens with type 1 diabetes. Researchers looked at blood sugar levels 30 minutes, 1 hour, and 2 hours after meals using real-world data …

This phase 2 trial tested whether infusions of PROCHYMAL, a stem cell product, could safely help people recently diagnosed with type 1 diabetes. The study enrolled 63 participants aged 12–35 who had been diagnosed within the past 20 weeks. Researchers measured how well the pancre…

This study followed 410 people with type 1 diabetes who use closed-loop insulin pumps—devices that automatically adjust insulin delivery. Researchers measured how well these pumps control blood sugar over time using HbA1c levels. The goal was to see if the pumps work effectively …

This small pilot study tested whether transplanting pancreatic islets together with parathyroid glands into the muscle could help people with type 1 diabetes stop using insulin. The 4 participants already had a functioning kidney or liver transplant and were on lifelong immunosup…

This study tested a program called FAM that helps adults with type 1 diabetes avoid dangerously high blood sugar, which can lead to diabetic ketoacidosis (DKA). The program involved sharing real-time glucose data with a family member or friend (the Follower), creating an action p…

This study compared time-restricted eating (eating only during a 6-8 hour window each day) to daily calorie restriction for weight loss and blood sugar control in 32 adults with type 1 diabetes and obesity. Participants followed their assigned diet while continuing insulin and gl…

This study tested whether a faster-acting insulin (Lyumjev) works better than standard insulin (Humalog) in a dual-hormone artificial pancreas for people with type 1 diabetes. Twelve adults who already used the artificial pancreas took part. Each person used both insulins for 30 …

This study tested whether combining text message reminders with small rewards (behavioral economics) could help 173 teens with type 1 diabetes take their insulin more consistently. Participants used an insulin pump and had a history of missing mealtime doses. The goal was to impr…

This study tested a new insulin patch pump in 161 adults with type 1 or type 2 diabetes who needed intensive insulin therapy. Participants used either the new patch pump or a standard pump for 7 days in a hospital. Researchers measured changes in average blood sugar levels to see…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This study tested the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 system, an automated insulin pump, in 48 people aged 2 to 70 with type 1 or type 2 diabetes. The system uses a continuous glucose monitor to automatically adjust insulin delivery. The main goals were …

This study looked at whether a low-carbohydrate diet could help children and teens (ages 10-18) with type 1 diabetes manage their blood sugar better. Twenty-five participants followed the diet for a short time, and researchers measured their blood glucose levels. The goal was to …

This study tested whether a sleep coaching program could help young adults (ages 18-26) with type 1 diabetes sleep longer and improve their blood sugar levels. Participants received personalized sleep advice and weekly check-ins over several weeks. The goal was to see if better s…

This study tested whether combining two safe immune therapies—abatacept injections and nasal insulin—can help preserve the pancreas's ability to make insulin in people recently diagnosed with type 1 diabetes. The goal is to make blood sugar control easier and reduce the need for …

This study looked at whether alerts from continuous glucose monitors (CGMs) help hospital patients with type 1 or 2 diabetes manage their blood sugar better. Over 500 adults who needed intensive insulin therapy took part. The main goal was to see if alerts increased the time bloo…

This pilot study tested whether shared medical appointments (group visits) could help underserved children aged 8–12 with poorly controlled type 1 diabetes. The 14 participants attended group visits every 3 months for a year, focusing on using diabetes technology and improving bl…

This study tested two versions of an artificial pancreas in 15 adults with type 1 diabetes. One version used only insulin with automatic carb suggestions, while the other added glucagon to prevent low blood sugar. Participants underwent exercise and meal challenges to see which s…

This study compared a new version of the Omnipod insulin pump (SmartAdjust 2.0) to the current Omnipod 5 in 132 people with type 1 or type 2 diabetes, ages 2 to 70. Participants used each system for about a month to see if the new one is safe and helps keep blood sugar in a healt…

This Phase 3 trial tested a new fast-acting insulin called THDB0206 against a standard insulin (lispro) in 550 Chinese adults with type 1 diabetes. Both groups also used a long-acting insulin (glargine). The main goal was to see if THDB0206 could control blood sugar (HbA1c) as we…

This study tested whether trained peer mentors (ages 20-35) could help young adults (ages 17-25) with type 1 diabetes better control their blood sugar and smoothly move from pediatric to adult diabetes care. 144 participants were randomly assigned to receive peer support or usual…

This study tested a mobile app called Diactive-1 that guides children and teens with type 1 diabetes through resistance exercises like squats and band pulls. Over 24 weeks, researchers tracked whether the app helped lower daily insulin doses. The trial enrolled 62 participants ag…

This study looked at how well an artificial pancreas system (the Tandem t:slim pump with Control-IQ Technology) works for teenagers with Type 1 Diabetes during puberty. It followed 42 adolescents aged 11-13 for two years, comparing the device to usual care. The goal was to see if…

This study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Fourteen participants received up to three infusions of donor islet cells along with steroid-free immunosuppression. The goal was to see …

This study tested an automated insulin delivery system (the Omnipod 5) in 130 hospitalized adults with type 1 or type 2 diabetes. Patients were randomly assigned to use the automated system or standard insulin injections plus a continuous glucose monitor. The goal was to see if t…

This early-phase trial tested the safety of a new drug called R-5280, a modified starch, in 9 children aged 11-17 who were recently diagnosed with type 1 diabetes. The study compared R-5280 to a placebo (food-grade starch) and monitored side effects and blood sugar levels over 12…

This study tested a connected insulin management platform in 36 people with type 1 or type 2 diabetes who use insulin. The goal was to see if the platform helped them take their insulin doses on time and keep their blood sugar in a healthy range. Participants used a continuous gl…

This study looked at whether the MiniMed 780G insulin pump, when used with a continuous glucose monitor, is safe for children aged 2 to 6 years with type 1 diabetes. Fifty-six children used the system at home. The main goals were to measure how often their blood sugar stayed in a…

This study tested the Omnipod 5, an automated insulin delivery system, against standard insulin pumps in 196 adults with type 1 diabetes. Participants used their usual therapy for 14 days, then either switched to Omnipod 5 or stayed on their pump for 90 days. The goal was to see …

This pilot study tested an artificial intelligence system that helps manage insulin delivery in young children (ages 2 to 6) with type 1 diabetes. The system combines a continuous glucose monitor, an insulin pump, and an AI advisor that adjusts pump settings automatically. Thirty…

This completed Phase 4 trial enrolled 400 youth aged 7-25 with type 1 diabetes in low-resource settings. It compared insulin glargine (a long-acting analogue) to standard human insulin (NPH or premixed) to see if glargine reduces serious hypoglycemia or improves time in blood sug…

This study tested a new feature for automated insulin delivery systems: a priming bolus that automatically delivers a small amount of insulin before a meal. The goal was to see if it helps keep blood sugar in a healthy range after eating. Fifteen adults with type 1 diabetes parti…

This study tested a weekly injection of semaglutide (a drug used for type 2 diabetes and weight loss) in 115 adults with type 1 diabetes and obesity who already use an automated insulin pump. The goal was to see if adding semaglutide helps improve blood sugar levels, reduce hypog…

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This study tested a program called T1DES designed to help Black young adults aged 18-30 with type 1 diabetes feel less stressed about their condition. Researchers wanted to see if the program was practical and could improve blood sugar levels and emotional well-being. The study i…

This study tested a smart technology platform with a serious game for 200 adolescents with type 1 diabetes. The game was designed to help them build emotional and social skills, cope with their condition, and improve quality of life. Researchers measured changes in well-being, em…

This completed study tested a behavioral program for 217 teens and young adults (ages 14-25) with type 1 diabetes. The program included 12 one-on-one sessions focused on improving blood sugar levels and reducing diabetes-related distress. Researchers measured changes in time in r…

This study tested a program where community health workers helped young adults (ages 18-35) from underrepresented minority groups with type 1 diabetes start using devices like continuous glucose monitors and insulin pumps. Over 9 months, 119 participants were randomly assigned to…

This study tested whether adding a 12-week home-based high intensity interval training program to standard education about preventing low blood sugar (hypoglycemia) helps adults with type 1 diabetes who have lost the ability to sense low blood sugar. 47 participants were randomly…

This study tested whether regular nurse counseling could help teenagers with type 1 diabetes feel more in control of their condition and improve their blood sugar levels. 77 teens aged 13-18 with poorly controlled diabetes took part. One group received routine care, while the oth…

This study looked at whether exercising before or after lunch is better for controlling blood sugar in women with type 1 diabetes, including those who are pregnant. Twenty women participated, and researchers measured how much time their blood sugar stayed in a healthy range over …

This study tested three different programs to help adults with type 1 diabetes manage the stress and worry that often comes with the condition. 296 participants were split into groups, each trying a different approach: one focused on emotional awareness, another on problem-solvin…

This study tested a mobile app that gives personalized encouragement and health insights based on blood sugar, exercise, mood, and sleep patterns. The goal was to help 24 middle-aged adults with type 1 diabetes or similar conditions exercise more often and confidently. The app ai…

This completed study tested a behavioral program called ONBOARD for 150 adults with type 1 diabetes who were not using continuous glucose monitors regularly. The program taught skills to overcome common barriers like managing data and social situations. The goal was to help parti…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This completed study looked at 238 people who received a pancreas and kidney transplant for type 1 diabetes. The goal was to understand why diabetes sometimes returns even after a new pancreas is working. Researchers checked for immune system markers, like antibodies and T cells,…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study tested a digital program that monitors both the emotional well-being of caregivers and the glucose levels of children with type 1 diabetes. Thirty families used the system for two months to see if it was practical and easy to use. The goal was to learn how stress and b…

This study looked at whether people with severe, long-term uncontrolled type 1 diabetes would accept and benefit from a closed-loop insulin delivery system (an 'artificial pancreas'). Researchers followed 66 adults with very high blood sugar levels over several years. The goal wa…

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 people with and without diabetes to understand why fitness levels may be lower in those with high blood …

This study tested a new way to help young adults (ages 18-30) with type 1 or type 2 diabetes move from pediatric to adult diabetes care. Researchers compared a collaborative care model to usual care, looking at how many visits patients completed and changes in diabetes-related di…

This study looked at whether cutting basal insulin by half before exercise helps keep blood sugar stable in people with type 1 diabetes. Eighteen active adults using insulin pumps completed two treadmill sessions—one with the insulin reduction and one without. Researchers measure…

This completed study looked at how two substances—GIP, a natural gut hormone, and alanine, an amino acid from protein—work together to release glucagon, a hormone that raises blood sugar. Researchers tested 10 people with and without type 1 diabetes to see if combining GIP and al…

This completed study looked at why people with type 1 diabetes lose their natural defense against low blood sugar—the hormone glucagon. Researchers tested whether blocking a hormone called GLP-1 with a drug (exendin(9-39)amide) could restore glucagon release during low blood suga…

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This study looked at how eating disorders, like anorexia or bulimia, impact blood sugar levels in women with type 1 diabetes. Researchers compared glucose control between those with and without eating disorders. The goal was to better understand these risks and improve screening …

This study tested a questionnaire that measures nutrition knowledge in Turkish adolescents with type 1 diabetes. Researchers enrolled 150 teens to see if the tool is reliable and valid. The goal is to help future studies and improve diabetes care by linking nutrition knowledge to…

This study checked how well children with type 1 diabetes and their brothers or sisters follow the recommended vaccination schedule. Researchers looked at vaccination records from 60 children. The goal was to see if kids with diabetes are up to date on their shots, not to test a …

This study looked at whether giving oral glucose at a slightly higher blood sugar threshold can prevent mild-to-moderate hypoglycemia in people with type 1 diabetes. Thirty adults with type 1 diabetes were given 16g of oral carbohydrates when their blood glucose reached a target …

This study looked at how automated insulin delivery (AID) systems, including homemade DIY versions, perform in physically active adults with type 1 diabetes. Over six weeks, 76 participants wore their own AID systems and a fitness tracker while sharing glucose and insulin data. T…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study tested whether people with diabetes can use a smartphone game to monitor their vision at home, instead of always going to the clinic. 55 participants at high risk for diabetic retinopathy played vision games on their phones for 6 months. The goal was to see if people w…

This study looks at whether using an automated insulin delivery system (a smart insulin pump and continuous glucose monitor) along with a low-carbohydrate diet can help restore the body's natural glucagon response to low blood sugar in people with type 1 diabetes. The glucagon re…

This study measured how common post-traumatic stress disorder (PTSD) is in adults with type 1 diabetes, focusing on PTSD related to the initial diabetes diagnosis or a severe hypoglycemic event. Researchers gave 297 participants questionnaires to check for PTSD symptoms. The goal…

This completed study looked at 825 adults with type 1 diabetes who use an insulin pump to see how many also have obstructive sleep apnea. Researchers used overnight oxygen tests and sleep studies to find cases. The goal was to understand if sleep apnea is linked to diabetes compl…

This study looks at how pancreas-kidney transplantation changes bile acids and gut-related metabolism in people with type 1 diabetes and kidney disease. Researchers will measure bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transp…

This study looked at 62 people with type 1 diabetes to see if a test that measures the hormone glucagon can predict the risk of dangerously low blood sugar (hypoglycemia). Participants drank a special liquid meal or received an arginine injection to stimulate glucagon release, an…

This study followed 512 children born to parents with type 1 diabetes to see if early immune system changes and other factors could predict who might develop the disease. Researchers looked at blood markers, gut bacteria, and family environment. The goal was to better understand …

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study looked at whether immune cell responses can serve as a simpler way to measure how many insulin-producing beta cells remain in people with type 1 diabetes. Researchers followed 156 participants over 30 months, using meal tests and blood/urine samples. The goal was to fi…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study tested whether it is possible to run diabetes education workshops for inmates at Paris' La Santé prison. 22 men with type 1 or type 2 diabetes took part in group classes covering diet, foot care, and medication. The main goal was simply to see if prisoners would attend…

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study tested a mobile app designed to help young people with type 1 diabetes learn how to manage their condition. Twenty teens aged 10-18 used the app at home for 12 weeks. Researchers measured how often they used the app and checked their blood sugar control.

This study from Yale University looked at what happens when teenagers with type 1 diabetes follow a very low carbohydrate diet for two weeks. Nineteen participants ate either a low-carb or standard diet to see how it affected their blood sugar levels and brain function. The goal …

This study looked at how stress, anxiety, and depression affect daily diabetes care in teens and young adults (ages 13-26) with type 1 diabetes. Participants used their smartphones to answer quick surveys throughout the day while wearing a continuous glucose monitor. The goal was…

This early study tests whether the antidepressant fluoxetine (Prozac) can improve the body's nervous system response during exercise in people with type 1 diabetes. Many with diabetes avoid exercise due to fear of low blood sugar. The study includes 64 adults—half with type 1 dia…

This study compares two versions of insulin lispro—one standard strength and one double-strength—to see if they work the same in the body. About 90 adults with type 1 diabetes will receive a single dose of each in random order. The goal is to check if the stronger formula is bioe…

This study tested whether an online peer support group on Discord is helpful and easy to use for teens aged 16-19 with type 1 diabetes. Ten participants joined the group for 3 months and gave feedback. The main goal was to see if teens would use it and like it, not to measure blo…

This study looked at whether oxytocin, a natural hormone, can improve the body's ability to release glucagon during low blood sugar (hypoglycemia) in people with type 1 diabetes. Sixteen adults with type 1 diabetes received both oxytocin and a placebo on separate days to compare …