Could blocking GLP-1 restore the Body's natural defense against low blood sugar?
NCT ID NCT07373236
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at why people with type 1 diabetes lose their natural defense against low blood sugar—the hormone glucagon. Researchers tested whether blocking a hormone called GLP-1 with a drug (exendin(9-39)amide) could restore glucagon release during low blood sugar. Twelve adults with type 1 diabetes took part, receiving either the blocker or a placebo. The goal was to see if this mechanism works in humans, which could lead to new treatments to reduce hypoglycemia risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- exendin(9-39)amide (a GLP-1 blocker)
- What this could lead to
- If successful, this could point toward a new add-on treatment to insulin therapy that lowers the risk of dangerously low blood sugar in type 1 diabetes.
- What could go wrong
- This is a very small, early-stage study (12 people) testing a mechanism, not a treatment. Results may not lead to a usable therapy, and the blocker itself may have side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Gentofte Hospital
Hellerup, 2100, Denmark
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