TYPE 1 DIABETES

This study will look at whether a remote patient monitoring system, called Steno Detektor, helps people with diabetes control their blood sugar. About 12,000 patients will be monitored as part of their regular care. Researchers will compare blood sugar levels and hospital visits …

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This study tests a new automated insulin delivery system for people with type 1 or type 2 diabetes in a hospital setting. Six participants will have their blood sugar controlled by the system for 24 hours while eating standard meals. The goal is to see if the system can keep bloo…

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study will test whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and nutrition. About 80 participants will be randomly assigned to CGM-guided care or stand…

This study looks at whether starting an automated insulin delivery (AID) system within two weeks of a type 1 diabetes diagnosis helps young patients manage their blood sugar more easily. Sixteen youth newly diagnosed with type 1 diabetes will be offered the system and followed fo…

This study tests a new drug called IMC-S118AI in people with type 1 diabetes who have a specific genetic marker (HLA-A*02:01). The main goal is to check if the drug is safe and how it works in the body. Researchers will also look at whether it can help preserve the cells that mak…

This study looks at whether starting automated insulin delivery (AID) early in children aged 7–16 with type 1 diabetes improves blood sugar control, reduces stress for patients and families, and prevents long-term complications compared to standard insulin injections. One hundred…

This study follows 40 adults with type 1 diabetes who previously used an automated insulin delivery system. Researchers want to see if the system's benefits, like better blood sugar control, last for years. They will also check if long-term use leads to weight gain.

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This phase 2 trial tests whether the cancer drug sorafenib can help people newly diagnosed with type 1 diabetes keep making their own insulin. Ten adults aged 18-60 will receive either sorafenib or a placebo daily, along with their usual insulin. The study measures changes in ins…

This pilot study will test whether a multi-domain program—including psychological support, diet changes, targeted therapy, and parent counseling—can improve thinking skills and behavior in 50 children (ages 6-16) with Type-1 diabetes who have hypoglycemia unawareness (not feeling…

This study will test a new experimental automated insulin delivery system (called NMX8) in 116 people with type 1 or type 2 diabetes who need insulin. The goal is to see if the new system is safe and works as well as the current Medtronic 780G system at keeping blood sugar in a h…

This study tests whether an activity book called 'Think-Find-Solve' can improve insulin self-management in children aged 8-12 with type 1 diabetes. Forty children and their parents will take part, with one group using the book for three months. The goal is to see if the book help…

This study tests whether individualized video consultations can help adults with type 1 diabetes manage exercise and blood sugar more confidently. Sixty participants will receive up to three 30-minute sessions with a doctor or exercise specialist. The goal is to improve self-mana…

This study tests an 8-week mindfulness program for people with type 1 or type 2 diabetes who have trouble sensing when their blood sugar drops too low. The program teaches body awareness techniques like mindful eating and body scanning to help patients catch early warning signs. …

This study tests whether a color-coded rotation training program helps people with diabetes improve their insulin self-management skills. Researchers will teach 112 participants how to rotate injection sites and change needles using a colorful chart and a mannequin. The goal is t…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study tests a 10-session online program called REDCHiP for parents of young children (up to age 8) with type 1 diabetes. The program uses cognitive behavioral therapy to help parents manage their fear of hypoglycemia (low blood sugar) and reduce diabetes-related distress. Ab…

This study aims to identify newborns with a high genetic risk of developing type 1 diabetes. Researchers will screen 50,000 infants using a simple genetic test to find those with a greater than 10% risk. The goal is not to treat diabetes, but to find eligible babies for future pr…

This pilot study will test how easy it is for 20 adults with diabetes to set up and use the Feetsee foot monitoring device at home over 8 weeks. Participants will use the device and app on their own, following the instructions provided. The goal is to see if people can use it cor…

This study looks at whether it's possible to screen children for type 1 diabetes during their regular well-child visits. Researchers will ask parents and doctors about their experience with the screening and track how many families complete the test. The goal is to find the best …

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at whether a new tool helps young adults (ages 18-30) with type 1 diabetes and their doctors work together better to make care plans that fit daily life. Researchers will compare usual doctor visits with visits using the tool, and interview participants afterward…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This study aims to understand how insulin deprivation and high blood sugar affect protein synthesis in muscles and blood of people with type 1 diabetes. Researchers will use muscle biopsies and special amino acid labels to track protein production. The study involves 70 participa…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young people aged 15-24 with type 1 diabetes. Researchers will measure blood vessel function before and after drinking a sweetened sports drink. The goal is to under…

This study will test how well two continuous glucose monitors (Dexcom One Plus and FreeStyle Libre 2 Plus) work in pregnant women with diabetes. About 66 women will wear both devices at the same time to see which is more accurate. The study also looks at what women know about dia…