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Scientists target GLUT1 to tame immune attacks in type 1 diabetes

NCT ID NCT07695727

Not yet recruiting Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study investigates whether blocking GLUT1, a protein that helps immune cells use sugar, can reduce the autoimmune attack that destroys insulin-producing cells in type 1 diabetes. Researchers will analyze stored blood samples from adults with type 1 diabetes and test immune cells in mice. The goal is to understand if changing how immune cells process sugar could lead to new treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this research could point toward a new way to calm the immune system in type 1 diabetes without lifelong drugs.
What could go wrong
This is an early lab study using stored blood samples, not a human treatment trial. Results may not translate to real-world therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNITY TYPE 1 DIABETES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • IRCCS San Raffaele Scientific Institute

    Milan, 20132, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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