Irccs San Raffaele

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. It includes 311 participants aged 40 and older with favorable tumor types. The goal is to see if the one-time treatment controls cancer just…

This study tests a combination of ibuprofen, G-CSF, and plerixafor to collect stem cells from people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder. The goal is to see if this drug mix is safe and effective at gathering enough stem cells for future ge…

This study is testing a new digital platform that uses simple, non-invasive tools like EEG, eye-tracking, and blood flow sensors to find early signs of Alzheimer's disease. It will include 100 people aged 55 to 80, some with mild memory problems and some healthy. The goal is to c…

This study compares a new type of CT scanner (photon-counting CT) to MRI for finding liver tumors that have spread from colorectal cancer. About 100 adults with colorectal cancer will get both scans, and researchers will check if the new CT is as good as MRI at detecting these tu…

This study tests whether combining two types of scans—PET and MRI—into one exam can more accurately detect serious prostate cancer while avoiding unnecessary biopsies for low-risk cases. About 167 men with suspected prostate cancer will receive the combined scan before their biop…

This study is checking if a blood test for a protein called S100B can tell doctors whether a person with a head injury has a brain injury or not. The test is very good at ruling out brain injury, which could help avoid unnecessary CT scans and shorten emergency room visits. About…

This study tests a home-based virtual reality program to help people with multiple sclerosis improve hand and arm movement. Participants watch, imagine, and then perform hand tasks guided by VR. The study involves 60 adults with MS and lasts 3 weeks. Researchers will also use bra…

This study tests whether virtual reality-based exercises can reduce neck pain and improve daily function in people with chronic neck pain or whiplash. About 72 adults will be randomly assigned to either VR-enhanced rehabilitation or the same exercises without VR. The goal is to s…

This study tests whether mild electrical stimulation to the brain and spine can boost the effects of walking and balance exercises in people with Parkinson's disease who have trouble with falls and unsteady gait. About 71 participants (51 with Parkinson's and 20 healthy volunteer…

This study is for adults with interstitial lung disease (ILD), a chronic lung condition that often affects the heart. Researchers will use advanced CT scans to look at both the lungs and heart in detail, searching for early signs of heart damage that are usually missed. The goal …

This study is building a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular information to identify differences in how the disease presents in women. The goal is to better understand these variations …

This study aims to improve how doctors decide on treatment for small kidney tumors (up to 4 cm). Researchers will combine MRI scans with detailed analysis of tumor tissue samples (biopsies) to see if they can better predict which tumors are aggressive. The goal is to help match e…

This study will use artificial intelligence to check for hidden spine fractures in CT scans of the chest and abdomen that were done for other medical reasons. Researchers want to see how common these fractures are in men aged 50 and older who do not have known bone diseases. The …

This study is creating a large collection of medical images and health information from 50,000 adults undergoing advanced CT or MRI scans. Researchers will analyze these images to find hidden patterns that could improve how we prevent, diagnose, and treat diseases like cancer, he…

This study looks at whether CT scans can be used to check heart tissue health, similar to how MRI does now. MRI is the current best method but has limits—it can't be used in people with certain devices, takes a long time, and can't see the heart's arteries. CT scans are faster an…

This study is looking for new ways to tell which pancreatic cysts (called IPMNs) are cancerous and which are harmless. Right now, many people have surgery to remove cysts that turn out to be benign, which can lead to complications. Researchers will study blood, fluid, and tissue …

This study is testing a gel called PuraBond that helps stop bleeding during open surgery on the main artery in the belly. About 100 adults having this surgery will be watched to see how quickly the gel works. The goal is to learn if PuraBond can make surgery safer and faster.

This study is looking for better ways to diagnose endometriosis and adenomyosis, two conditions that can cause pain and fertility problems. Researchers will collect blood and fluid samples from 530 women, including those with these conditions and those seeking fertility treatment…

This study looks at genetic differences and certain blood markers in people with Menière's disease, a condition that causes severe dizziness and hearing problems. Researchers will compare these factors with those in people who have vestibular migraine and healthy individuals. The…

This study is gathering detailed information from 625 people with colorectal or pancreatic cancer that has spread to the liver, as well as from healthy volunteers. Researchers will analyze tumor and blood samples to understand how the immune system interacts with these cancers. T…

This study tracks how people with advanced lung cancer feel during their first treatment. About 144 participants will fill out online questionnaires about their quality of life, symptoms, mood, sleep, and sexual health before treatment, after 4 and 8 cycles, and when the disease …

This study aims to create a large national collection of blood samples and medical data from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze the complete genetic code of participants to find rare gene changes that may cause or contribute …

This study will follow 1000 adults with low vitamin D who are taking supplements. Researchers will collect health data over 10 years to see how vitamin D use relates to conditions like heart disease, diabetes, cancer, and osteoporosis. The goal is to learn more about risk factors…

This study is a registry that will collect information from up to 10,000 adults with esophageal problems like GERD, achalasia, or other motility disorders. Participants will undergo standard tests such as manometry and pH monitoring. The goal is to gather data to improve understa…

This study looks at medical records from 1000 adults to understand how bones, muscles, and energy use are linked. Researchers will analyze blood and urine markers to see how they change with age and sex. The goal is to learn more about these connections, not to test a new treatme…

This study is a registry that collects information from 100 people with deep vein disease in the legs. Researchers will track treatments and outcomes over 10 years to learn which approaches work best. The goal is to provide evidence that helps doctors make better treatment decisi…

This study looks at whether ultrasound can detect scarring (fibrosis) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from colonoscopies to develop new, non-invasive ways to measure disease. The goal is to improve diagn…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, or bone infections. Researchers will track their symptoms, lab results, and treatments over time, and store biological samples for future research. The goal i…

This study looks at how pancreatic cancer changes over time in people receiving chemotherapy. Researchers will take small tissue samples from the tumor at two different times to see if the cancer's genetic type shifts. The goal is to better understand how the cancer evolves, not …

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three standard procedures—surgery, a stent placed by endoscopy, or a newer EUS-guided bypass—to see which one helps patients eat better, tolerate chemotherapy, and maintain nu…

This study looks at how things like age, sex, tumor grade, and location affect how well treatments work for people with well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NENs). Researchers will track 450 adults who have received standard therapies like somatos…