Irccs San Raffaele

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. The goal is to see if the one-time treatment controls cancer just as well while reducing side effects and visits. Participants must be 40 or…

This phase II trial tests whether a combination of ibuprofen, G-CSF, and plerixafor can safely and effectively mobilize stem cells from the bone marrow into the blood in people with X-linked chronic granulomatous disease (X-CGD). Only 3 adults aged 18-45 are being enrolled. The g…

This study will test whether an AI program can find vertebral fractures (broken spine bones) that might be missed on CT scans done for other reasons. Researchers will look at scans from 250 men aged 50 or older to see how common these fractures are. The goal is to improve detecti…

This study tests whether combining two types of scans (PET and MRI) before a prostate biopsy can more accurately find serious prostate cancers while avoiding unnecessary biopsies for low-risk cancers. About 167 men with suspected prostate cancer will receive the combined scan, an…

This study is testing a digital platform that uses EEG, eye-tracking, and blood flow sensors to detect early signs of Alzheimer's in people with mild cognitive impairment. Researchers will follow 100 participants aged 55–80 for 12 months to find markers that predict progression t…

This study tests whether a new type of CT scanner (photon-counting CT) can detect liver metastases from colorectal cancer as well as MRI does. About 100 adults with colorectal cancer will get both scans, and researchers will compare the results. If the new CT works well, it could…

This study is testing whether a blood test for a protein called S100B can help doctors quickly rule out brain injury in people who come to the emergency room with a head injury. The test is already known to be very accurate at predicting when no brain injury is present. If it wor…

This study tests whether virtual reality exercises can reduce neck pain and disability better than standard physical therapy. Seventy-two adults with chronic neck pain or whiplash will do 12 sessions over six weeks. Half will use VR, the other half will do the same exercises with…

This study tests whether a home-based virtual reality program can help people with multiple sclerosis improve hand function. 60 participants will either watch and imitate hand tasks in VR or watch landscapes before doing the same tasks. The program lasts 3 weeks with daily sessio…

This study tests whether adding gentle electrical stimulation to the brain and spine can improve walking and balance training for people with Parkinson's disease who have trouble with gait. About 71 participants (51 with Parkinson's and 20 healthy controls) will take part. The Pa…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study will follow 1,000 adults who are taking vitamin D supplements for low vitamin D levels. Researchers will collect health data over 10 years to see how vitamin D use relates to conditions like heart disease, diabetes, cancer, and osteoporosis. The goal is to learn more a…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This study aims to understand why liver metastases are so deadly in colorectal and pancreatic cancers. Researchers will analyze tumors and blood from 625 participants to find new targets for immune and gene therapies. The goal is to develop better treatments for these hard-to-tre…

This study is creating a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular data to understand how symptoms and disease patterns may vary among women. The goal is to identify subtypes of heart disease…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This study is creating a national biobank of blood samples and health data from 230 people with Parkinson's disease or a related sleep disorder (REM sleep behavior disorder). Researchers will analyze the complete DNA of each participant to find rare genetic changes that may cause…

This study is testing a gel called PuraBond that helps stop bleeding during open surgery on the main artery in the belly. About 100 adults with an enlarged or blocked abdominal aorta will take part. The goal is to see how quickly the gel controls bleeding after the artery is uncl…

This study is looking for better ways to decide on treatment for small kidney tumors (up to 4 cm). Researchers will combine MRI scans with detailed analysis of tumor tissue samples to see if they can predict which tumors are aggressive. The goal is to help doctors choose the best…

This study looks at medical records from 1000 adults to understand how bones, muscles, and energy use are linked. Researchers will analyze blood and urine markers to see how they change with age and sex. The goal is to learn more about these connections, not to test a new treatme…

This study is testing whether a CT scan can do the same job as an MRI for looking at heart muscle damage and scarring. MRI is the current gold standard but is slow, expensive, and not suitable for everyone (e.g., people with pacemakers or claustrophobia). The researchers will enr…

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three procedures—surgery, a metal stent placed by endoscopy, and a newer ultrasound-guided stent—to see which helps patients eat better, maintain weight, and tolerate chemothe…

This study looks at how factors like age, sex, tumor grade, and location influence how well treatments work for people with well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Researchers will follow 450 patients to see how long their disease stays und…

This study will use advanced CT scans to look at both the lungs and heart in people with interstitial lung disease (ILD). The goal is to find early signs of heart problems, which are common but often missed until serious. Researchers hope to create better ways to predict and mana…

This study is creating a huge collection of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain disorders. Part…

This study looks at how pancreatic cancer changes over time in people receiving chemotherapy. Researchers take small tissue samples from the tumor at diagnosis and again after treatment to see if the cancer's genetic type has shifted. The goal is to better understand how the canc…

This study explores whether ultrasound and elastography can detect fibrosis (scarring) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from biopsies to find new biomarkers. The goal is to develop a non-invasive method t…

This study is looking for new biomarkers to tell which pancreatic cysts (IPMNs) are likely to become cancerous. Researchers will analyze genetic, metabolic, and lifestyle data from 800 patients to develop a risk score. The goal is to help doctors decide who truly needs surgery an…

This observational study is recruiting 530 women to better understand endometriosis and adenomyosis. Researchers will analyze genetic, epigenetic, and imaging data, using artificial intelligence to develop better diagnostic tools. The goal is to enable earlier detection and more …

The European Venous Registry (EVeR) is collecting data from 100 patients with deep vein disease in the legs to track how different treatments work over 10 years. Researchers will measure symptoms and quality of life to find out which approaches are most effective. This is an obse…

This study looks at whether asking patients with advanced lung cancer to fill out regular questionnaires about their quality of life, symptoms, and mental health can help doctors understand which treatment works best. About 144 people will complete online surveys before, during, …