Irccs San Raffaele

This study tests a combination of ibuprofen, G-CSF, and plerixafor to collect stem cells from people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder. The goal is to see if this drug mix is safe and effective at gathering enough stem cells for future ge…

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. It aims to see if the one-time treatment is just as effective at preventing the cancer from coming back. Participants must be 40 or older wi…

This study is checking if a blood test for a protein called S100B can tell doctors whether a person with a head injury has a brain injury or not. The test is very good at ruling out brain injury, which could help avoid unnecessary CT scans and shorten emergency room visits. About…

This study tests whether combining two types of scans (PET and MRI) before a prostate biopsy can more accurately find serious prostate cancer while avoiding unnecessary biopsies for low-risk cases. About 167 men with suspected prostate cancer will receive the combined scan, and r…

This study is building a digital platform that uses simple, non-invasive tools like brain wave sensors, eye-tracking, and blood flow monitors to catch early signs of Alzheimer's disease. Researchers will follow 100 adults aged 55–80 with mild memory problems and compare them to h…

This study compares a new type of CT scanner (photon-counting CT) to MRI for finding liver tumors that have spread from colorectal cancer. About 100 adults with colorectal cancer will get both scans, and researchers will check if the new CT is as good as MRI at spotting small tum…

This study tests whether doing neck exercises with virtual reality (VR) can reduce pain and disability better than the same exercises without VR. About 72 adults with long-term neck pain or whiplash will take part in 12 sessions over 6 weeks. Researchers will measure changes in p…

This study tests whether mild electrical stimulation to the brain and spine can boost the effects of walking and balance exercises in people with Parkinson's disease who have trouble with falls and unsteady gait. About 71 participants (51 with Parkinson's and 20 healthy volunteer…

This study tests whether watching and imitating hand movements in virtual reality at home can improve hand dexterity in people with multiple sclerosis. Sixty adults with MS and right-hand weakness will do 15 sessions over 3 weeks. One group watches hand actions; the other watches…

This study is gathering detailed information from 625 people with colorectal or pancreatic cancer that has spread to the liver, as well as from healthy volunteers. Researchers will analyze tumor and blood samples to understand how the immune system interacts with these cancers. T…

This study tracks how people with advanced lung cancer feel during their first treatment. About 144 participants will fill out online questionnaires about their quality of life, symptoms, mood, sleep, and sexual health before treatment, after 4 and 8 cycles, and when the disease …

This study aims to create a large national collection of blood samples and medical data from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze the complete genetic code of participants to find rare gene changes that may cause or contribute …

This study watches 100 adults having open surgery for a bulging or blocked abdominal aorta. Doctors use a gel called PuraBond to help stop bleeding from stitches. The goal is to measure how quickly bleeding stops after the gel is applied. This is an observational study, not a tes…

This study looks at how often men over 50 have spine fractures that were not found before. Researchers will use a special AI program to check CT scans of the chest and belly that were done for other reasons. The goal is to see if AI can help find these hidden fractures, which are…

This study will use CT scans to look for scarring and other changes in the heart muscle of 2,200 adults who already need a heart CT for medical reasons. The goal is to see if these CT findings can help predict who might later be hospitalized for heart failure or die. The research…

This study will follow 1000 adults with low vitamin D who are taking supplements. Researchers will collect health data over 10 years to see how vitamin D use relates to conditions like heart disease, diabetes, cancer, and osteoporosis. The goal is to learn more about risk factors…

This study aims to find new markers in blood, fluid, and tissue that can better predict which pancreatic cysts (IPMNs) are likely to become cancer. Researchers will analyze samples from 800 adults with IPMNs, including those who had surgery and those under monitoring. The goal is…

This study looks at how genes and certain body chemicals (like interleukins) may play a role in Menière's disease, a condition that causes severe vertigo. Researchers will compare 250 people with Menière's disease to those with vestibular migraine and healthy volunteers. The goal…

This study aims to see if a special, low-dose CT scan can better detect both lung and heart problems in people with interstitial lung disease (ILD). Heart issues are common in ILD but often missed until they become serious. By scanning 123 adults with ILD, researchers hope to cre…

This study looks at whether ultrasound can detect scarring (fibrosis) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from colonoscopies to develop new, non-invasive ways to measure disease. The goal is to improve diagn…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, or bone infections. Researchers will track their symptoms, lab results, and treatments over time, and store biological samples for future research. The goal i…

This study is a registry that collects information from 100 people with deep vein disease in the legs. Researchers will follow participants for up to 10 years to see how different treatments affect symptoms and quality of life. The goal is to gather evidence to help doctors make …

This study is building a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic and biological information to better understand how heart disease differs among women. The goal is to identify subtypes that could lead to more personal…

This study looks at how pancreatic cancer changes over time in people receiving chemotherapy. Researchers will take small tissue samples from the tumor at two different times to see if the cancer's genetic type shifts. The goal is to better understand how the cancer evolves, not …

This study looks at medical records from 1,000 adults to understand how bones, muscles, and energy use are linked. Researchers will analyze blood and urine markers to see how they change with age and sex. The goal is to learn more about these connections, not to test a new treatm…

This study looks at endometriosis and adenomyosis, two chronic conditions that affect women's reproductive health. Researchers will collect blood and fluid samples from 530 women to study genes, epigenetics, and ultrasound images, using AI to find better ways to diagnose these co…

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three standard procedures—surgery, a stent placed by endoscopy, or a newer EUS-guided bypass—to see which one helps patients eat better, tolerate chemotherapy, and maintain nu…

This study is creating a massive database of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns, or 'signatures,' that could help predict, diagnose, and treat diseases like cancer, heart conditions, and…

This study is looking for 50 adults with small kidney tumors (up to 4 cm) who are scheduled for surgery. Researchers want to see if combining MRI scans with detailed analysis of tumor tissue (biopsies) can better predict which cancers are aggressive. The goal is to improve how do…

This study looks at how things like age, sex, tumor grade, and location affect how well treatments work for people with well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NENs). Researchers will track 450 adults who have received standard therapies like somatos…

This study is a registry that will gather information from up to 10,000 adults with esophageal problems like GERD, achalasia, or swallowing difficulties. Researchers will collect data from standard tests such as manometry and pH monitoring to better understand these conditions. T…