Irccs San Raffaele

This study tests a personalized radiation therapy plan for people with locally advanced rectal cancer. The goal is to increase the chance of completely eliminating the tumor before surgery from 41% to 70%. Researchers will use a special score (ERI_TCP) to select patients who may …

This study tests a very precise type of radiation called stereotactic body radiotherapy (SBRT) for people with kidney cancer who cannot have surgery. The goal is to see if this treatment can control the tumor while causing fewer side effects. About 60 participants will receive on…

This study will enroll 110 first-time mothers who give birth vaginally to compare how well a standard finger exam (digital rectal exam) and a new machine learning-assisted electrical impedance spectroscopy device (ONIRY system) detect obstetric anal sphincter injuries. Both metho…

This study tests two new CT scan methods to find dangerous blockages in heart arteries without needing invasive procedures. About 142 adults with moderate artery narrowing will get advanced scans to see if these techniques can accurately identify which blockages reduce blood flow…

This study tests whether a special sheath that suctions away debris during kidney stone surgery helps remove more stones and lowers infection risk compared to the standard sheath. About 134 adults with kidney stones will be randomly assigned to one of the two devices. The main go…

This study tests whether a high-calorie, high-protein nutritional drink with added immune-supporting nutrients can lower the risk of serious side effects in people with advanced gastrointestinal cancers receiving their first systemic treatment. About 88 participants will be rando…

This study tests if a gentle heat treatment applied inside the vagina can calm overactive bladder symptoms. The heat targets nerve endings in the bladder muscle to reduce sudden urges and leakage. The study will include 48 adults with moderate to severe symptoms and measure impro…

This study tests a device called VTone that uses gentle electrical pulses inside the vagina to strengthen muscles and reduce accidental urine leakage when coughing, sneezing, or exercising. Fifteen women with stress urinary incontinence will receive 8 weekly treatments and be fol…

This observational study will follow 40 adults with thymic abnormalities or MG-related antibodies to understand how myasthenia gravis develops and progresses. Participants will undergo clinical exams, blood tests, and tissue analysis (if surgery is needed) over 18 months. The goa…

This study tests a new AI method that could create one type of brain scan (FDG PET) from another (amyloid PET) using existing data from 35 Alzheimer's patients. If successful, future patients might only need one scan instead of two, reducing radiation, cost, and time. No new scan…

This study aims to find better ways to monitor how well antibody treatments for early Alzheimer's are working. Instead of relying on expensive PET scans, researchers will use advanced MRI and blood tests to build personalized models that predict when a patient's brain has cleared…

This study uses blood samples from 100 healthy volunteers to test how different machine settings (suction strength and cutting speed) affect cell survival during a simulated eye surgery procedure. The goal is to find the settings that keep the most cells intact, which could help …

This study will track 2,500 adults in Italy who are getting an endoscopic ultrasound (EUS) because their doctor suspects a pancreatic or bile duct tumor. Researchers want to see how often the biopsy from the scope gives the right diagnosis, how safe the procedure is, and how quic…

This study measures how much of the antibiotic delafloxacin gets into the blood and infected tissues of 20 adults with serious skin, bone, or joint infections. Participants continue their prescribed treatment while researchers collect blood samples and small tissue samples during…

This study compares walking patterns between 50 people with gait disorders and 50 healthy volunteers using small body sensors and muscle activity monitors. Participants wear sensors on their legs and trunk while walking 18 meters. The goal is to identify key differences in joint …

This study looks at 200 people with inherited retinal diseases like retinitis pigmentosa and Stargardt disease. Researchers will review past eye exams and genetic tests to see how vision changes over time and how different genes affect the disease. The goal is to better understan…

This study will follow 500 cancer patients receiving immunotherapy to better understand and manage immune-related side effects (irAEs). Researchers will collect data on symptoms, lab tests, and treatments to find patterns that predict who gets side effects and how to handle them …

This study will test whether a modified ultrasound technique can accurately measure inflammation in people with moderate-to-severe ulcerative colitis. About 25 adults starting a new medication will get both ultrasound and colonoscopy exams over 24 weeks. If ultrasound proves reli…

This study looks at whether a special ultrasound score, called OTUS, can help doctors monitor disease activity in people with Takayasu arteritis, a rare condition that causes inflammation in large arteries. About 100 adults with active disease will have regular ultrasounds during…

This study will test a new, non-invasive eye scanner (wide field OCTA) in 200 adults with various eye diseases like age-related macular degeneration, diabetic retinopathy, and uveitis. The goal is to see if this device provides better images of blood vessels in the back and front…

This study will collect and analyze brain scans (CT/MRI) and medical records from over 1,100 adults with cerebrovascular disease. The goal is to better understand how different types of brain imaging findings relate to patients' symptoms. This knowledge may help doctors diagnose …

This study explores whether teens with celiac disease have more disordered eating behaviors than healthy teens. About 300 adolescents aged 11-17 will fill out questionnaires about their eating habits, and a smaller group newly diagnosed with celiac disease will be followed for tw…

This study looks at children born after a genetic test called PGT, which involves taking a few cells from an embryo. Researchers want to see if this biopsy affects the child's growth during the first year of life. About 330 children and their mothers will take part, answering que…

This study will test whether combining PET and MRI scans with a special amino acid tracer can more accurately diagnose brain tumors and tell if treatments are working. It involves 270 adults with primary or secondary brain tumors, but does not add any extra procedures beyond stan…

This study follows 50 adults with neuromyelitis optica spectrum disorder (NMOSD) who appear stable on standard treatment. Researchers will use blood tests and MRI scans to look for signs of hidden damage that could predict future relapses or disability. The goal is to better unde…

This study will collect health information from 10,000 adults with diabetes, metabolic disorders, or related conditions like high blood pressure and fatty liver. Researchers will track patients over at least 10 years to find better ways to diagnose, monitor, and treat these disea…

This study looks at whether combining simple tests—handgrip strength, electrical body scans, and thigh ultrasound—can help doctors spot rapid muscle loss (acute sarcopenia) in older adults admitted to the hospital. Researchers will follow 280 patients aged 65 and older to find ou…