New study aims to replace costly PET scans with MRI and blood tests for Alzheimer's patients
NCT ID NCT07456462
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study will test whether advanced MRI scans and blood tests can predict how well Alzheimer's patients respond to antibody drugs like lecanemab and donanemab. Researchers aim to create personalized models that show when amyloid plaques have been cleared from the brain, potentially replacing expensive PET scans. Fifty participants with early Alzheimer's will be followed for 18 months to see if these non-invasive methods can guide treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- monoclonal antibodies (lecanemab or donanemab)
- What this could lead to
- If successful, this could lead to a safer, cheaper way to monitor Alzheimer's treatment and decide when to stop medication, tailored to each patient.
- What could go wrong
- This is a small, early-stage study with only 50 participants, so results may not apply to everyone. The models are still being developed and may not accurately predict treatment response.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
San Raffaele Neurology Unit
Milan, Milano, 20132, Italy
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