Brain scans could unlock the hidden timeline of Alzheimer's
NCT ID NCT07758660
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study uses PET imaging to measure two key proteins in the brain—amyloid and tau—that are hallmarks of Alzheimer's disease. Researchers will follow 120 participants over five years, including people with normal aging, mild cognitive impairment, and dementia, to see how these protein levels change over time. The goal is to better understand the progression of Alzheimer's and potentially improve early detection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PET imaging tracers: 18F-MK6240 (for tau) and 18F-Florbetaben (for amyloid)
- What this could lead to
- If successful, this could improve early detection and tracking of Alzheimer's disease, potentially leading to better diagnostic tools and treatment monitoring.
- What could go wrong
- This is an observational imaging study, not a treatment trial, so it won't directly test a therapy. The results may not immediately change clinical practice, and the imaging techniques may have limitations in accuracy or generalizability.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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