MILD COGNITIVE IMPAIRMENT (MCI)

This study tests an experimental oral drug called KDS2010 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. Participants take either a low dose, a higher dose, or a placebo daily for 24 weeks. Researchers measure changes in memory, thinking, an…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can improve thinking skills, mood, and walking ability in older adults who have mild cognitive impairment and depression. Participants, aged 65 to 90, will be randomly ass…

This study tests a drug called NPC-1 (made of two natural compounds) in 40 adults aged 55+ with early Alzheimer's, mild cognitive impairment, or subjective memory concerns. The goal is to see if it safely changes blood markers linked to Alzheimer's brain changes. Participants tak…

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow disease progression by blocking a process linked to Alzheimer's. A…

This study follows 120 people with early Alzheimer's or mild cognitive impairment who are taking lecanemab, an FDA-approved drug that targets amyloid plaques in the brain. Researchers will track changes in memory, daily function, and brain scans over 18 months to see if the drug …

This study is testing whether blood tests can help screen for Alzheimer's disease in older adults during routine check-ups. Researchers will enroll 3,000 people aged 60-80 from communities and clinics. Participants will give blood samples, and those with abnormal results will tak…

This study investigates whether a supplement made from hydroxytyrosol-rich olive juice, combined with a Mediterranean diet, can help prevent cognitive decline in people with mild cognitive impairment (MCI). Participants aged 50 to 85 with MCI will receive either a low or high dos…

This study explores whether rhythmic auditory stimulation (like a metronome beat) can improve walking and brain function in people with Alzheimer's disease or mild cognitive impairment. Participants will walk while listening to rhythmic sounds, and researchers will measure change…

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve memory and thinking in people with mild cognitive impairment. Forty participants will receive either real or fake light sessions for 12 weeks. Researchers will measure brain acti…

This study tests a 5-week virtual cognitive training program for people aged 65-85 with mild cognitive impairment (MCI). Participants attend weekly two-hour group sessions online, learning memory strategies, mindfulness, and planning skills. Researchers want to see if the shorter…

This early-stage study is testing whether a supplement called gamma glutamylcysteine (GGC) is safe for people with mild cognitive impairment (MCI), a condition that can lead to memory loss. Nine volunteers aged 55 to 80 will take different doses of GGC daily for three months. Res…

This study tests whether combining mindfulness meditation with dual-task training (like walking while doing mental math) can improve thinking and physical skills in people with mild cognitive impairment after a stroke. Sixty participants will be randomly assigned to the combined …

This study tests whether combining a non-invasive brain stimulation technique called accelerated iTBS with computerized cognitive training can help people with mild cognitive impairment (MCI). Fifty adults aged 60-85 will receive the brain stimulation and be randomly assigned to …

This 26-week study tests whether taking creatine daily and doing resistance training (weightlifting) can improve thinking, memory, and physical function in older adults with mild cognitive impairment. Two hundred participants aged 60+ will be randomly assigned to creatine or plac…

This study tests whether automated, personalized text messages can reduce mood and behavior symptoms in people with mild cognitive impairment (MCI). Researchers will enroll 160 adults aged 50 and older with early memory issues and mild behavioral symptoms. Participants receive da…

This study tests whether a home-based digital cognitive-training program called RICORDO can help people aged 50 and older with mild cognitive impairment or subjective cognitive decline better manage their own health. Participants will be randomly assigned to use RICORDO on a tabl…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with cognitive training, can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in…

This study tests a gentle, non-invasive brain stimulation technique called tACS to see if it can improve working memory in people with mild cognitive impairment (MCI). Twenty volunteers aged 60 and older will receive daily stimulation sessions for two weeks. The main goal is to s…

This study tests a group cognitive rehabilitation program for 40 people with mild cognitive impairment (MCI), a condition that raises dementia risk. The program combines brain exercises and lifestyle advice over 12 weeks. Researchers want to see if it improves thinking, behavior,…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study tests whether using a music-based rhythm training app or a word search app for up to 8 weeks can improve working memory and focus in older adults. Participants, including those with mild cognitive impairment, will complete cognitive tests before, after, and 6 months la…

This study tests a workshop series designed for people aged 60 and older with early-stage memory loss who live alone. The program provides education and skills training via Zoom to reduce stress, improve well-being, and help with future planning. Researchers will gather feedback …

This study tests a digital cognitive rehabilitation system called RICORDO for people with mild memory complaints, mild cognitive impairment, or early Alzheimer's dementia. About 102 participants will use the digital program or standard paper-and-pencil exercises at home for 5 wee…

This study tests whether a 24-week online positive psychology program can improve thinking skills and brain function in older adults with very early memory decline (subjective cognitive decline or mild cognitive impairment). About 128 participants will be randomly assigned to the…

This study tests whether doing crossword puzzles can help people with mild cognitive impairment (MCI) keep their thinking skills sharp. Researchers will compare doing 4 puzzles per week, 1 puzzle per week, or health education. The goal is to see if puzzles can slow memory decline…

This study tests if a fast form of brain stimulation (accelerated dTMS) combined with memory exercises can improve thinking skills in older adults with mild memory issues. About 30 people aged 55-85 with mild cognitive impairment or memory concerns will receive either real or fak…

This study tests a new approach to improve sleep in people aged 60+ with mild cognitive impairment (MCI). It combines a gentle brain stimulation technique called TMS with an internet-based sleep therapy program. The goal is to see if this combo can ease insomnia and possibly boos…

This study tests a computer-based memory strategy program called E-MinD Life in 60 older adults, including healthy individuals, those with memory complaints, and those with mild cognitive impairment. The program teaches memory strategies through daily activities over 9 weeks. The…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia, along with their care partners, reduce medications that may be harmful. Participants receive educational materials and can meet with a pharmacist to review their…

This study looks at whether changes in movement, like how fast you can tap your fingers, can help detect early signs of dementia. Researchers will study 200 people, some with mild cognitive impairment (MCI) and some healthy, using a special glove to measure finger movements. The …

The CROWN-I study is an observational research project involving 160 people with Alzheimer's disease or mild cognitive impairment. Participants will provide samples and undergo assessments over time to help researchers understand the molecular and genetic features that distinguis…

This observational study is recruiting 600 participants to improve detection and understanding of dementia with Lewy bodies (DLB). Researchers will collect clinical data, brain scans, and spinal fluid samples from people with early symptoms like hallucinations or movement problem…

This study is testing whether a series of online brain games (CogniFit) can improve memory, thinking skills, and emotional well-being in healthy older adults and those with mild cognitive impairment (MCI). Researchers will compare trained and untrained groups to see if any benefi…

This study is testing whether a non-invasive electrical stimulation technique can improve working memory, attention, and thinking skills in healthy older adults and those with mild cognitive impairment. The stimulation targets deep brain structures without surgery, using special …

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 participants, including people with memory concerns or dementia and their healthy family members. The goal is to better understand how gene…

This observational study is testing a new model that combines genetic data, blood tests, and digital monitoring (like sleep and activity trackers) to predict early memory decline in adults aged 55 and older who carry the ApoE4 gene variant. Researchers will follow 100 participant…

This study is following 100,000 people in China over many years to learn more about dementia and memory loss. Researchers will track who develops these conditions, look for risk factors like genes and lifestyle, and find better ways to diagnose and prevent dementia. The goal is t…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study checks if a simple online cognitive test (Creyos) can accurately track memory and thinking changes in older adults with mild cognitive impairment or past depression. About 150 participants will take both online and in-person tests over up to 5 years. The goal is to see…

This study tests whether a mild electrical pulse to the ear—called transcutaneous auricular vagus nerve stimulation—can improve decision-making and problem-solving. Researchers will compare results in healthy adults, people with mild cognitive impairment, and those with Parkinson…

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…

This study follows 1,000 adults with primary aldosteronism—a condition where the adrenal glands make too much aldosterone—to see how it affects thinking and memory over up to 5 years. Participants will take regular cognitive tests and have medical check-ups. The goal is to learn …

This study looks at how dementia and mild cognitive impairment (MCI) affect thinking, daily activities, and mood. Researchers will assess 151 adults aged 50-86 with these conditions to better understand their challenges. The goal is to improve care by tailoring treatments to each…

This study tests a memory support program for Chinese American adults aged 55 and older with mild cognitive impairment (MCI). The program, originally designed for English speakers, will be adapted for Mandarin and Cantonese speakers. The goal is to see if the program is practical…

This observational study tests a mobile app that uses a dynamic difficulty adjustment system to personalize cognitive activities for people with mild cognitive impairment or mild Alzheimer's disease, as well as healthy older adults. The goal is to see if the app can reach a stabl…