MILD COGNITIVE IMPAIRMENT (MCI)

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Researchers think these drugs might slow memory decline by blocking a process linked to Alzheimer's. Abo…

This study follows 120 people with early Alzheimer's or mild cognitive impairment who are taking lecanemab, a new FDA-approved drug that targets amyloid plaques in the brain. Researchers will track changes in thinking, daily function, and brain scans over 18 months, while also wa…

This early study is testing a combination of two drugs, parthenolide and ipriflavone (called NPC-1), in 40 adults aged 55 and older who have early Alzheimer's or memory concerns. The goal is to see if the treatment is safe and can improve blood markers linked to Alzheimer's brain…

This study tests a digital cognitive rehabilitation system called RICORDO for people with mild memory complaints, mild cognitive impairment, or early Alzheimer's dementia. The goal is to see if using this computer program at home improves thinking skills and helps people better m…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with cognitive training can improve memory, thinking, and mood in people with mild cognitive impairment or early-stage dementia. Fifty participants will receive both real and placebo stimulation in …

This study tests whether a 24-week online positive psychology program can improve memory, thinking, and well-being in older adults with very early signs of dementia. About 128 people with subjective cognitive decline or mild cognitive impairment will join. Half take the program (…

This study tests a new way to improve sleep in people with mild cognitive impairment (MCI). It combines gentle brain stimulation (transcranial magnetic stimulation) with talk therapy (cognitive behavioral therapy for insomnia). The goal is to see if this approach can help with sl…

This study tests a group program for people with mild cognitive impairment (MCI) — a condition that raises the risk of dementia. The program combines brain exercises and lifestyle advice, using a web app, over 12 weeks. Researchers want to see if it improves memory, thinking, and…

This study tests whether a digital intervention can improve working memory and inhibitory control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home training, with a fol…

This study tests a safe, painless brain stimulation method called tACS to see if it can improve working memory in older adults with mild cognitive impairment (MCI). Twenty participants aged 60+ will receive daily 1-hour sessions for two weeks. The goal is to see if the treatment …

This study tests a mobile app called SuperBrain BOOM that gives personalized physical activities to older adults (ages 50-85) with mild cognitive impairment. Over 12 weeks, participants use a tablet or smartphone to follow the program, while researchers check if it safely improve…

This study tests whether doing crossword puzzles can help people with mild cognitive impairment (MCI) keep their thinking skills sharp. Researchers will compare doing 4 puzzles per week, 1 puzzle per week, or receiving health education. The goal is to see if puzzles can slow memo…

This study tests whether a fast form of brain stimulation (accelerated deep TMS) combined with memory exercises can safely improve thinking skills in older adults with mild memory issues. About 30 participants aged 55-85 with subjective memory decline or mild cognitive impairment…

This study tests whether a digital program called RICORDO can help people aged 50+ with mild memory problems better manage their own health and daily life. Participants will use RICORDO or a standard education program at home for five weeks. Researchers will compare changes in he…

This study tests a simple, non-invasive device that plays soft sounds during sleep to boost deep sleep and improve memory. Sixty older adults with mild memory problems will use the device at home for four weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests a Zoom-based education and skill-training program for people aged 60+ with early-stage dementia or mild cognitive impairment who live alone. The goal is to reduce stress, improve well-being, and help plan for the future. Researchers will gather feedback from 70 p…

This study tests a personalized therapy delivered by text or voice messages on a smartphone to help people with mild cognitive impairment manage mood and behavior issues. Researchers will enroll 160 adults aged 50 and older who have early memory problems but not dementia. The goa…

This study tests whether combining a gentle, non-invasive brain stimulation technique (called iTBS) with computer-based thinking exercises can help people with mild cognitive impairment (MCI). About 50 adults aged 60-85 will receive the same brain stimulation but be randomly assi…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study tests a computer program designed to help older adults improve their memory for everyday tasks. It includes healthy seniors, those with memory complaints, and people with mild cognitive impairment. The program uses memory strategies based on daily activities. The goal …

This study tests if a gentle electrical pulse on the ear can improve decision-making and problem-solving. Researchers will include healthy adults, people with mild cognitive impairment, and those with Parkinson's disease. The goal is to see if this safe, non-invasive method can b…

This study checks if a website called Creyos can accurately measure thinking skills in older adults who have mild memory problems or a history of depression. About 150 participants will take online tests every three months and in-person tests once a year for up to five years. The…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia and their caregivers learn about and reduce potentially harmful medications. A pharmacist will work with them to align medicines with their personal goals. The st…

This observational study in Seoul, Korea, looks at how everyday emotional stress impacts memory and thinking in adults aged 60 and older. Over 180 participants will use a smartphone app and a smartwatch to report their feelings and do quick brain games several times a day for two…

This study looks at whether a combination of genetic tests, blood markers, and data from wearable devices can predict early memory problems in people aged 55 and older who carry the ApoE4 gene, which raises Alzheimer's risk. Researchers will follow 100 participants for two years …

This observational study will follow 50,000 people with Alzheimer's or related dementias for many years. Researchers will collect medical information during routine doctor visits to learn how the disease progresses and how treatments work in real life. The goal is to improve unde…

This study is following 100,000 people aged 55 and older in China to learn more about dementia, including Alzheimer's disease. Researchers will track who develops memory problems, look for genetic and lifestyle risk factors, and find better ways to diagnose the disease. The goal …

This study looks at how dementia and mild cognitive impairment (MCI) impact thinking, daily activities, and mood. Researchers will assess 151 adults aged 50-86 to better understand these conditions. The goal is to improve care by tailoring treatments to each person's needs.

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 people with memory concerns or early-onset dementia, plus their family members. The goal is to better understand how genes influence the di…

This study tests a memory support program originally designed for English speakers, now adapted for Chinese American seniors with mild cognitive impairment (MCI). About 60 participants who speak Mandarin or Cantonese will either receive trainer-led training or self-study material…

This study follows 1000 adults with primary aldosteronism (a hormone condition that raises blood pressure) for up to 5 years to see how often thinking and memory problems develop. Participants take regular cognitive tests and medical check-ups. The goal is to understand how commo…

This study tests a smartphone app that changes the difficulty of brain games based on each person's performance. Researchers want to see if the app works well for people with mild cognitive impairment or mild Alzheimer's and for healthy older adults. About 55 participants will us…