MILD COGNITIVE IMPAIRMENT(MCI)

This early-stage study is testing whether two HIV medications (emtricitabine and Descovy) are safe for people with mild cognitive impairment, which often leads to Alzheimer's disease. Researchers want to see if these drugs, which block a specific enzyme, might help slow memory de…

This study is testing whether a gentle, non-invasive electrical stimulation applied to the scalp can improve working memory in people with mild cognitive impairment (MCI), a condition that often precedes Alzheimer's disease. Researchers will enroll 20 participants aged 60+ with M…

This study is testing whether regularly doing crossword puzzles can help slow down memory and thinking problems in older adults with mild cognitive impairment (MCI), a condition that often leads to dementia. Researchers will compare doing four puzzles a week to one puzzle a week,…

This study is testing whether a personalized digital brain training program, used at home on a tablet, can help older adults with mild memory problems become more confident and active in managing their own health and daily life. Researchers will compare this program to a standard…

This study is testing a new digital brain training program called RICORDO to see if it can help older adults with early memory problems. It will compare the digital program to standard paper-and-pencil exercises to see which is better at improving overall thinking skills and help…

This study is testing whether a personalized exercise program delivered through a smartphone or tablet app, called SuperBrain BOOM, can help improve thinking skills, mood, and physical ability in older adults (ages 50-85) with mild cognitive impairment (MCI). For 12 weeks, one gr…

This study aims to closely watch 120 people with early Alzheimer's disease who are taking the drug lecanemab. Researchers will track changes in their brain scans, memory, thinking, and daily life over 18 months to see how well the drug works and monitor for any side effects. The …

This study is testing whether a free, online group program focused on building positive emotions and strengths can help improve memory and brain function in older adults who are noticing early signs of cognitive decline. About 128 participants with either subjective memory compla…

This study is testing a new computer program designed to help older adults manage memory changes. The program teaches strategies to remember things needed for everyday tasks, like shopping or managing medications. Researchers want to see if using this program is helpful and pract…

This study is testing whether combining two treatments can improve sleep for people aged 60+ who have both insomnia and mild memory problems. One treatment is a safe, gentle form of brain stimulation (TMS), and the other is a type of talk therapy for insomnia (CBT-I). Researchers…

This study is testing whether a non-invasive brain stimulation technique, combined with online memory training, can improve thinking skills in older adults with mild memory concerns. Researchers will compare a real stimulation treatment to a fake one to see if it's safe and if it…

This study is testing whether automated, personalized text messages can help people with mild cognitive impairment manage their mood and behavior symptoms. The messages deliver Acceptance and Commitment Therapy, a type of psychological support, and are sent based on each particip…

This study is testing whether a gentle electrical stimulation applied to the ear can improve thinking skills like decision-making and problem-solving. Researchers are enrolling 80 healthy adults and people with Parkinson's disease to try this non-invasive stimulation during brain…

This study is testing whether a proven memory support system can be helpful for older Chinese Americans who have mild thinking and memory problems. Researchers are adapting the program for Mandarin and Cantonese speakers to see if it improves daily life and memory skills. The stu…

This study is testing whether using a brain-training app on a tablet for 8 weeks can help improve memory and focus in older adults, including those experiencing mild memory problems. Researchers will compare two different training apps to see if they help. Participants will do al…

This is a large, long-term observational study aiming to understand dementia and cognitive decline in China. It will follow up to 100,000 people, including those with normal cognition, mild impairment, and different types of dementia, over many years. The main goal is to collect …

This study aims to test whether an online brain assessment platform called Creyos works well for older adults with mild memory concerns or past depression. Researchers want to see if this online tool can track changes in thinking skills as accurately as traditional paper-and-penc…

This study aims to better understand how dementia and mild cognitive impairment (MCI) affect a person's ability to think, perform daily tasks, and manage their mood. Researchers will look back at the medical records of 151 patients to see how these conditions progress over time. …

This study is testing a smartphone app designed to measure thinking skills in older adults. It aims to see if the app's adaptive difficulty system works similarly for people with mild memory problems and healthy individuals. Researchers want to learn if the app can reliably detec…

This study aims to understand how different types of dementia develop and progress over time. Researchers are following over 1,500 people aged 50-90, including those with various dementia types and healthy individuals, across Canada. Participants undergo regular brain scans, memo…

This study aims to understand if people with a hormone disorder called primary aldosteronism are more likely to develop memory problems or dementia. Researchers will follow 1,000 patients for up to 5 years, giving them regular memory tests and health check-ups. The goal is to lea…