MILD COGNITIVE IMPAIRMENT (MCI)

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow disease progression by blocking a process linked to Alzheimer's. A…

This study tests whether a drug made from Ginkgo Biloba extract (Egb761) can lower a key Alzheimer's protein in the blood and improve thinking skills. Fifty adults with mild memory problems will take the drug twice daily for 6 months. The goal is to see if it can reduce brain dis…

This study is developing a web-based app that analyzes how you speak and remember things to quickly detect early cognitive problems like dementia or Alzheimer's. Researchers will enroll 500 people (healthy adults over 45 and those already diagnosed with mild cognitive impairment …

This trial tests a program that pairs oral motor exercises (like tongue and lip strengthening) with cognitive tasks (like memory or attention games) in adults aged 50 and older who have oral frailty and mild thinking problems. The goal is to see if doing both at the same time can…

This study tests whether low-intensity focused ultrasound (LIFU) is safe and tolerable for people with mild cognitive impairment (MCI), a condition that can lead to dementia. Participants receive either real or sham ultrasound to the brain. Researchers monitor side effects and me…

This study tests whether a tablet-based exercise program called SuperBrain BOOM can improve thinking, memory, and physical function in older adults with mild cognitive impairment (MCI). Forty-five participants aged 50-85 will use the program at home or in a clinic for 12 weeks, w…

This study tests whether a non-invasive brain stimulation technique called transcranial temporal interferential stimulation (tTIS) can improve thinking, memory, and the ability to walk while doing another task in older adults with mild cognitive impairment. Forty participants age…

This study tests whether a 12-month program combining telehealth sessions with daily AI-guided brain exercises can help older adults with mild cognitive impairment (MCI) maintain or improve their memory and thinking skills. 130 participants will be randomly assigned to either the…

This study tests whether teaching older adults with early-stage dementia how to use aromatherapy through augmented reality (AR) can improve their mood and behavior. 300 participants in Taiwan will either receive AR-based aromatherapy education or standard activities. The goal is …

This pilot study tests whether automated instant messages can help manage neuropsychiatric symptoms like depression and anxiety in people with mild cognitive impairment (MCI). Forty adults aged 50 and older with MCI will receive an 8-week program of guided messages based on accep…

This study looks at whether taking a daily powder made from fermented garlic and lettuce for two months can help improve memory and thinking in adults with mild cognitive impairment (MCI). About 60 adults with MCI will take the powder or a placebo. Researchers will measure change…

This study uses PET imaging to measure two key proteins in the brain—amyloid and tau—that are hallmarks of Alzheimer's disease. Researchers will follow 120 participants over five years, including people with normal aging, mild cognitive impairment, and dementia, to see how these …

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study is testing whether simple blood tests can accurately diagnose dementia in everyday clinic settings. Over 3,000 people aged 45 and older with memory problems will give blood samples and answer questionnaires. Researchers will check how reliable and acceptable these bloo…