MILD COGNITIVE IMPAIRMENT (MCI)

This study tests an experimental pill called RP902 in 360 people with mild cognitive impairment caused by Alzheimer's disease. Participants will take the drug or a placebo for 48 weeks to see if it slows memory decline. The trial is conducted at about 50 sites in China and may ex…

This Phase 1 trial tests a single injection of QLH2405 in 68 healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The main goal is to check safety and how the body processes the drug. It is too early to know if QLH2405 will help treat Alzheimer's.

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This study tests whether a natural compound from soy, called genistein, can slow down memory and thinking problems in people with mild cognitive impairment (MCI), often an early sign of Alzheimer's disease. About 150 adults over 50 with MCI will take either genistein or a placebo…

This study tests a home-based dual-task training program for people with Parkinson's disease who have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while playing brain-training games on a tablet, three times a week for 3…

This study will test the antibody drug lecanemab in 120 people with mild cognitive impairment or mild-to-moderate Alzheimer's disease. Using PET scans to measure amyloid and tau proteins in the brain, researchers hope to identify which patients are most likely to benefit from tre…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

This study will check if a blood test can find signs of Alzheimer's disease in people with early memory concerns. Researchers will test 1,000 adults aged 55 and older in primary care. The goal is to see if blood markers for amyloid and tau proteins match those found in spinal flu…

This study will check if a Greek version of the Montreal Cognitive Assessment (MoCA) test is reliable for spotting early memory problems. Researchers will enroll 250 Greek-speaking adults aged 55-85, including some with mild cognitive impairment or dementia. The goal is to give d…

This study tests whether a year-long virtual lifestyle coaching program—focusing on diet, sleep, and activity—can lower Alzheimer's-related blood markers in 1,200 adults aged 60-80 who carry a genetic risk. Participants wear an Oura ring for tracking and provide blood samples. Th…

This pilot study tests whether a personalized lifestyle program combining workshops, remote coaching, and a smartphone app can help adults aged 55-75 at risk for dementia adopt healthier habits. 300 participants will either receive tailored guidance or standard advice. The main g…

This study tests whether a simple home exercise program can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4-5). 124 participants will either do low-intensity walking and strength exercises or receive standard care. …

This study will test whether a single 30-minute session of Baduanjin (a gentle qigong exercise) or elastic band exercises can improve visuospatial working memory in 60 elderly people with mild cognitive impairment. Participants will perform one exercise session, and their memory …

This pilot study tests whether simple bedroom changes and sleep tips can improve sleep for older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to adjust the bedroom environment and provide s…

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests whether a daily supplement made from cat's claw bark and oolong tea can help improve memory and thinking in adults aged 40-85 with mild cognitive impairment. About 154 participants will take either the supplement or a placebo for 6 months. They will complete digi…

This study tests whether older adults with mild cognitive impairment can complete a 4-month virtual reality maze training program. Participants will wear VR goggles and navigate through 50 different mazes while their brain activity is recorded with EEG. The goal is to see if this…

This study looks at how different types of exercise—cycling or strength training—affect brain function and physical frailty in older adults with mild cognitive impairment (MCI), an early stage of memory loss. About 36 people aged 60 to 85 with MCI will be randomly assigned to 12 …

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests a 14-week program that combines mentally stimulating activities with healthy lifestyle education to improve cognitive abilities in older adults with mild cognitive impairment (MCI). Two hundred participants aged 60 and older will be randomly assigned to one of fo…

This study compares two types of cognitive training in adults aged 65 and older with mild cognitive impairment (MCI). One group will do 'dual-task training' that combines physical movement with mental tasks, like walking while counting backward. The other group will use computer-…

This study tests whether sensory integration training—exercises that stimulate balance, body awareness, and touch—can improve thinking, quality of life, and social participation in older adults with mild cognitive impairment. Forty participants aged 65–85 will be assigned to eith…

This study tests whether adding stress reduction techniques to cognitive stimulation therapy can improve thinking skills in adults with mild cognitive impairment. Twelve Pakistani adults aged 45 and older with mild memory problems and moderate to high stress will take part. The c…

This pilot study will test whether a specially designed mindfulness program, called Mindful Awareness Practice (MAP), can reduce stress and improve memory, mood, and well-being in older adults (65+) with mild cognitive impairment and high stress. Thirty participants will be rando…

This study tests a nasal device (iNAP) that uses gentle suction to keep the airway open during sleep. It includes 65 adults aged 50-75 with mild cognitive impairment and moderate-to-severe sleep apnea. Half will use the device nightly for 24 weeks, while the other half receive sl…

This study tests whether playing interactive games with a social robot can improve thinking skills, mood, and quality of life in older adults with mild cognitive impairment or dementia. Researchers will randomly assign 80 participants to either 12 weeks of robot game sessions or …

This study tests whether a computer-based stepping game, called Smart±step, can help older adults with mild cognitive impairment (MCI) improve their balance, thinking, and quality of life while reducing their risk of falling. About 70 participants will use the game, which combine…

This study explores whether tracking eye movements and arm motions during virtual reality driving tasks can help identify early signs of mild cognitive impairment (MCI) in older adults. Researchers will enroll 192 participants, including healthy young adults, healthy older adults…

This study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…

This study explores whether combining a brain-computer interface with mild electrical stimulation or mindfulness can strengthen attention and memory in healthy adults and those with mild cognitive impairment. Participants will perform memory tasks while their brain activity is mo…

This study looks at 150 older adults with mild cognitive impairment who already practice Tai Chi regularly. Researchers want to see if a computer model can predict who gets the most cognitive benefit and what dose works best. It's an observational study, meaning no one is assigne…

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…

This study will test whether advanced MRI scans and blood tests can predict how well Alzheimer's patients respond to antibody drugs like lecanemab and donanemab. Researchers aim to create personalized models that show when amyloid plaques have been cleared from the brain, potenti…

This study aims to understand how walking patterns, body composition, and a blood protein called BDNF differ between older adults with mild cognitive impairment and healthy older adults. Researchers will measure gait, handgrip strength, and cognitive function in 60 participants a…

This study looks at how mental health issues, like depression or anxiety, affect people with mild cognitive impairment (MCI). Researchers will study 118 adults aged 50-72 to see how these issues impact their awareness of memory problems, social life, and work. The goal is to bett…

This study will follow 300 older adults (70+) who have mild cognitive impairment (MCI) for one year to see if feeling lonely makes them more likely to develop dementia. Researchers will track who progresses from MCI to dementia and compare loneliness levels. The goal is to unders…