MILD COGNITIVE IMPAIRMENT(MCI)

This study aims to find better ways to catch early signs of memory loss in community settings and test if new treatments can slow it down. It will involve 600 adults aged 55 and older in the U.S. who have mild cognitive impairment. Researchers will compare standard care against w…

This study is testing an online program called e-ALIGN. It aims to help older adults with mild memory problems or dementia, and their caregivers, work with doctors to safely stop or reduce medications that might be harmful or unnecessary. The program sends educational videos and …

This study will test whether a natural compound called genistein, found in soy, can slow down memory and thinking problems in people with early Alzheimer's disease. About 150 participants with mild cognitive impairment will take either the genistein extract or a placebo daily for…

This study aims to see if a combination of mindfulness meditation and gentle, non-invasive brain stimulation can help strengthen the brain's attention and memory networks. Researchers will work with 100 participants, including healthy older adults and those diagnosed with mild co…

This study is testing if a computer-based stepping game can help older adults with mild memory problems. The game combines mental and physical tasks, aiming to reduce their high risk of falls and improve their thinking, balance, and quality of life. Researchers will enroll 70 par…

This study is testing a home-based training program designed to help people with Parkinson's disease who are at high risk for dementia. Participants will pedal a stationary bike while playing brain-training games on a tablet, aiming to improve both thinking skills and the ability…

This study is testing whether the antibody drug lecanemab helps control Alzheimer's disease progression better than standard treatments. Researchers will follow 120 patients with early Alzheimer's or mild cognitive impairment to see who benefits most from continued treatment. Usi…

This study is testing whether a home-based exercise program can help slow down memory and thinking problems in people with advanced kidney disease. About 124 patients will either follow a 6-month program of walking and strength training or receive their usual care. The goal is to…

This early-stage study aims to see if a pill called NPC-1 (containing parthenolide and ipriflavone) is safe and can change certain markers of Alzheimer's disease in the blood over six months. It will involve 40 adults aged 55+ who have early memory concerns or mild Alzheimer's an…

This is the first human study of an experimental drug called QLH2405 for Alzheimer's disease. Researchers will test single injections in 68 healthy volunteers and people with early Alzheimer's or mild memory problems to check safety and how the body processes the drug. The study …

This study is testing whether a nightly nasal device, which uses gentle suction to keep the airway open, can help improve memory and thinking in people with early memory loss who also have moderate-to-severe sleep apnea. About 65 participants will be randomly assigned to either u…

This study is testing a new virtual reality (VR) training program designed to help older adults with mild memory concerns. Participants will wear VR goggles and practice navigating through different mazes while researchers measure their brain activity. The goal is to see if this …

This study aims to see if adding a culturally tailored stress reduction program to standard memory exercises provides extra benefit for Pakistani adults with mild cognitive impairment (early memory problems). It will compare three groups: the combined therapy, memory exercises al…

This study aims to determine if a simple blood test can help doctors diagnose Alzheimer's disease at an early stage during routine primary care visits. Researchers will enroll 1,000 adults aged 55 and older who have concerns about their memory or thinking abilities. The study wil…

This study aims to test a Greek version of a common memory and thinking test called the MoCA. Researchers will give the test to about 250 people, including healthy adults and those with memory problems, to see if it works reliably in Greek. The goal is to provide doctors with a b…

This study tests whether a personalized digital lifestyle program can help prevent cognitive decline in older adults at risk for dementia. 300 participants aged 55-75 will use a smartphone app and smartwatch while receiving coaching on diet, exercise, sleep, and other lifestyle f…

This study is testing if a supervised ketogenic diet (a very low-carb, high-fat eating plan) can help reduce pain and improve thinking in older adults who have both osteoarthritis and mild memory problems. Ten participants will follow the diet, and researchers will check their pa…

This study is testing whether making simple changes to a person's bedroom and giving brief sleep tips can improve sleep for older adults. It focuses on people aged 65+ who live alone, have memory concerns, and have trouble sleeping. Researchers will visit participants' homes to h…

This study is testing if a shorter, 5-week virtual brain training program is just as good as the standard 8-week program for older adults with mild cognitive impairment (MCI). Researchers want to see if the shorter version can still help improve memory, thinking, daily life, and …

This study is testing whether playing interactive games with a social robot can help older adults with mild memory problems or dementia. About 80 participants will either play these robot games twice a week for 12 weeks or receive their usual care. Researchers will use questionna…

This study aims to see if a special training program that combines different senses can help older adults with mild cognitive impairment. It will involve 40 participants and measure if the training improves their memory, quality of life, and social engagement. The goal is to find…

This study is testing whether a 12-week mindfulness program can help reduce stress and improve memory, mood, and well-being in older adults with mild cognitive impairment. Researchers will compare the mindfulness program to a general health education program. The goal is to see i…

This study aims to understand how mental health conditions like anxiety or depression affect people diagnosed with mild cognitive impairment (MCI), which involves early memory or thinking problems. Researchers will observe 118 participants aged 50-72 to see how these mental healt…

This study aims to understand if differences in how people walk, their physical strength, and a specific brain health marker in the blood can help identify early signs of dementia. Researchers will compare 60 older adults with mild memory concerns to healthy older adults during a…

This international registry aims to track 50,000 people with Alzheimer's disease and related conditions over many years. By collecting real-world information from routine doctor visits across different countries, researchers hope to better understand how the disease progresses an…

This study aims to develop better ways to monitor Alzheimer's treatment using MRI scans instead of current PET scans. Researchers will follow 50 people with early Alzheimer's who are receiving standard antibody treatments to see if MRI can predict when treatment has worked enough…

This study aims to find out if feeling lonely increases the risk of developing dementia in older adults who already have mild memory problems. Researchers will follow 300 participants aged 70 and older for one year to see who progresses from mild cognitive impairment to dementia.…

This study is testing whether a simple walking monitor can help track early signs of memory problems in older adults. Researchers will have 150 participants wear special insoles and ankle devices to measure their walking patterns both in a lab and at home for one week. The goal i…