Creatine and lifting weights: a new hope for aging brains?

NCT ID NCT06948149

Recruiting now Symptom relief Sponsor: Western University, Canada Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This 26-week study tests whether taking creatine daily and doing resistance training (weightlifting) can improve thinking, memory, and physical function in older adults with mild cognitive impairment. Two hundred participants aged 60+ will be randomly assigned to creatine or placebo, combined with either weightlifting or balance/stretching classes. Researchers will measure changes in working memory, reaction time, and other cognitive skills before and after the program.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: creatine monohydrate
What this could lead to: If it works, this could point toward a simple, low-cost way to slow cognitive decline and improve physical function in older adults with mild memory problems.
What could go wrong: This is an early-stage trial with 200 participants, so results may not apply to everyone. The benefits of creatine for brain health are still unproven, and the study relies on cognitive tests that may not capture real-world improvements.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CREATINE EXERCISE MILD COGNITIVE IMPAIRMENT (MCI)

Contacts and locations

Locations

Western University
RECRUITING

London, Ontario, N6E 1Z6, Canada

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