New adaptive radiation boosts rectal cancer response rates
NCT ID NCT07580027
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a personalized radiation approach for locally advanced rectal cancer. By adjusting the radiation dose halfway through treatment based on a special MRI scan, doctors hope to increase the number of patients whose tumors completely disappear before surgery. The trial will enroll 33 people to see if this method can raise the complete response rate from 41% to 70%.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy (adaptive radiotherapy) and chemotherapy
What this could lead to
If successful, this approach could significantly increase the chance of eliminating the tumor before surgery, potentially reducing the need for more aggressive treatments.
What could go wrong
This is a small, early-phase study (33 participants) and the results may not apply to all patients. The treatment involves radiation and chemotherapy, which carry risks like fatigue, bowel issues, and skin reactions.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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I.R.C.C.S. San Raffaele Hospital
Milan, 20132, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••