A new radiation combo may spare the rectum in early cancer

NCT ID NCT06501053

Recruiting now Disease control Sponsor: Alexander Valdman Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether a combination of contact X-ray brachytherapy and short-course radiotherapy can preserve the rectum in people with early-stage rectal cancer. Participants receive this experimental radiation regimen, with some also getting chemotherapy. The goal is to see if this approach is as good as standard treatment at avoiding rectal removal while keeping the cancer under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Contact X-ray brachytherapy combined with short-course radiotherapy, with or without capecitabine chemotherapy
What this could lead to: If successful, this approach could offer a non-surgical option to treat early rectal cancer while preserving the rectum, avoiding the need for removal.
What could go wrong: This is a phase II trial, so results are preliminary. The treatment may not be as effective as standard care, and there are risks of toxicity and potential failure requiring surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RECTAL ADENOCARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Locations

Karolinska University Hospital, Theme Cancer, Dept of Pelvic cancer
RECRUITING

Stockholm, Solna, 171 76, Sweden
Uppsala University Hospital, Colorectal Surgery
RECRUITING

Uppsala, 751 85, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.