Blood test could replace CT scans for head injuries

NCT ID NCT07036146

Recruiting now Diagnosis Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is testing whether a blood test for a protein called S100B can help doctors quickly rule out brain injury in people who come to the emergency room with a head injury. The test is already known to be very accurate at predicting when no brain injury is present. If it works well, it could reduce the need for CT scans and shorten ER visits. The study will include 1,000 patients of all ages, including pregnant women.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could provide a quick blood test to rule out brain injury after head trauma, reducing unnecessary CT scans and emergency room visits.
What could go wrong: This is an observational study, not a treatment trial. The test is already known to be highly sensitive, but it may not change clinical practice or be adopted widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Craniocerebral Trauma head injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD TRAUMA

Contacts and locations

Locations

IRCCS Ospedale San Raffaele
RECRUITING

Milan, Milano, 20132, Italy

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