New insulin timing trick may tame blood sugar after pizza and burgers

NCT ID NCT05454891

Completed Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving insulin as an extended bolus (over time) instead of all at once helps control blood sugar after high-fat, high-protein meals in teens with type 1 diabetes. Thirty teens using a closed-loop insulin pump ate a standardized breakfast and received either an extended or standard bolus on different mornings. The goal was to see if the extended bolus reduces prolonged high blood sugar or early low blood sugar.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: insulin (extended bolus via Tandem t:slim X2 insulin pump)
What this could lead to: If it works, this could give people with type 1 diabetes a better way to manage blood sugar after rich meals, reducing highs and lows.
What could go wrong: This is a small, early study in 30 teens, so results may not apply to everyone. The benefit may be small or not work for all meal types.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES

Contacts and locations

Locations

University of California San Francisco

San Francisco, California, 94158, United States

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