New hope for diabetics with kidney transplants: islet cells may end insulin shots

NCT ID NCT01123187

Completed Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Fourteen participants received up to three infusions of donor islet cells along with steroid-free immunosuppression. The goal was to see if they could stop taking insulin and keep their blood sugar under control one year later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: islet cell transplant
What this could lead to: If successful, this approach could help some people with type 1 diabetes who have had a kidney transplant achieve insulin independence and better blood sugar control.
What could go wrong: This is a small, early-phase study with only 14 participants, so results may not apply to everyone. The procedure and required immunosuppression carry risks like infection and bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypoglycemia type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNOSUPPRESSION ORGAN TRANSPLANTATION TYPE 1 DIABETES

Contacts and locations

Locations

University Hospital of Lille

Lille, Nord, 59000, France

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