Could a gut hormone and amino acid combo prevent low blood sugar in diabetes?

NCT ID NCT06881472

Completed Knowledge-focused Sponsor: Asger Lund, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how two substances—GIP, a natural gut hormone, and alanine, an amino acid from protein—work together to release glucagon, a hormone that raises blood sugar. Researchers tested 10 people with and without type 1 diabetes to see if combining GIP and alanine boosts glucagon more than either alone. The goal is to understand how this might protect against low blood sugar in type 1 diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Glucose-dependent Insulinotropic Polypeptide (GIP) and alanine
What this could lead to: If successful, this research could point toward new ways to help people with type 1 diabetes avoid dangerously low blood sugar by boosting glucagon release.
What could go wrong: This is a very small, early-stage study with only 10 participants, so results may not apply broadly. It is designed to gather knowledge, not to test a treatment.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES

Contacts and locations

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Locations

Gentofte Hospital

Hellerup, 2900, Denmark

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