Could a modified starch help tame type 1 diabetes?

NCT ID NCT06057454

Completed Disease control Sponsor: Rise Therapeutics LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested the safety of a new drug called R-5280, a modified starch, in 9 children aged 11-17 who were recently diagnosed with type 1 diabetes. The study compared R-5280 to a placebo (food-grade starch) and monitored side effects and blood sugar levels over 12 weeks. The goal was to see if the drug is safe and tolerable, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: R-5280 (a modified starch)
What this could lead to: If it works, this could point toward a way to help manage type 1 diabetes by affecting gut health.
What could go wrong: This was a very small, early-phase safety study with only 9 participants, so it cannot prove effectiveness. The results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus type 1 diabetes mellitus 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 1 TYPE 1 DIABETES TYPE 1 DIABETES (JUVENILE ONSET)

Contacts and locations

Locations

Edward Jenner Research Group LLC

Plantation, Florida, 33317, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
UTSW Medical Center

Dallas, Texas, 75390, United States

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