Could a weekly shot help people with type 1 diabetes lose weight and control blood sugar?
NCT ID NCT05537233
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested a weekly injection of semaglutide (a drug used for type 2 diabetes and weight loss) in 115 adults with type 1 diabetes and obesity who already use an automated insulin pump. The goal was to see if adding semaglutide helps improve blood sugar levels, reduce hypoglycemia, and lower body weight. Participants received either semaglutide or a placebo for 26 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
semaglutide
What this could lead to
If successful, this could offer a new way to improve blood sugar control and reduce weight in people with type 1 diabetes who are overweight.
What could go wrong
This is a small, early-phase trial (Phase 2) with only 115 participants. Results may not apply to everyone, and semaglutide can cause side effects like nausea or vomiting.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Barbara Davis Center for Diabetes
Aurora, Colorado, 80045, United States
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Harold Schnitzer Diabetes Health Center
Portland, Oregon, 97239, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Iowa Diabetes Research Center
West Des Moines, Iowa, 50265, United States