New drug cocktail aims to tame type 1 diabetes

NCT ID NCT05696366

Ongoing Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a combination of two drugs, sotagliflozin and volagidemab, can improve blood sugar control in adults with type 1 diabetes. The 24 participants will receive both drugs or a placebo in a crossover design. The goal is to see if this approach can help manage the disease more effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sotagliflozin and volagidemab
What this could lead to: If successful, this combination could offer a new way to help people with type 1 diabetes better manage their blood sugar and reduce diabetes-related complications.
What could go wrong: This is a small, early-phase trial (Phase 1/2) with only 24 people. The drugs may not work as hoped or could cause side effects. Results may not apply to everyone with type 1 diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES

Contacts and locations

Locations

UC San Diego Altman Clinical & Translational Research Institute

La Jolla, California, 92037, United States

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