New study probes why kidney disease still strikes in type 1 diabetes

NCT ID NCT05319990

Ongoing Knowledge-focused Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why up to 40% of people with type 1 diabetes develop kidney disease, even with better blood sugar control. Researchers will use kidney biopsies and advanced imaging in 100 adults to find hidden risk factors like insulin resistance and inflammation. The goal is to uncover new ways to prevent or treat diabetic kidney disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal new targets for preventing or treating diabetic kidney disease in type 1 diabetes.
What could go wrong: This is an observational study, not a treatment trial. It may not directly lead to new therapies, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Diabetes Complications diabetic kidney disease type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DIABETES DIABETES COMPLICATIONS DIABETIC KIDNEY DISEASE DIABETIC NEPHROPATHIES TYPE 1 DIABETES

Contacts and locations

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Locations

Children's Hospital Colorado

Aurora, Colorado, 80045, United States

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