Can a TB vaccine tame type 1 diabetes in kids?
NCT ID NCT05866536
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether giving the BCG vaccine (normally used for tuberculosis) twice, four weeks apart, can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were recently diagnosed with type 1 diabetes. The trial involves 100 participants and measures changes in HbA1c, C-peptide levels, and insulin use over time. It is a phase 2 study, meaning it is still early and the main goal is to see if the approach is promising and safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BCG vaccine (Bacillus Calmette-Guérin)
- What this could lead to
- If it works, this could point toward a way to help children with type 1 diabetes manage their blood sugar better and use less insulin.
- What could go wrong
- This is a small, early-phase trial with only 100 children, so results may not apply to everyone. The BCG vaccine is generally safe but can cause local reactions or rarely more serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Immunobiology Labs CNY 149
Charlestown, Massachusetts, 02129, United States
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