Can a simple pill save Insulin-Making cells in type 1 diabetes?
NCT ID NCT05594563
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether the drug DFMO can protect the body's remaining insulin-producing cells in people recently diagnosed with type 1 diabetes. About 81 participants will take either DFMO or a placebo twice daily for six months. Researchers will measure insulin production and check for side effects over a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Difluoromethylornithine (DFMO)
What this could lead to
If it works, this could point toward a way to help people with new-onset type 1 diabetes keep making some of their own insulin for longer.
What could go wrong
This is a small, early-phase trial with only 81 people. The drug may not work better than placebo, and side effects like hearing changes are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Barbara Davis Center
Aurora, Colorado, 80045, United States
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Children's Mercy Hospital
Kansas City, Kansas, 64108, United States
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IU Health Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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MHealth Fairview Masonic Children's Hospital and Specialty Clinics
Minneapolis, Minnesota, 55454, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States