Could an allergy drug protect kidneys in type 1 diabetes?

NCT ID NCT05498116

Recruiting now Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damage, and montelukast blocks certain inflammatory chemicals. The trial involves 50 adults taking either montelukast or a placebo daily for 6 months to measure changes in kidney and heart health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: montelukast
What this could lead to: If it works, montelukast could offer a new way to slow kidney disease progression in people with type 1 diabetes, potentially delaying dialysis or kidney failure.
What could go wrong: This is a small, early-phase trial with only 50 participants, so results may not apply broadly. Montelukast is generally safe but may not reduce urine protein enough to make a real difference.

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Conditions

The condition(s) this trial relates to.

Albuminuria diabetic kidney disease proteinuria type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALBUMINURIA

Contacts and locations

Locations

University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States

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