Could this Stem-Cell infusion end insulin shots for diabetics with kidney transplants?

NCT ID NCT06832410

Recruiting now Disease control Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 study tests VX-880, a stem-cell therapy infused into the liver, in 10 people with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop using insulin entirely. The therapy is given alongside standard transplant drugs to prevent rejection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VX-880 (Zimislecel), a stem-cell derived therapy infused into the liver's portal vein
What this could lead to: If successful, this could allow people with type 1 diabetes and a kidney transplant to stop taking insulin, while continuing their transplant-related immunosuppression.
What could go wrong: This is a very small early-phase 3 trial (only 10 participants). The therapy requires lifelong immunosuppression for the kidney transplant, and it may not achieve lasting insulin independence or could cause side effects.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT TYPE 1 DIABETES

Contacts and locations

Locations

King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology
RECRUITING

Riyadh, Saudi Arabia
King Faisal Specialist Hospital & Research Centre - Riyadh - Endocrinology
RECRUITING

Riyadh, Saudi Arabia
Montefiore Clinical and Translational Research Center - Endocrinology
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Perelman Center for Advanced Medicine - Endocrinology
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Toronto General Hospital - Endocrinology
RECRUITING

Toronto, Canada
UW University Hospital - Endocrinology
RECRUITING

Madison, Wisconsin, 53792, United States
Vancouver General Hospital - Gordon and Leslie Diamond Health Care Centre
RECRUITING

Vancouver, Canada

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