Can your gut bacteria change how transplant drugs work?

NCT ID NCT04953715

Ongoing Knowledge-focused Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study looks at how the natural bacteria in the body (the microbiome) interact with immunosuppressant drugs taken by kidney transplant recipients. Researchers will collect samples from the gut, mouth, nose, and urine to see if the microbiome influences how the body processes these medications. The goal is to understand why some people experience side effects like diarrhea and how drug levels vary, which could lead to better personalized treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: No intervention; observational study of microbiome and immunosuppressant metabolism
What this could lead to: Could reveal how gut bacteria influence transplant drug processing, potentially improving personalized dosing and reducing side effects.
What could go wrong: As an observational study, it cannot prove cause and effect; findings may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT KIDNEY TRANSPLANT REJECTION

Contacts and locations

Locations

HCMC

Minneapolis, Minnesota, 55415, United States
University of Minnesota

Minneapolis, Minnesota, 55414, United States

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