Your gut bacteria might predict transplant rejection

NCT ID NCT04736381

Ongoing Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study looks at whether the bacteria in your gut and blood can help predict if a kidney transplant will be rejected. Researchers will follow 70 people who are getting a kidney transplant and taking a drug called Nulojix (belatacept) as part of their usual care. They will collect stool and blood samples to look for bacterial patterns that might be linked to acute rejection during the first year after transplant. The goal is to find a simple way to identify patients at higher risk, so doctors can act sooner.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Belatacept (Nulojix) and standard immunosuppressive drugs
What this could lead to: If certain bacteria are linked to rejection, doctors might one day use a simple stool or blood test to catch rejection earlier and tailor treatments.
What could go wrong: This is a small, observational study, so it may not find a clear bacterial signature. Also, the results may not apply to all transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT REJECTION

Contacts and locations

Locations

Nephrologie hôpital Henri-Mondor

Paris, 94010 Créteil, France
Nephrologie transplantation CHRU Besançon

Besançon, 25000, France
Nephrologie transplantation CHRU Nantes

Nantes, 44200, France
Nephrologie transplantation CHRU Poitiers

Poitiers, 86021, France
Nephrologie transplantation CHRU Toulouse

Toulouse, 31059 Toulouse Cedex 9, France
Nephrologie transplantation CHRU Tours

Tours, 37044, France
Nephrologie transplantation CHU Pitié Salpetriere Paris

Paris, 75013, France
Nephrologie transplantation CHU Saint Louis Paris

Paris, 75010, France
Néphrologie, hémodialyse, aphérèses, transplantation rénale

La Tronche, 38700, France
Service de néphrologie et transplantation adulte. Hôpital Necker

Paris, 75015, France

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