Engineered immune cells aim to trick the body into accepting a new kidney
NCT ID NCT04817774
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses on safety and how well the therapy works, and involves a small group of participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TX200-TR101 (CAR-Tregs)
What this could lead to
If successful, this approach could reduce or eliminate the need for lifelong immunosuppressive drugs after kidney transplant, improving quality of life.
What could go wrong
This is an early-phase trial with a small number of participants. The therapy may not work as hoped, and there are risks from the cell infusion and genetic modification.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for END STAGE RENAL DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Early vs Standard Catheter Removal After Kidney NCT07681843
- Combined Kidney and Bone Marrow Transplant Study NCT04571203
- Kidney Transplant Tolerance Trial (NCT03943238)
- Self-Management Program for Hemodialysis Patient NCT07677605
- Nurse-Led Program for Frailty in Peritoneal Dial NCT07677085
- Icodextrin in Incremental Peritoneal Dialysis Tr NCT05721404
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Erasmus MC, University Medical Center
Rotterdam, 3015 CN, Netherlands
-
Leiden University Medical Centre
Leiden, 2333 ZA, Netherlands
-
Oxford University Hospitals NHS Foundation Trust,
Oxford, United Kingdom
-
University Hospitals Leuven
Leuven, Belgium
-
University Medical Center Groningen
Groningen, Netherlands