END STAGE RENAL DISEASE

This phase 1 trial tests whether giving a bone marrow infusion along with a deceased donor kidney transplant can help the body accept the new kidney without needing lifelong anti-rejection drugs. The study enrolls adults with end-stage kidney disease who are already listed for a …

This study tests whether a special treatment before a kidney transplant can help the body accept the new organ without needing lifelong anti-rejection drugs. Participants receive radiation and immune-suppressing drugs, followed by an infusion of donor stem cells and the patient's…

This trial investigates whether using icodextrin, a special dialysis solution, can help people on peritoneal dialysis (a type of home dialysis for kidney failure) stay on a lower-dose regimen for longer. Participants are randomly assigned to receive either icodextrin or a standar…

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This study tests whether adding terlipressin to standard care helps maintain stable blood pressure during kidney transplant surgery. Researchers will compare two groups of 150 adults: one receiving terlipressin plus dobutamine, the other dobutamine alone. The main goal is to see …

This early-phase trial tests a combined kidney and bone marrow transplant from the same donor to help the body accept the new kidney without needing lifelong anti-rejection drugs. Up to 12 adults with kidney failure will receive the treatment. The goal is to see if this approach …

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This study looks at kidney transplant patients who take immunosuppressants to prevent organ rejection. It compares the effects of belatacept, a newer drug, against standard anticalcineurins on blood vessel function. The goal is to see if belatacept improves vascular health and re…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether a combination of belatacept and sirolimus works better than the standard drugs tacrolimus and MMF in children aged 13-20 who receive a kidney transplant. The goal is to reduce the risk of organ rejection and protect kidney function. Participants are rando…

This study tests whether giving a kidney transplant recipient blood stem cells from their sibling donor can train the body to accept the new kidney without lifelong anti-rejection drugs. Fifteen adults receiving a kidney from an identical sibling will get a conditioning regimen o…

This early-stage trial tests a new cell therapy called Eight Treg in 9 people receiving a kidney from a living donor. The therapy uses the patient's own immune cells, grown in a lab, to help the body accept the new kidney without strong anti-rejection drugs. The main goal is to c…

This phase 2 trial tests whether a single infusion of a patient's own regulatory T cells (TRK-001) can prevent the immune system from attacking a new kidney. 34 living-donor kidney transplant recipients will either receive standard anti-rejection drugs alone or those drugs plus t…

This trial tests a drug called imlifidase in highly sensitized children aged 1-17 who need a kidney transplant. The drug aims to quickly clear antibodies that would normally cause rejection, turning a positive crossmatch negative and allowing the transplant to happen. Researchers…

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This study tests whether adding sodium thiosulfate (STS) to the fluid that keeps donated kidneys cold during transport can help them work sooner after transplant. About 120 adults with kidney failure who receive a kidney from a deceased donor will take part. Half of the kidneys w…

This study tests a device called EchoMark/EchoSure that is implanted during fistula surgery for dialysis patients. The device uses automated ultrasound to monitor healing every two weeks. The goal is to see if it helps the fistula mature faster and reduces the need for additional…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease. The device is designed to remove waste and extra fluid from the blood during in-center dialysis sessions. Researchers will check how safe it is and how well it works in 46…

This study is testing a device called the WavelinQ EndoAVF System that creates a connection between an artery and a vein (AV fistula) in people who need dialysis. The goal is to make it easier to start and continue dialysis with fewer complications. About 280 adults with end-stag…

This phase 3 trial tests XyloCore, a dialysis solution with less glucose and added xylitol and L-carnitine, in 170 adults with end-stage kidney disease on continuous ambulatory peritoneal dialysis. The goal is to see if it can maintain dialysis effectiveness while improving metab…

This study tests a special silicone jacket that wraps around a donor kidney during transplant surgery to keep it warm. The goal is to see if the jacket is safe to use in different types of kidney transplants. Twenty adult recipients will be enrolled, and the study will track any …

This study compares a once-daily anti-rejection drug (Envarsus XR) to the standard twice-daily drug in 78 adults receiving a kidney transplant. The goal is to see if the once-daily option reduces hidden rejection and improves immune system markers. Participants will be followed f…

This study tests a home monitoring system called VIEWER for people with advanced chronic kidney disease (stage 5) or end-stage renal disease. The system includes a tablet, blood pressure cuff, scale, oxygen monitor, and motion tracker. Researchers want to see if using this platfo…

This study tests whether a single injection of Berinert, a protein that reduces inflammation, into a donor kidney just before transplant can improve kidney function in the first year. Researchers will compare this to a placebo in 180 high-risk patients receiving deceased-donor ki…

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study tests a blood filtering procedure called rheopheresis to treat calciphylaxis, a rare condition causing painful skin wounds in people on dialysis. About 138 participants will receive either rheopheresis or a sham procedure to see if it helps wounds heal completely withi…

This study tests three different approaches given during donor anesthesia to help the new kidney work better right after transplant. The goal is to see which method—mannitol, dopamine, or extra fluids—best improves kidney function. The study involves 60 adults with end-stage kidn…

This phase 3 trial compares two common beta blockers—metoprolol and carvedilol—in about 2,540 hemodialysis patients. The goal is to see if metoprolol, which is removed by dialysis, leads to fewer major heart events like heart attacks, strokes, or heart failure hospitalizations. P…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This study looks at whether adding CoQ10 (a supplement that supports cell energy) to high-intensity interval training can help people with end-stage kidney disease build muscle and improve physical function. 156 adults on dialysis will be assigned to exercise alone or exercise pl…

This phase 2 study tests a drug called nedosiran (DCR-PHXC) in 28 people with primary hyperoxaluria type 1 (PH1) who have severe kidney impairment, with or without dialysis. The goal is to see if the drug safely lowers plasma oxalate levels, which can cause kidney stones and dama…

This study tests whether a personalized sodium (salt) management feature on dialysis machines can help people with end-stage kidney disease. It compares the new approach to standard dialysis in 130 adults. The goal is to see if it reduces weight gain between sessions, improves fl…

This early-phase trial tests whether a stomach acid drug called vonoprazan fumarate can reduce delayed graft function, a common complication where a new kidney doesn't work right away. About 47 first-time kidney transplant recipients will take the drug for seven days after surger…

This study tests whether giving a donor kidney a 4-6 hour warm bath on a machine (normothermic machine perfusion) right before transplant helps it work better a year later. The trial includes 240 adults receiving a kidney from a donor aged 50 or older. Half get the standard cold …

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study tests whether exercising during dialysis, with or without a blood flow restriction cuff, can reduce heart strain and improve heart function in kidney patients. About 108 adults on dialysis will be randomly assigned to standard care, exercise alone, or exercise with blo…

This study tests whether empagliflozin, a diabetes medicine, is safe and helps control body fluid levels in 60 adults who are starting hemodialysis for end-stage kidney disease. Participants will take either empagliflozin or a placebo for 12 weeks. The goal is to see if the drug …

This study tests a device called VasQ that is placed around a blood vessel connection (fistula) used for dialysis in people with kidney failure. The goal is to see if VasQ helps the fistula work well enough for dialysis sooner and for longer compared to standard fistula creation.…

This study tests a device that helps people on dialysis get needles into their fistula more easily. It is for patients whose fistula is too deep for standard needle sticks. The study will check if the device works well and is safe over 6 to 12 months. About 100 adults will take p…

This study looks at whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive recipients. Researchers will follow 30 adults with HIV and end-stage kidney disease who receive a kidney from an HIV-positive donor. The goal is to learn more about pat…

This study tests a new feature on a dialysis machine that tries to predict and prevent sudden drops in blood pressure during treatment. About 56 adults on long-term dialysis who often have low blood pressure will be randomly assigned to use the feature or not, then switch. The go…

This study tests whether a device that measures brain waves (called BIS) can detect dialysis disequilibrium syndrome, a complication that can occur during first-time dialysis. Twenty new dialysis patients will be monitored during their first three sessions. The goal is to see if …

This study looks at whether a special ultrasound inside the vein (IVUS) can find blockages better than the usual X-ray method in people on dialysis. About 50 adults with kidney failure who have trouble with their dialysis access will take part. The goal is to see if IVUS gives cl…

This pilot study tests a 13-week Dialectical Behavioural Therapy (DBT) skills training program for Canadians who have recently started or will soon start facility-based hemodialysis. The goal is to see if the program is feasible and helpful for improving mental health and reducin…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and cope better with stress. About 60 adults will use personalized relaxation techniques guided by AI during their dialysis sessions. Researchers will measure changes in…

This study is testing whether a new type of dialyzer, called Theranova, can help reduce common symptoms like pain, fatigue, and poor sleep in people with end-stage renal disease who are on dialysis. About 100 participants will use their usual dialyzer for the first 4 weeks and th…

This study tests whether a 15-20 minute session in a specially designed sensory modulation room before kidney transplant surgery can reduce pain, anxiety, and sleep problems afterward. The room has dim lights, nature videos, calming music, and tactile objects like stress balls. R…

This study tests whether a nerve block called transversalis fascia plane block can reduce pain after kidney transplant surgery. Fifty adults will receive either the nerve block plus standard painkillers or standard painkillers alone. The goal is to see if the block lowers pain sc…

This study tests whether a drug called icatibant can prevent sudden drops in blood pressure during dialysis, a common and serious problem. About 26 adults with kidney failure who often experience these drops will receive either the drug or a placebo in random order. The goal is t…

This study tests whether having dialysis patients report their symptoms every month – and automatically alerting their care team when symptoms are severe – can improve their quality of life. About 2,293 adults with end-stage kidney disease on dialysis will take part across French…

This early-phase study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. Researchers will compare a single amino acid (valine) with a mix of essential amino acids in 28 adults on …

This study tests whether a 6-week aerobic exercise program (done on non-dialysis days) can lower serum uric acid levels, improve walking ability, and boost quality of life in 32 adults aged 40-60 who are on hemodialysis. Half will exercise 3 times a week; the other half will rece…

This study tests whether applying magnetic stimulation can help relieve low back pain and maintain muscle mass in people with end-stage kidney disease who are on dialysis. Researchers will measure pain levels, physical function, and quality of life in 18 adult participants. The g…

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This early-stage study looks at how safe a new drug called INCB123667 is for people with severe kidney disease or kidney failure. Researchers will measure how the drug moves through the body and check for side effects. The study involves 16 adults aged 18 to 85.

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This study follows 100 adults with end-stage kidney disease who need long-term dialysis but have no working access sites left. Researchers are watching how well the HeRO and Super HeRO grafts perform over two years, checking for infections, blockages, and overall safety. The goal…

This study at Yale University is testing whether the body can store sodium without holding onto extra water, a concept called 'water-free sodium storage.' Ten adults on peritoneal dialysis with heart failure will receive either a special dextrose solution or standard dialysis flu…

This study tests whether community health workers and special training for doctors can help more kidney patients get on the transplant waitlist. Five patients will be assigned to either usual care or extra support from a community health worker who addresses social needs like hou…

This study tests whether a nurse-led foot care education program, based on the Health Belief Model, can improve foot care knowledge and behavior in diabetic patients undergoing hemodialysis. Fifty participants will be randomly assigned to receive the training or standard care. Th…

This study tests whether a simple neck ultrasound can accurately measure fluid status in people receiving chronic haemodialysis. Researchers will compare ultrasound results with standard methods in 100 participants. The goal is to find a safer, non-invasive way to guide fluid rem…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome affects the way the body processes drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation markers and estimate how they mig…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study reviews medical records of 10 adult transplant patients who have a hard-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. No new treatments or procedures are given; the …

This study looks at whether using a lower amount of bicarbonate in the dialysis fluid is better for the heart than the usual higher amount. About 141 hospitalized adults on long-term dialysis will be randomly assigned to receive either lower or higher bicarbonate during their dia…

This study looks at why some kidney transplant patients, especially those with a kidney disease called FSGS, develop protein in their urine again after surgery. Researchers will examine blood and kidney tissue samples taken before and after the transplant to find the cause. The g…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study is testing a new blood test that looks for kidney-specific DNA to detect injury or rejection after a kidney transplant. Researchers will measure these DNA markers before and after surgery in 30 patients with end-stage kidney disease. The goal is to see if the test can …

This study looks at how the body controls sodium levels in people with end-stage kidney disease who are on dialysis. Researchers will give participants either water or a concentrated salt solution to see how their sodium levels change. The goal is to better understand hyponatremi…

This study looks at whether the sounds made by blood flowing through an arteriovenous fistula (AVF) can tell doctors how healthy the fistula is. Researchers will use MRI and ultrasound to measure blood flow and compare it to the sounds recorded. If a clear link is found, it could…