END STAGE RENAL DISEASE

This study tests an experimental drug called DCR-PHXC in people with primary hyperoxaluria type 1 (PH1) who have severe kidney damage, whether or not they are on dialysis. The goal is to see if the drug can safely lower oxalate levels in the blood, which may help control the dise…

This study tests whether a blood-filtering procedure called rheopheresis can help heal severe skin wounds caused by calciphylaxis, a rare complication in people on dialysis. About 138 adults with end-stage kidney disease and at least one open wound will receive either standard ca…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease. The goal is to see if it safely and effectively removes waste from the blood during in-center dialysis sessions. About 46 adults who are either new to dialysis or already …

This study tests whether a personalized sodium management feature on dialysis machines can improve fluid balance and reduce complications like blood pressure swings and cramping. About 130 adults with end-stage kidney disease will be randomly assigned to receive either standard d…

This study tests a special wrap called SelfWrap placed around blood vessels during fistula creation for dialysis. The goal is to help the fistula mature faster and work without extra procedures. About 600 adults with chronic kidney disease needing a new fistula will take part. Th…

This study compares two common heart medications, metoprolol and carvedilol, in people on hemodialysis. The goal is to see which one better prevents major heart events like heart attacks, strokes, heart failure, and death. About 2,540 participants will be randomly assigned to one…

This study tests a new automated ultrasound system (EchoMark/EchoSure) to see if it can help arteriovenous fistulas mature faster in people with end-stage kidney disease and diabetes. About 304 adults will be randomly assigned to get biweekly automated scans or standard care. The…

This study compares a once-daily anti-rejection drug (Envarsus XR) to a twice-daily drug (tacrolimus) in 78 adults receiving a first kidney transplant. The goal is to see if Envarsus XR reduces hidden rejection and improves immune system markers in the blood. Participants will be…

This study is testing a device called the BD WavelinQ EndoAVF System, which creates a connection between an artery and a vein (called an AV fistula) in people with kidney failure who need dialysis. The goal is to see if this device helps make dialysis treatments more successful a…

This study tests whether empagliflozin, a drug used for diabetes, is safe and helps control fluid balance in people who are starting hemodialysis for end-stage kidney disease. About 60 adults will receive either empagliflozin or a placebo for 12 weeks. The goal is to see if the d…

This study tests whether adding CoQ10 (a supplement) to high-intensity interval training helps improve muscle function in people with end-stage kidney disease on dialysis. Researchers believe that mitochondrial problems limit the benefits of exercise alone. 156 adults aged 18-75 …

This study tests a device called VasQ, which is placed around a blood vessel connection (fistula) used for dialysis. The goal is to see if it helps the fistula work well enough for dialysis sooner and more reliably. The study will include 300 adults with end-stage kidney disease …

This study tests a new way to remove fluid during dialysis by using a patient's recent blood pressure patterns to guide how much fluid is taken out. The goal is to reduce dangerous low blood pressure episodes during treatment while still controlling fluid buildup. About 69 vetera…

This study tests whether kidney transplants from HIV-positive donors are safe and effective for people with HIV who also have kidney failure. About 30 adults with well-controlled HIV will receive a kidney from an HIV-positive donor. Researchers will track survival and kidney func…

This study tests a special app and home monitoring system for people with advanced chronic kidney disease (stage 5 or end-stage). The goal is to see if using the app helps reduce emergency room visits and hospital stays compared to standard care alone. About 340 adults in Canada …

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). Participants receive either the drug or a placebo after surgery. …

This study tests a new dialysis solution called XyloCore, which uses less glucose than standard fluids. It is for adults with end-stage kidney disease who are on continuous ambulatory peritoneal dialysis. The goal is to see if XyloCore can clean the blood as well as current solut…

This study looks at whether a special ultrasound placed inside the vein (IVUS) can better detect blockages than the standard X-ray method in people on dialysis. About 50 adults with kidney failure who have dialysis access problems will take part. The goal is to see if IVUS gives …

This study tests whether wearing special glasses that emit bright light during dialysis sessions can reduce severe fatigue in people with end-stage kidney disease. Sixty adults on hemodialysis will use the light therapy for one hour per session over four weeks. The goal is to see…

This study tests whether regularly monitoring symptoms in dialysis patients and automatically notifying their care teams can improve quality of life. About 2,293 adults with end-stage kidney disease will participate across French dialysis centers. The goal is to help doctors addr…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again. It focuses on solving barriers like frailty, depression, or lack of support. The study includes 43 adults and will see if the program improves waitlist statu…

This study tests whether magnetic stimulation can help relieve low back pain and maintain muscle mass in people with end-stage renal disease who are on dialysis. About 18 adults with moderate to severe back pain will receive the treatment. The goal is to see if this non-invasive …

This study tests whether taking amino acid supplements during dialysis can help reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. About 28 adults on dialysis will take either a single amino acid (valine) or a mix of essential amino acids. The …

This study is a large registry that will collect health information from up to 60,000 patients with both heart and kidney disease. The goal is to better understand how these conditions interact and what factors affect patient outcomes. No new treatments are being tested; instead,…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome can change the way the body processes certain drugs. Researchers will measure inflammation markers and immune cells in blood samples from 150 adults and children with …

This study is testing a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. About 1,000 adults on…

This study looks at whether the sound made by an arteriovenous fistula (a surgically created connection between an artery and a vein used for dialysis) can tell doctors about blood flow conditions inside it. Researchers will measure sound patterns and compare them to ultrasound i…

This study looks at how the drug MK-2828 behaves in the bodies of people with different levels of kidney function, including those on dialysis. About 24 adults will receive one or two doses, and researchers will track the drug levels in their blood over time. The goal is to see i…