Could a bone marrow infusion help kidney transplant patients ditch lifelong pills?
NCT ID NCT04571203
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This phase 1 trial tests whether giving a bone marrow infusion along with a deceased donor kidney transplant can help the body accept the new kidney without needing lifelong anti-rejection drugs. The study enrolls adults with end-stage kidney disease who are already listed for a transplant. Participants receive a special conditioning regimen with low-dose radiation and an immune-suppressing drug to encourage the donor bone marrow cells to engraft and create immune tolerance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Combined deceased donor kidney and hematopoietic cell transplant with radiation and anti-thymocyte globulin (ATG)
What this could lead to
If successful, this approach could allow kidney transplant recipients to take fewer or no lifelong anti-rejection medications, improving quality of life.
What could go wrong
This is an early phase 1 study with only 30 participants, so results may not apply broadly. Risks include graft-versus-host disease, infections, and failure to achieve immune tolerance.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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MSOB
RECRUITINGStanford, California, 94305, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University
RECRUITINGPalo Alto, California, 94305, United States