Could a bone marrow infusion help kidney transplant patients ditch lifelong pills?

NCT ID NCT04571203

Recruiting now Disease control Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This phase 1 trial tests whether giving a bone marrow infusion along with a deceased donor kidney transplant can help the body accept the new kidney without needing lifelong anti-rejection drugs. The study enrolls adults with end-stage kidney disease who are already listed for a transplant. Participants receive a special conditioning regimen with low-dose radiation and an immune-suppressing drug to encourage the donor bone marrow cells to engraft and create immune tolerance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combined deceased donor kidney and hematopoietic cell transplant with radiation and anti-thymocyte globulin (ATG)
What this could lead to: If successful, this approach could allow kidney transplant recipients to take fewer or no lifelong anti-rejection medications, improving quality of life.
What could go wrong: This is an early phase 1 study with only 30 participants, so results may not apply broadly. Risks include graft-versus-host disease, infections, and failure to achieve immune tolerance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNE TOLERANCE

Contacts and locations

Locations

MSOB
RECRUITING

Stanford, California, 94305, United States
Stanford University
RECRUITING

Palo Alto, California, 94305, United States

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