New dialysis fluid aims to cut sugar side effects

NCT ID NCT03994471

Recruiting now Disease control Sponsor: Iperboreal Pharma Srl Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests XyloCore, a dialysis solution with less glucose and added xylitol and L-carnitine, in 170 adults with end-stage kidney disease on continuous ambulatory peritoneal dialysis. The goal is to see if it can maintain dialysis effectiveness while improving metabolic health markers like blood sugar and cholesterol over 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XyloCore (a mix of xylitol, low glucose, and L-carnitine)
What this could lead to: If it works, this could offer a gentler dialysis option that reduces glucose-related side effects like high blood sugar and cholesterol.
What could go wrong: This is a mid-stage trial with only 170 participants, so results may not apply to everyone. The new solution might not work as well as standard glucose solutions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END-STAGE RENAL DISEASE

Contacts and locations

Locations

AOU Università degli studi della Campania
RECRUITING

Naples, Italy
ASST Fatebenefratelli-Sacco -Ospedale Luigi Sacco
RECRUITING

Milan, Italy
ASST Spedali Civili di Brescia
NOT_YET_RECRUITING

Brescia, Italy
Aalborg University
NOT_YET_RECRUITING

Aalborg, Denmark
Aarhus University Hospital
RECRUITING

Aarhus, Denmark
Azienda Ospedaliera Terni
RECRUITING

Terni, Italy
Azienda Ospedaliera Universitaria Integrata di Verona
RECRUITING

Verona, Italy
Azienda Ospedaliera Universitaria di Modena
RECRUITING

Modena, Italy
Azienda Ospedaliera di Padova
NOT_YET_RECRUITING

Padova, Italy
Azienda Universitaria Ospedaliera di Bari
RECRUITING

Bari, Italy
Churchill Hospital
RECRUITING

Oxford, United Kingdom
Dialysis Center DaVita
RECRUITING

Düsseldorf, Germany
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
NOT_YET_RECRUITING

Milan, Italy
Fundacion Jimenez Diaz
RECRUITING

Madrid, Spain
Fundaciòn Puigvert
RECRUITING

Barcelona, Spain
Halland County Hospital of Halmstad
RECRUITING

Halmstad, Sweden
Hammersmith Hospital
RECRUITING

London, United Kingdom
Heartlands Hospital
RECRUITING

Birmingham, United Kingdom
Hospital Ramón y Cajal
NOT_YET_RECRUITING

Madrid, Spain
Hospital U. Germans Trias i Pujol
RECRUITING

Badalona, Spain
Hospital Universitario Central De Asturias
RECRUITING

Oviedo, Spain
Hospital Universitario Josep Trueta
RECRUITING

Girona, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Spain
IRCCS Policlinico San Martino
NOT_YET_RECRUITING

Genova, Italy
Karolinska University Hospital
RECRUITING

Stockholm, Sweden
Kent and Canterbury Hospital
RECRUITING

Canterbury, United Kingdom
Ospedale AUSL "Guglielmo da Saliceto"
RECRUITING

Piacenza, Italy
Ospedale C. e G. Mazzoni
RECRUITING

San Benedetto del Tronto, Italy
Ospedale Civile San Salvatore
RECRUITING

L’Aquila, Italy
Ospedale Madonna del Soccorso
RECRUITING

Ascoli Piceno, Italy
Ospedale S.Eugenio
NOT_YET_RECRUITING

Roma, Italy
Ospedale SS. Annunziata
RECRUITING

Chieti, Italy
Ospedale San Giovanni Bosco
RECRUITING

Torino, Italy
Ospedale Santa Maria Annunziata
NOT_YET_RECRUITING

Bagno a Ripoli, Italy
Sheffield Kidney Institute
RECRUITING

Sheffield, United Kingdom
St Luke's Hospital
RECRUITING

Bradford, United Kingdom
University Hospital A Coruña Fundación Profesor Novoa Santos
RECRUITING

A Coruña, Spain
University Hospitals Sussex
RECRUITING

Brighton, United Kingdom
University Hospitals of North Midlands
RECRUITING

Stoke-on-Trent, United Kingdom
Università della Campania L.Vanvitelli
RECRUITING

Naples, Italy
Zealand University Hospital
RECRUITING

Roskilde, Denmark

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