Dialysis heart risk: which beta blocker wins?

NCT ID NCT05931276

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial compares two common beta blockers—metoprolol and carvedilol—in about 2,540 hemodialysis patients. The goal is to see if metoprolol, which is removed by dialysis, leads to fewer major heart events like heart attacks, strokes, or heart failure hospitalizations. Participants are already on one of these drugs and will be randomly assigned to continue with metoprolol or switch to carvedilol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: metoprolol succinate and carvedilol
What this could lead to: If metoprolol works better, it could reduce heart attacks, strokes, and deaths in dialysis patients.
What could go wrong: This is a large trial but still uncertain; results may not apply to all patients, and both drugs have known side effects like low blood pressure or fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder chronic kidney disease end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END STAGE KIDNEY DISEASE END-STAGE RENAL DISEASE

Contacts and locations

Locations

Atlanta VA Medical and Rehab Center, Decatur, GA
RECRUITING

Decatur, Georgia, 30033-4004, United States
Iowa City VA Health Care System, Iowa City, IA
RECRUITING

Iowa City, Iowa, 52246-2292, United States
Minneapolis VA Health Care System, Minneapolis, MN
RECRUITING

Minneapolis, Minnesota, 55417-2309, United States
New Mexico VA Health Care System, Albuquerque, NM
RECRUITING

Albuquerque, New Mexico, 87108-5153, United States
North Florida/South Georgia Veterans Health System, Gainesville, FL
RECRUITING

Gainesville, Florida, 32608-1135, United States
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
RECRUITING

Omaha, Nebraska, 68105-1850, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
NOT_YET_RECRUITING

Boston, Massachusetts, 02130-4817, United States
VA Long Beach Healthcare System, Long Beach, CA
RECRUITING

Long Beach, California, 90822, United States

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