New drug could unlock kidney transplants for sensitized kids

NCT ID NCT05753930

Recruiting now Disease control Sponsor: Hansa Biopharma AB Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests a drug called imlifidase in highly sensitized children aged 1-17 who need a kidney transplant. The drug aims to quickly clear antibodies that would normally cause rejection, turning a positive crossmatch negative and allowing the transplant to happen. Researchers will check if the drug works and how well the new kidney functions over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: imlifidase
What this could lead to: If it works, this could help highly sensitized children receive a kidney transplant that would otherwise be impossible due to immune rejection.
What could go wrong: This is a small, early-phase trial with only 10 participants. The drug may not work for all, and there are risks from the transplant and immune-suppressing medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANTATION IN HIGHLY SENSITIZED PATIENTS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Great Ormond Street Hospital for Children NHS Foundation Trust
RECRUITING

London, WC1N 3JH, United Kingdom
HUS, Helsinki University Hospital
WITHDRAWN

Helsinki, 00290, Finland
Hospital Unviersitari Vall d'Hebron, Nefrología Pediátrica
RECRUITING

Barcelona, 08035, Spain
Karolinska University Hospital
RECRUITING

Huddinge, Stockholm County, SE-141 86, Sweden
Robert Debre University Hospital
RECRUITING

Paris, 75019, France

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