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Could pumpkin seed oil ease inflammation in dialysis patients?

NCT ID NCT07710183

Disease control Sponsor: Al-Mustansiriyah University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether taking pumpkin seed oil daily for three months can reduce inflammation and oxidative stress in people with end-stage kidney disease who are on hemodialysis. The oil is rich in healthy fats and antioxidants. Researchers will measure changes in blood markers of inflammation and heart risk compared to standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pumpkin seed oil, 1000 mg oral capsule taken once daily for 3 months
What this could lead to
If it works, this could point toward a simple, low-cost supplement to help manage inflammation and heart disease risk in people on dialysis.
What could go wrong
This is a small, early-stage trial with only 85 participants over 3 months. The supplement may not show meaningful benefits, and results may not apply to all dialysis patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * End-stage renal disease (ESRD) on hemodialysis for more than 6 months, on a constant dialysis program. * Hemodynamically stable (no recent hospitalization for infections, cardiovascular events, or major surgery within the past 3 months). * No active acute infections. * Serum albumin ≥ 3.0 g/dL. Exclusion Criteria: * Regular intake of dietary supplements (e.g., omega-3, antioxidants) for at least one month prior to enrollment. * Autoimmune disease, liver disease, cancer, or acquired immunodeficiency syndrome (AIDS). * Known sensitivity/allergy to pumpkin seed oil. * Current use of lipid-lowering agents. * Diabetes mellitus. * Current use of anticoagulants (warfarin, direct oral anticoagulants). * Current use of immunosuppressants, corticosteroids, or anti-inflammatory drugs. * Pregnant or breastfeeding women. * Residual kidney function (urine output \> 200 mL/day).

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease requiring chronic dialysis End stage renal disease Inflammation Oxidative stress

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Al-Karama Teaching Hospital, Hemodialysis Center

    RECRUITING

    Baghdad, Karkh, 10064, Iraq

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