A simple blood test could spot kidney transplant rejection early

NCT ID NCT06351488

Recruiting now Diagnosis Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study is testing whether a blood or urine test can detect kidney transplant rejection earlier and more easily than the current standard, which requires a biopsy. The test looks for DNA from the transplanted kidney in the blood or urine, which may increase when rejection occurs. The study involves 319 kidney transplant patients who are already scheduled for a biopsy, and the test results will be compared to the biopsy findings to see if the test is accurate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A blood and urine test that looks for DNA from the transplanted kidney to detect rejection early.
What this could lead to: If successful, this could lead to a simple blood or urine test to detect kidney transplant rejection early, potentially reducing the need for invasive biopsies.
What could go wrong: This is an early-stage study, and the test may not be accurate enough to replace biopsies. It is also unclear if the results will apply to all types of rejection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Rejection, Psychology transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANT REJECTION

Contacts and locations

Locations

Assistance Publique - Hôpitaux de Paris, Hôpital Necker
RECRUITING

Paris, 75013, France
Assistance Publique - Hôpitaux de Paris, Hôpital Tenon
NOT_YET_RECRUITING

Paris, 75020, France
Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière hospital
ACTIVE_NOT_RECRUITING

Paris, 75013, France

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