KIDNEY TRANSPLANT

This phase 3 trial tests whether ravulizumab, given intravenously, can reduce the severity of delayed graft function (DGF) in adults at high risk after kidney transplant. DGF is when the new kidney is slow to start working, often requiring dialysis. The study will compare ravuliz…

This study tests whether adding terlipressin to standard care helps maintain stable blood pressure during kidney transplant surgery. Researchers will compare two groups of 150 adults: one receiving terlipressin plus dobutamine, the other dobutamine alone. The main goal is to see …

This study tests whether a new type of immunotherapy called CAR T cells can safely lower the immune system's reactivity in people waiting for a kidney transplant. Participants have a very high chance of rejecting most donor kidneys (cPRA of 99.5% or higher). The treatment involve…

This study tests whether a combination of belatacept and sirolimus works better than the standard drugs tacrolimus and MMF in children aged 13-20 who receive a kidney transplant. The goal is to reduce the risk of organ rejection and protect kidney function. Participants are rando…

This study tests whether giving a kidney transplant recipient blood stem cells from their sibling donor can train the body to accept the new kidney without lifelong anti-rejection drugs. Fifteen adults receiving a kidney from an identical sibling will get a conditioning regimen o…

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests whether adding sodium thiosulfate (STS) to the fluid that keeps donated kidneys cold during transport can help them work sooner after transplant. About 120 adults with kidney failure who receive a kidney from a deceased donor will take part. Half of the kidneys w…

This study tests a special silicone jacket that wraps around a donor kidney during transplant surgery to keep it warm. The goal is to see if the jacket is safe to use in different types of kidney transplants. Twenty adult recipients will be enrolled, and the study will track any …

This phase 3 study tests VX-880, a stem-cell therapy infused into the liver, in 10 people with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop using insulin entirely. The therapy is given alongside standard transplan…

This study looks at whether switching kidney transplant patients from a standard drug (tacrolimus) to abatacept can improve kidney function and quality of life. It involves 800 participants, with 300 randomly assigned to either the new drug or standard care. The goal is to see if…

This study tests whether a single injection of Berinert, a protein that reduces inflammation, into a donor kidney just before transplant can improve kidney function in the first year. Researchers will compare this to a placebo in 180 high-risk patients receiving deceased-donor ki…

This study tests whether stem cells from donated bone marrow are safe for people with chronic kidney disease, including those who have had a kidney transplant. Up to 75 participants will receive the cells through an IV or directly into the kidney arteries, with repeat doses allow…

This study tests whether a doctor-led counseling program, combined with two smartphone apps (Nutrida and Gamebus), can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first receive lifestyle advice, then use…

This study tests two new imaging techniques—ultrasound localization microscopy and multispectral optoacoustic tomography—to check the health of kidney transplants without invasive procedures. Ten adult kidney transplant patients who already need a biopsy will also get these scans…

This study is testing whether advanced, non-contrast MRI scans can safely and accurately monitor the health of transplanted kidneys. Currently, doctors rely on blood tests and invasive biopsies, which can miss early signs of trouble. Researchers will scan 1000 participants, inclu…

This study compares a new drug called leymovir to the standard drug valganciclovir for preventing cytomegalovirus (CMV) infection in 290 Chinese kidney transplant recipients. Leymovir targets a different part of the virus, which may reduce side effects like bone marrow suppressio…

This study explores whether artificial intelligence can create personalized stories to help children aged 5 to 12 who have received a kidney transplant. The stories are designed to address the emotional and social challenges these children face. Researchers will ask families abou…

This study compares two anesthesia methods—general anesthesia with sevoflurane and combined spinal-epidural anesthesia—in adults receiving a kidney transplant. Researchers will measure blood markers related to cell damage and protection to see if one method better shields the new…

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study surveys 1,000 kidney transplant recipients in France and the U.S. to learn their thoughts on using artificial intelligence to predict whether a transplanted kidney might fail. Participants fill out an online questionnaire about their hopes, worries, and how AI predicti…

This study looks at why some kidney transplant patients develop blood sugar problems like diabetes. It focuses on how the body processes the drug tacrolimus, which helps protect the new kidney but can also raise blood sugar. Researchers will follow 120 adults in Poland to find ou…

This study is tracking 200 kidney transplant patients in Scotland to see if certain biomarkers can help predict transplant rejection. Researchers will compare biomarker levels with standard biopsy results. The goal is to find a simpler, less invasive way to monitor transplant hea…

This study looks at the long-term health of children (16 years and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's transplant or medications.…

This study collects blood samples from 400 kidney transplant patients who need a biopsy. Researchers will use the samples to develop a non-invasive test that measures donor DNA in the blood to check the health of the transplanted kidney. The goal is to replace invasive biopsies w…

This study explores whether a special type of MRI, called manganese-enhanced MRI, can help identify people with kidney disease who are at risk for heart problems. Researchers will scan the heart and kidneys of 120 adults with various kidney conditions, including acute kidney inju…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study follows 30 adults who recently received a kidney transplant to see how their overall health, heart disease risk, and other medical conditions change over one year. Researchers will measure blood pressure, weight, fitness, and lab results at several visits. There is no …