KIDNEY TRANSPLANT

This study tests whether adding sodium thiosulfate to the fluid that keeps donated kidneys cold during transport can reduce damage and help the kidney work right away after transplant. About 120 adults receiving a deceased-donor kidney will take part. Half will get the standard p…

This study involves 200 children aged 13-20 who are receiving a kidney transplant. Researchers are comparing a new combination of immunosuppressive drugs (belatacept and sirolimus) with the standard combination (tacrolimus and MMF) to see which better prevents the body from attac…

This study is testing whether a diabetes drug called empagliflozin is safe for people who have received a kidney transplant. The drug has been shown to protect the heart and kidneys in other patients, but transplant recipients were left out of earlier studies due to safety concer…

This study tests if a drug called terlipressin can better manage blood pressure during kidney transplant surgery compared to standard care. The goal is to see if it helps the new kidney work right away and reduces the need for dialysis after surgery. About 150 adults with end-sta…

This study tests a drug called sparsentan for people who have protein in their urine after a kidney transplant due to IgA nephropathy or FSGS. About 20 adults will take the drug once daily for 36 weeks to see if it safely reduces protein levels and protects kidney function. The g…

This study involves 800 adult first-time kidney transplant recipients. Researchers will use a biomarker (HLA-DR/DQ molecular mismatch score) to identify those at higher risk of rejection. Six months after transplant, 300 eligible participants will be randomly assigned to switch f…

This study tests whether bone marrow stem cells are safe for people with chronic kidney disease, including those who have had a kidney transplant. About 75 adults will receive stem cells through a vein or directly into the kidney arteries. The goal is to monitor side effects, not…

This study tests a special jacket that keeps donated kidneys warm during transplant surgery. The goal is to see if the jacket is safe for different types of kidneys and patients. About 20 adults getting their first or second kidney transplant will take part. Researchers will watc…

This study tests whether injecting Berinert (a C1 esterase inhibitor) directly into a deceased donor kidney before transplant can improve kidney function one year later. About 180 adults on dialysis awaiting a kidney transplant will receive either Berinert or a placebo. The goal …

This study tests if the drug ravulizumab can help transplanted kidneys start working sooner, reducing the need for dialysis after surgery. About 450 adults at high risk for delayed graft function will receive either the drug or a placebo. The main goal is to see how quickly patie…

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This early-stage study tests whether injecting donor stem cells directly into the artery of a transplanted kidney is safe and can reduce inflammation from rejection. It involves 12 adult kidney transplant recipients who have signs of rejection on biopsy. The goal is to see if thi…

This phase 3 study tests VX-880, a cell therapy, in 10 adults with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop taking insulin while staying on lifelong anti-rejection drugs. The study will measure insulin indepen…

This study tests a new approach to help kidney transplant recipients accept their new organ without needing lifelong anti-rejection medication. Participants receive a special combination of radiation and a drug, followed by a stem cell infusion from the same sibling who donated t…

This study tests a new drug, leymovir, against the standard drug valganciclovir to prevent cytomegalovirus (CMV) infection in 290 Chinese kidney transplant recipients. Leymovir works differently and may cause fewer side effects like low white blood cell counts and kidney damage. …

This study explores whether artificial intelligence can create personalized stories to help children aged 5 to 12 who have received a kidney transplant. The goal is to ease the emotional and social challenges they face. Researchers will ask families about their experience with th…

This study tests if a doctor-led counseling program, plus two smartphone apps, can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The main goal is…

This study tests two new imaging methods—ultrasound localization microscopy and multispectral optoacoustic tomography—to check the health of kidney transplants without needing a biopsy. Ten adult kidney transplant patients who already need a biopsy will be scanned to see if these…

This study follows 30 adults who recently received a kidney transplant to track changes in their health over one year. Researchers will measure heart disease and stroke risk factors, such as blood pressure and cholesterol, along with physical fitness and other medical conditions.…

This study explores whether a special type of MRI, called manganese-enhanced MRI (MEMRI), can help detect early signs of heart and kidney problems in people with various kidney diseases, including acute kidney injury, chronic kidney disease, and kidney transplant. Researchers wil…

This study explores a new, non-invasive MRI technique to monitor kidney transplant function. Instead of relying on blood tests or invasive biopsies, the MRI measures blood flow and oxygen levels in the kidney. The study will enroll about 1,000 participants, including transplant d…

This study follows 200 kidney transplant patients in Scotland to see if certain biomarkers can help predict transplant rejection. Researchers will collect urine samples and track health outcomes during routine follow-up visits. The goal is to improve how doctors monitor and manag…

This study is for adults who have received a kidney transplant and take the drug tacrolimus to protect their new kidney. The goal is to understand why some patients develop blood sugar problems like prediabetes or diabetes. Researchers will look at how quickly each person's body …

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers want to see if getting a new kidney improves blood flow to the heart and reduces inflammation. Participants will have heart scans and blood tests before and …

This study collects blood samples from 400 kidney transplant patients to help develop a non-invasive test that detects donor DNA in the blood. The test aims to monitor the health of the transplanted kidney without needing a biopsy. Participants must be 18 or older, have had a kid…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…