KIDNEY TRANSPLANT

This study is testing a new treatment to help kidney transplant patients accept their new organ and potentially stop taking anti-rejection drugs for good. It involves a special radiation treatment and an infusion of stem cells from the same sibling who donated the kidney. The goa…

This study has two main parts. First, it will follow 800 new kidney transplant patients to see if a new blood test can predict who is at higher risk for organ rejection. Second, for 300 of the most stable patients, it will test if switching from the standard anti-rejection drug t…

This study is testing whether a medication called sparsentan can safely reduce protein in the urine of kidney transplant patients whose original kidney disease has returned. About 20 adult participants who received a transplant at least one year ago will take the daily tablet for…

This study is testing whether a doctor-led lifestyle counseling program, combined with two personalized smartphone apps, is practical and helpful for older adults who have received a liver or kidney transplant. Participants first receive 12 weeks of medical advice on healthy eati…

This early-stage study is testing a new cell therapy for people who have been waiting over a year for a kidney transplant and have immune systems that would reject almost any donor kidney. Researchers will collect a patient's own immune cells, modify them in a lab to target antib…

This study is testing an investigational cell therapy called VX-880 in people who have type 1 diabetes and have already received a kidney transplant. The main goal is to see if the treatment can help participants stop needing insulin injections. Participants must already be on st…

This study is testing the safety of a special cooling jacket used during kidney transplant surgery. The jacket is designed to keep the donor kidney cold while surgeons connect it to the recipient's blood vessels, which may help prevent damage to the new organ. Researchers will en…

This early-stage study is testing whether a new treatment is safe for people whose body is rejecting a transplanted kidney. Doctors will infuse special cells, taken from donor fat tissue, directly into the artery of the transplanted kidney. The main goal is to see if this procedu…

This study is testing whether stem cells taken from bone marrow are safe for people with chronic kidney disease, including those who have had a kidney transplant. Researchers will give these cells to 75 adults and closely monitor them for any side effects. The goal is to see if t…

This study aims to find a better way to prevent rejection in young people who receive a kidney transplant. It will compare the safety and effectiveness of two different combinations of anti-rejection drugs. The goal is to see which regimen better protects the new kidney's functio…

This study is testing whether an intravenous medication called ravulizumab can help a newly transplanted kidney start working properly sooner in patients at high risk for complications. It will involve 450 adults receiving a kidney from a deceased donor who are likely to experien…

This study is testing whether injecting a medication called Berinert directly into a donated kidney during transplant surgery can help the kidney work better in the first year after transplant. Researchers will compare Berinert to a placebo in 180 adults receiving high-risk decea…

This study is testing a new type of MRI scan to check the health of transplanted kidneys without needles, contrast dye, or invasive biopsies. It aims to create a personalized 'baseline' for each kidney by scanning donors before donation, allowing for more sensitive, early detecti…

This study is testing two new, non-invasive imaging techniques to monitor the health of a transplanted kidney. The goal is to see if these scans can provide the same information as a standard, invasive kidney biopsy, which carries risks like bleeding. Researchers will enroll 10 a…

This study is testing a new drug called leymovir to prevent cytomegalovirus (CMV) infection in people who have recently received a kidney transplant. It will compare leymovir to the current standard drug, valganciclovir, in 290 Chinese patients to see if it works as well and is s…

This study aims to understand how the health of people who receive a kidney transplant changes during the first year. Researchers will observe 30 adult patients to learn about their risk for heart disease and stroke, and how multiple health conditions develop. The study involves …

This study aims to collect blood samples from 400 people who have received a kidney transplant. The goal is to use these samples to help develop a new, non-invasive blood test. This future test would check for signs of organ rejection or other problems without always needing a bi…

This study aims to understand the long-term health of children born to mothers who have had a solid organ transplant (like kidney, liver, or heart). Researchers want to see if these children have a higher risk of heart, kidney, or immune system problems later in life, possibly du…

This study is testing a special type of MRI scan to see if it can help doctors predict which patients with kidney disease are most likely to develop serious heart problems. Researchers will scan the hearts and kidneys of 120 people with different kidney conditions, including rece…

This Scottish study follows 200 kidney transplant patients to see if certain substances in their urine can predict transplant rejection. Researchers will collect urine samples during routine check-ups to identify early warning signs. The goal is to find better ways to monitor tra…

This study aims to understand how kidney transplant affects heart health in people with advanced kidney disease. Researchers will measure heart blood flow and function in 80 patients before and after transplant to see if improved kidney function reduces inflammation and helps the…