KIDNEY TRANSPLANT

This study tests a drug called sparsentan in 20 adults who have had a kidney transplant and still have protein in their urine due to IgA nephropathy or FSGS. The goal is to see if the drug can safely reduce protein levels over 36 weeks. Participants take one pill daily, and the s…

This study tests whether injecting Berinert (C1 esterase inhibitor) directly into a deceased donor kidney before transplant can improve kidney function one year later. About 180 adults on dialysis awaiting a kidney transplant will receive either the drug or a placebo. The goal is…

This study tests the safety of a special jacket that keeps donated kidneys warm during transplant surgery. About 20 adult kidney transplant recipients will use the device. The main goal is to see if the jacket causes any serious side effects within 30 days after the operation.

This study is testing whether a single or repeated infusion of donor stem cells is safe for people with chronic kidney disease, including those who have had a kidney transplant. The stem cells are taken from bone marrow and given through a vein or directly into the kidney arterie…

This study involves 800 adult first-time kidney transplant recipients. Researchers will use a blood test (molecular mismatch score) to identify those at higher risk for rejection. Six months after transplant, 300 eligible participants will be randomly assigned to switch from tacr…

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This study is testing whether empagliflozin, a drug used for diabetes and kidney disease, is safe for people who have received a kidney transplant. The goal is to see if it can help protect the transplanted kidney and heart from long-term damage. The study will enroll 264 veteran…

This study tests whether adding sodium thiosulfate to the fluid that keeps donated kidneys cold during transport can reduce damage and improve function after transplant. About 120 adults receiving a deceased-donor kidney will be randomly assigned to get the additive or standard c…

This study tests if the drug ravulizumab can help transplanted kidneys start working sooner, reducing the need for dialysis. It involves 450 adults at high risk for delayed graft function after receiving a deceased donor kidney. Participants will receive either ravulizumab or a p…

This study compares two drug combinations for children aged 13-20 who receive a kidney transplant. One group gets belatacept and sirolimus, the other gets standard drugs tacrolimus and MMF. The goal is to see which combo better prevents organ rejection and keeps the kidney workin…

This early-stage study tests whether injecting donor stem cells directly into the artery of a transplanted kidney is safe and can reduce inflammation from rejection. It involves 12 adult kidney transplant recipients who have signs of rejection on biopsy. The goal is to see if thi…

This phase 3 study tests VX-880, a cell therapy, in 10 adults with type 1 diabetes who have already received a kidney transplant. The main goal is to see if participants can stop taking insulin while staying on lifelong anti-rejection drugs. The study will measure insulin indepen…

This study tests a new approach to help kidney transplant recipients accept their new organ without needing lifelong anti-rejection medication. Participants receive a special combination of radiation and a drug, followed by a stem cell infusion from the same sibling who donated t…

This study tests a new drug, leymovir, against the standard drug valganciclovir for preventing cytomegalovirus (CMV) infection in 290 Chinese kidney transplant recipients. Leymovir works differently and may cause fewer side effects like low white blood cell counts and kidney dama…

This study tests if a doctor-led counseling program, plus two smartphone apps, can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The main goal is…

This study is for adults who have received a kidney transplant and take the drug tacrolimus to protect their new kidney. The goal is to understand why some patients develop blood sugar problems like prediabetes or diabetes. Researchers will look at how quickly each person's body …

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers want to see if getting a new kidney improves blood flow to the heart and reduces inflammation. Participants will have heart scans and blood tests before and …

This study explores whether artificial intelligence can create personalized stories to help children aged 5-12 who have received a kidney transplant. Researchers will ask 100 children and their families to read the stories and share their experiences. The goal is to see if this a…

This study tests two new imaging methods—ultrasound and light-based scanning—to see if they can safely check the health of a kidney transplant. Ten adult kidney transplant patients who already need a biopsy will also get these non-invasive scans. If the scans work well, they migh…

This study is testing whether a special type of MRI scan, called manganese-enhanced MRI (MEMRI), can help predict heart and kidney complications in people with kidney disease. Researchers will scan 120 adults with conditions like acute kidney injury, chronic kidney disease, or ki…

This study is observing 200 kidney transplant patients in Scotland to see if certain biomarkers (biological signs) can help predict transplant rejection. Researchers will track how many patients experience rejection, confirmed by a biopsy. The goal is to improve long-term outcome…

This study collects blood samples from 400 kidney transplant patients to help develop a non-invasive test that detects donor DNA in the blood. The test aims to monitor the health of the transplanted kidney without needing a biopsy. Participants must be 18 or older, have had a kid…

This study explores a new, non-invasive MRI method to monitor kidney health after a transplant. Instead of relying on blood tests or invasive biopsies, the MRI measures blood flow and oxygen levels in the kidney. The goal is to detect problems earlier and more accurately, improvi…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study aims to understand how a patient's health changes during the first year after a kidney transplant. Researchers will observe 30 adult transplant patients, tracking their risk factors for heart disease and stroke, as well as other new health conditions. The study involve…