New drug aims to kickstart transplanted kidneys faster

NCT ID NCT06830798

Recruiting now Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether ravulizumab, given intravenously, can reduce the severity of delayed graft function (DGF) in adults at high risk after kidney transplant. DGF is when the new kidney is slow to start working, often requiring dialysis. The study will compare ravulizumab to a placebo in 450 participants, measuring time to freedom from dialysis and other outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ravulizumab

What this could lead to

If successful, this could reduce the need for dialysis after kidney transplant, helping the new kidney work sooner and improving recovery.

What could go wrong

This is an early-phase trial with 450 participants, so results may not apply to everyone. Ravulizumab can increase infection risk, and the benefit over placebo is not yet proven.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Delayed Graft Function end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELAYED GRAFT FUNCTION DGF KIDNEY TRANSPLANT

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Phoenix, Arizona, 85054, United States
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Los Angeles, California, 90095, United States
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San Francisco, California, 94115, United States
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San Francisco, California, 94143, United States
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Stanford, California, 94305, United States
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New Haven, Connecticut, 06510, United States
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Jacksonville, Florida, 32224, United States
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Tampa, Florida, 33606, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60608, United States
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Chicago, Illinois, 60637, United States
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Fairway, Kansas, 66205, United States
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Lexington, Kentucky, 40508, United States
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Kenner, Louisiana, 70065, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48202, United States
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Minneapolis, Minnesota, 55455, United States
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St Louis, Missouri, 63108, United States
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Omaha, Nebraska, 68198, United States
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Livingston, New Jersey, 07039, United States
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New York, New York, 10016, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27705, United States
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Philadelphia, Pennsylvania, 19140, United States
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Greenville, South Carolina, 29605, United States
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Nashville, Tennessee, 37232, United States
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Dallas, Texas, 75235, United States
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Houston, Texas, 77030, United States
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Charlottesville, Virginia, 22908, United States
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Richmond, Virginia, 23298, United States
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Seattle, Washington, 98104, United States
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Milwaukee, Wisconsin, 53226, United States
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Buenos Aires, 1425, Argentina
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Buenos Aires, B1629AHJ, Argentina
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Buenos Aires, C1431FWO, Argentina
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Capital Federal, C1155ADP, Argentina
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Córdoba, X5016LIG, Argentina
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Adelaide, 5000, Australia
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Brisbane, 4102, Australia
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Camperdown, 2050, Australia
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Murdoch, 6150, Australia
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Innsbruck, 6020, Austria
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Vienna, 1090, Austria
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Belo Horizonte, 30130-100, Brazil
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Belo Horizonte, 30150-221, Brazil
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Botucatu, 18618-970, Brazil
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Botucatu, 18618-970, Brazil
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Campinas, 13083, Brazil
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Fortaleza, 60175295, Brazil
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Porto Alegre, 90035-903, Brazil
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Porto Alegre, 90050-170, Brazil
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Recife, 50070-550, Brazil
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Rio de Janeiro, 1033, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04036-002, Brazil
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Edmonton, Alberta, T6G 2E1, Canada
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Vancouver, British Columbia, V5Z 1M9, Canada
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Toronto, Ontario, M5B 1W8, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Guangzhou, 510080, China
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Guangzhou, 510260, China
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Guangzhou, 510280, China
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Hangzhou, 310015, China
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Hengyang, 441021, China
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Nanning, 530007, China
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Shenzhen, 518020, China
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Taiyuan, 030032, China
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Taiyuan, 030032, China
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Tianjin, 300192, China
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Zhengzhou, 450003, China
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Hradec Kralova, 50005, Czechia
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Ostrava, 708 52, Czechia
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Prague, 140 21, Czechia
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Créteil, 94000, France
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La Rochelle, 17019, France
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La Tronche, 38700, France
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Montpellier, 34295, France
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Nantes, 44093, France
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Paris, 75651, France
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Toulouse, 31059, France
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Berlin, 10117, Germany
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Erlangen, 91054, Germany
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Lübeck, 23538, Germany
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Mainz Am Rhein, 55131, Germany
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Münster, 48149, Germany
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Bologna, 40138, Italy
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Milan, 20122, Italy
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Milan, 20162, Italy
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Padova, 35128, Italy
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Parma, 43100, Italy
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Torino, 10126, Italy
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Kyoto, 602-8566, Japan
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Suita-shi, 565-0871, Japan
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Bydgoszcz, 85-094, Poland
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Gdansk, 80-214, Poland
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Poznan, 60-355, Poland
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Warsaw, 02-091, Poland
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Lisbon, 1069-166, Portugal
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Lisbon, 1499-005, Portugal
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Lisbon, 1649-035, Portugal
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Porto, 4050-313, Portugal
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Porto, 4200319, Portugal
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Gyeonggi-do, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Badajoz, 06080, Spain
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Barakaldo, 48903, Spain
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Barcelona, 08025, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, 08907, Spain
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Barcelona, 8003, Spain
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Cadiz, 11009, Spain
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Córdoba, 14004, Spain
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Granada, 18014, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Valencia, 46009, Spain
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Valencia, 46017, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 833, Taiwan
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Taichung, 40447, Taiwan
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Taipei, 110, Taiwan
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Taoyuan, 333, Taiwan
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Leeds, LS9 7TF, United Kingdom
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London, E1 1BB, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE1 9RT, United Kingdom
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Woodville South, 5011, United Kingdom