Could the choice of anesthesia quiet the Body's surgical stress response?

This trial asks whether the type of anesthesia used during kidney donation surgery influences the body's inflammatory response at a genetic level. Healthy living kidney donors will be randomly assigned to receive either propofol (intravenous) or sevoflurane (inhaled) for general anesthesia. Researchers will measure levels of three specific microRNAs—molecules that help regulate inflammation—in blood samples taken before, right after, and 24 hours after surgery. The goal is to see if one anesthesia method is associated with a more controlled inflammatory response, which could inform safer anesthesia practices for donors and potentially improve kidney quality for transplant.