Lifestyle coaching after kidney transplant may curb weight gain and diabetes risk
NCT ID NCT06640179
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether a lifestyle program focused on diet and physical activity can help prevent weight gain and blood sugar issues in adults who have recently had a kidney transplant. About 60 participants will either receive standard medical care alone or standard care plus weekly behavioral sessions for 6 months. Researchers will check if the program is feasible and if it leads to better weight control, body composition, and glucose metabolism compared to standard care alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- lifestyle intervention (diet and physical activity counseling)
- What this could lead to
- If successful, this approach could help kidney transplant patients avoid weight gain and related health issues like diabetes.
- What could go wrong
- This is a small pilot study, so results may not apply to all patients. The lifestyle program requires commitment and may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2024
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Receiving a kidney transplant within the prior 3-5 months, with the transplant received from a deceased donor or living donor. NOTE: The patient will be eligible for randomization at 3 months following the kidney transplant, or at a subsequent time once clearance from the kidney transplant physician is given, provided that the time does not exceed 5 months following the kidney transplant. * Both males and females of all race/ethnic groups are eligible for participation in this study. * \>=18 years of age. * Body mass index (BMI) \>22 kg/m2. There is no maximal BMI provided that the weight does not exceed the weight allowance of the dual-energy x-ray absorptiometer (DXA) that is used to assess body composition (maximal weight for the DXA is 350 pounds). * Ability to provide informed consent prior to participation in this study. * Ability to provide clearance from their kidney transplant physician to engage in the diet and physical activity components of the proposed intervention and to safely complete the proposed outcome measures. * Ability to walk for exercise. Exclusion Criteria: * Females who are pregnant, breastfeeding, or reporting a planned pregnancy during the study period. Female participants of childbearing age who are not currently taking contraceptive medication, are not post-menopausal, or have not been surgically sterilized will need to agree to use a double barrier method of contraception. * History of bariatric surgery. * Currently prescribed an anti-obesity medication. * Report current medical condition or treatment for a medical condition that could affect body weight. These may include the following: diabetes mellitus; hyperthyroidism; inadequately controlled hypothyroidism; chronic liver disease; cancer; gastrointestinal disorders including ulcerative colitis, Crohn's disease, or malabsorption syndromes; etc. * Current congestive heart failure, angina, uncontrolled arrhythmia, symptoms indicative of an increased acute risk for a cardiovascular event, prior myocardial infarction, coronary artery bypass grafting or angioplasty, conditions requiring chronic anticoagulation (i.e., recent or recurrent DVT). * Resting systolic blood pressure of \>=160 mmHg or resting diastolic blood pressure of \>=100 mmHg or not on a stable medical treatment to control hypertension (stable dose is defined as the same dose and type of medication for a period of at least 6 months). * Eating disorders that would contraindicate modifying eating or physical activity behaviors. * Alcohol or substance abuse. * Currently treated for psychological issues (i.e., depression, bipolar disorder, etc.) that is accompanied by the following: 1) not on a stable dose of medications for treatment within the previous 12 months, or 2) hospitalized for depression within the previous 5 years. * Report plans to relocate to a location not accessible to the study site or having employment, personal, or travel commitments that prohibit attendance at scheduled intervention sessions or assessments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can digital tools and training help more kidney patients get transplants?
- Can a new preservation fluid keep donor kidneys healthier for transplant?
- Oxygen bath for donor kidneys: a new hope for transplant success?
- Can smarter monitoring of transplant drugs prevent rejection in kids?
- Could the choice of anesthesia quiet the Body's surgical stress response?