Can smarter monitoring of transplant drugs prevent rejection in kids?
NCT ID NCT07769567
First seen Aug 18, 2026 · Last updated Aug 20, 2026 · Updated 2 times
Summary
This observational study aims to understand how daily factors like food intake and medication adherence affect the levels of immunosuppressant drugs (tacrolimus and mycophenolate) in children who have received a kidney transplant. By tracking drug exposure over a year, researchers hope to find ways to optimize dosing and improve outcomes. Participants will collect blood samples at home and answer questions via text messages on several days throughout the year.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- tacrolimus and mycophenolate (immunosuppressant drugs)
- What this could lead to
- If successful, this could lead to more personalized and effective dosing of immunosuppressants in pediatric kidney transplant recipients, potentially improving graft survival and reducing side effects.
- What could go wrong
- This is a small observational study, so findings may not apply to all patients. It does not test a new treatment, and the results depend on accurate self-collection of blood samples and adherence to the study protocol.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 25 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Cincinnati Children's Hospital
- Ages
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1 year and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Recipient of a solid organ transplant and at least 1 year of age * Receiving tacrolimus and/or mycophenolate * Patient and/or caregiver is willing to receive text notifications and has a mobile device capable of receiving and sending text and multimedia messages. * Ability to understand and willingness to sign a written informed consent * Ability to understand, read, and speak English. Exclusion Criteria: * History of allergy to tape adhesives
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can digital tools and training help more kidney patients get transplants?
- Can a new preservation fluid keep donor kidneys healthier for transplant?
- Oxygen bath for donor kidneys: a new hope for transplant success?
- Could the choice of anesthesia quiet the Body's surgical stress response?
- A simple blood test could spot kidney transplant rejection early