Can a diabetes drug protect transplanted kidneys? new study aims to find out

NCT ID NCT06013865

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function. If safe, it could help prevent heart and kidney problems in transplant recipients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: empagliflozin (Jardiance)
What this could lead to: If successful, this could show that empagliflozin is safe for kidney transplant patients, potentially reducing heart and kidney complications.
What could go wrong: This is a small, early-phase safety study, so results may not confirm effectiveness. There are concerns about increased infections and effects on graft function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome diabetes mellitus kidney failure proteinuria Rejection, Psychology

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE KIDNEY TRANSPLANT

Contacts and locations

Locations

Edward Hines Jr. VA Hospital, Hines, IL
RECRUITING

Hines, Illinois, 60141-3030, United States
Iowa City VA Health Care System, Iowa City, IA
RECRUITING

Iowa City, Iowa, 52246-2292, United States
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
RECRUITING

Omaha, Nebraska, 68105-1850, United States
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
RECRUITING

Nashville, Tennessee, 37212-2637, United States
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
RECRUITING

Pittsburgh, Pennsylvania, 15240, United States

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