Could a drug switch save transplanted kidneys?
NCT ID NCT05917522
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether switching kidney transplant patients from a standard drug (tacrolimus) to abatacept can improve kidney function and quality of life. It involves 800 participants, with 300 randomly assigned to either the new drug or standard care. The goal is to see if the switch leads to better outcomes without increasing rejection risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Abatacept (Orencia)
What this could lead to
If successful, this could offer a way to improve long-term kidney function and reduce side effects for transplant recipients.
What could go wrong
This is a Phase 2 trial, so results are still uncertain. The switch may not work for everyone and could increase the risk of rejection.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for KIDNEY TRANSPLANT are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Cedars Sinai Medical Center: Transplantation
RECRUITINGLos Angeles, California, 90048, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Cleveland Clinic Foundation: Transplantation
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
Contact
-
Duke University Medical Center: Transplantation
RECRUITINGDurham, North Carolina, 27710, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Johns Hopkins Hospital:Transplantation
RECRUITINGBaltimore, Maryland, 21287, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Massachusetts General Hospital: Transplantation
RECRUITINGBoston, Massachusetts, 02114, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Mayo Clinic Rochester: Transplantation
RECRUITINGRochester, Minnesota, 55905, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Ronald Reagan UCLA Medical Center: Transplantation
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Alabama School of Medicine: Transplantation
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Nebraska Medical Center: Transplantation
RECRUITINGOmaha, Nebraska, 68198, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Pennsylvania Medical Center: Transplantation
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Pittsburgh Medical Center: Transplantation
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Virginia Health System: Transplantation
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Wisconsin School of Medicine and Public Health: Transplantation
NOT_YET_RECRUITINGMadison, Wisconsin, 53726, United States
Contact
-
Washington University School of Medicine in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Yale University, School of Medicine: Transplantation
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact