Could a drug switch save transplanted kidneys?
NCT ID NCT05917522
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether switching kidney transplant patients from a standard drug (tacrolimus) to abatacept can improve kidney function and quality of life. It involves 800 participants, with 300 randomly assigned to either the new drug or standard care. The goal is to see if the switch leads to better outcomes without increasing rejection risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Abatacept (Orencia)
- What this could lead to
- If successful, this could offer a way to improve long-term kidney function and reduce side effects for transplant recipients.
- What could go wrong
- This is a Phase 2 trial, so results are still uncertain. The switch may not work for everyone and could increase the risk of rejection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cedars Sinai Medical Center: Transplantation
RECRUITINGLos Angeles, California, 90048, United States
-
Cleveland Clinic Foundation: Transplantation
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
-
Duke University Medical Center: Transplantation
RECRUITINGDurham, North Carolina, 27710, United States
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Johns Hopkins Hospital:Transplantation
RECRUITINGBaltimore, Maryland, 21287, United States
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Massachusetts General Hospital: Transplantation
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic Rochester: Transplantation
RECRUITINGRochester, Minnesota, 55905, United States
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Ronald Reagan UCLA Medical Center: Transplantation
RECRUITINGLos Angeles, California, 90095, United States
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University of Alabama School of Medicine: Transplantation
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Nebraska Medical Center: Transplantation
RECRUITINGOmaha, Nebraska, 68198, United States
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University of Pennsylvania Medical Center: Transplantation
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center: Transplantation
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Virginia Health System: Transplantation
RECRUITINGCharlottesville, Virginia, 22908, United States
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University of Wisconsin School of Medicine and Public Health: Transplantation
NOT_YET_RECRUITINGMadison, Wisconsin, 53726, United States
-
Washington University School of Medicine in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
-
Yale University, School of Medicine: Transplantation
RECRUITINGNew Haven, Connecticut, 06519, United States
More trials for these conditions
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- Could a daily pill shield transplant patients from a common virus?