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Scientists dive deep into immune cells to unlock type 1 diabetes secrets

NCT ID NCT05139784

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in the future. Participants are not given any treatment; they simply provide samples for research.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,160 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with type 1 diabetes, other forms of diabetes or autoimmune endocrinopathies and participants undergoing surgical lymphadenectomy are recruited among patients referred to participating hospital centers. Non-diabetic participants are recruited among patient's family members and via at-large calls for healthy volunteers.

Ages

1 year and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Type 1 diabetes: type 1 diabetes, as defined by hyperglycemia and long-term insulin therapy started within 6 months from clinical onset; and/or the presence of at least one anti-islet auto-antibody. 2. Other forms of diabetes or autoimmune endocrinopathy: other forms of diabetes (e.g. type 2, ketosis-prone, familial, secondary, immunotherapy-induced diabetes); and/or other autoimmune endocrinopathies, isolated or multiple. 3. No diabetes: absence of diabetes or impaired glucose tolerance; absence of tumor, infectious or immune pathologies, or other conditions related to autoimmune or metabolic alterations that may bias the variables under study. 4. Lymphadenectomy planned in the frame of an abdominal surgery: pancreatic lymphadenectomy planned at the occasion of an abdominal surgery for the treatment of an underlying condition. Exclusion Criteria: For all participants: ongoing pregnancy; known HIV/HCV infection; absence of social security coverage; placement under judicial protection; absence of signature of the informed study consent.

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoimmune polyendocrinopathy diabetes mellitus type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 1 diabetes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    17 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP Hôpital Avicenne

    NOT_YET_RECRUITING

    Bobigny, Île-de-France Region, 93000, France

  • APHP Hôpital Bichat

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75018, France

  • APHP Hôpital Cochin - Service de Chirurgie

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75014, France

  • APHP Hôpital Cochin - Service de Diabétologie et Immunologie Clinique

    RECRUITING

    Paris, Île-de-France Region, 75014, France

  • APHP Hôpital Européen G. Pompidou

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75015, France

  • APHP Hôpital J. Verdier

    NOT_YET_RECRUITING

    Bondy, Île-de-France Region, 93140, France

  • APHP Hôpital Kremlin-Bicêtre

    NOT_YET_RECRUITING

    Le Kremlin-Bicêtre, Île-de-France Region, 94270, France

  • APHP Hôpital L. Mourier

    NOT_YET_RECRUITING

    Colombes, Île-de-France Region, 92700, France

  • APHP Hôpital Lariboisière

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75010, France

  • APHP Hôpital Pitié-Salpêtrière - Service de Chirurgie

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75013, France

  • APHP Hôpital R. Debré

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75019, France

  • APHP Hôpital Saint Antoine

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75012, France

  • Hôpital Mignot - Service de Pédiatrie

    NOT_YET_RECRUITING

    Le Chesnay, Île-de-France Region, 78150, France

  • Hôpital Mignot - Services de Diabétologie/Endocrinologie Adultes

    NOT_YET_RECRUITING

    Le Chesnay, Île-de-France Region, 78150, France

  • Hôpital Pitié-Salpêtrière - Service de Diabétologie

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75013, France

  • Hôpital René Dubos

    NOT_YET_RECRUITING

    Pontoise, Île-de-France Region, 95300, France

  • Hôpital Sud Francilien

    NOT_YET_RECRUITING

    Corbeil-Essonnes, Île-de-France Region, 91100, France

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