Magic mushroom therapy could help Burned-Out doctors find meaning again

NCT ID NCT07565909

Not yet recruiting Symptom relief Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups, receiving preparation, a single psilocybin session, and follow-up integration. The main goals are to check safety and feasibility, and to explore how well the therapy works for easing depression and restoring a sense of fulfillment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If successful, this could point toward a new way to help healthcare workers with depression and loss of meaning, using a group retreat format with psilocybin.
What could go wrong: This is an early-phase, single-arm study with no placebo group, so results may not prove effectiveness. Psilocybin can cause temporary anxiety or confusion, and the group format may not suit everyone.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DEPRESSION

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Other studies related to the condition(s) this trial covers.