ANXIETY

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Participants must have at least one risk factor for dementia, such as high blood pressure or mild memory problems. Th…

This study tests a 9-week online program designed to help families of LGBTQ+ youth of color become more supportive and accepting. Researchers will measure changes in youth depression, anxiety, drug use, and other risks. The goal is to reduce health disparities caused by family re…

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to address common barriers like cost and t…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12–17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience to prevent substance abuse, intima…

This study tests a virtual reality game designed to help children aged 10 to 16 improve how they manage their emotions. The goal is to see if playing these VR games can reduce symptoms of anxiety and depression. About 160 kids will either play the emotion-training games or relax …

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training includes online modules, live supervision, and a buddy system where new mentors learn from experienced ones. About 96 te…

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent future depression and anxiety. About 3,000 students in Swedish high schools will take part, and their results will be compared to stude…

This study explores whether reading specially designed storybooks can teach kindergarteners coping skills to prevent anxiety. About 56 children in Singapore will participate, and researchers will measure changes in coping and anxiety levels. The goal is to see if this simple, non…

This study tests whether daily, personalized music listening can help reduce anxiety and depression in people who recently had a stroke. 132 participants will either receive standard care plus 4 weeks of therapeutic music sessions, or standard care alone. The goal is to see if mu…

This study compares two different supportive programs delivered remotely to help women recover after surgery for suspected gynecological cancer. The goal is to see which program works better for reducing pain, anxiety, depression, and sleep problems. About 160 women will take par…

This study tests whether a probiotic called Clostridium butyricum can improve anxiety and depression in people with functional dyspepsia, a common stomach disorder. About 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication.…

This study tests a brief group therapy program (ACT-i) for adults with chronic insomnia who also have mild depression or anxiety. About 76 people will be randomly assigned to either the therapy or a control group. Researchers will check sleep quality, mood, and thinking before tr…

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study looks at whether a type of therapy called cognitive analytic therapy guided self-help (CAT-GSH) works as well as the standard cognitive behavioural therapy guided self-help (CBT-GSH) for people with anxiety or depression who are coming back for more help. About 100 par…

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain medication) for reducing pain and anxiety after spine surgery. About 105 adults undergoing planned spine surgery will receive one of the two medicines right after the operation.…

This study tests whether using a virtual reality headset (REALICA) can help reduce pain and anxiety in people undergoing common outpatient urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults will use the VR device during their procedure and repor…

This study looks at whether a short, guided breathing exercise called cardiac coherence can lower anxiety in people who are nervous about getting an MRI. Researchers will compare anxiety levels in 60 adults who do the exercise before their scan versus those who don't. The goal is…

This study is testing whether watching a short animated video about a nail biopsy can help people feel less anxious, understand the procedure better, and be more satisfied with their care. About 30 adults who need a nail biopsy will take part. The goal is to see if a simple educa…

This study is testing whether college students can be trained to deliver cognitive-behavioral therapy (CBT) to high school students in rural areas. The goal is to reduce symptoms of depression, anxiety, and stress in teens aged 13 to 18. The program aims to make mental health sup…

This study tests a group therapy method called I-Reconstruction to see if it helps adults with anxiety feel better. 36 people will attend 10 weekly online sessions with breathing exercises and group discussions. Researchers will compare their progress to people receiving usual ca…

This study tests whether using virtual reality (VR) can help patients feel calm before heart surgery, reducing their need for anxiety medication. About 40 adults who request medication for pre-surgery anxiety will try VR instead. The goal is to see if VR can provide comfort witho…

This study tests whether a non-invasive brain-training technique called neurofeedback can reduce anxiety in women who have had multiple pregnancy losses. Sixty-two women will either receive real or sham neurofeedback while listening to a slow pulsing tone, plus standard counselin…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in 120 women waiting for IVF treatment. Participants are split into three groups: one gets real lavender, one gets a placebo scent, and one gets no scent. The goal is to see if aroma…

This study looks at whether listening to your own choice of music can lower anxiety during hand surgery that uses only local anesthesia (you are awake). About 170 adults will be randomly assigned to hear either their preferred music or a standard relaxation track while in the ope…

This study tests a 6-week internet-based mindfulness program for adults with chronic tinnitus (ringing in the ears) who also experience distress, anxiety, or depression. Researchers will compare the program to a waitlist group and measure changes in tinnitus distress, anxiety, an…

This study tests whether a 4-week digital program that sends activity prompts can increase physical activity and reduce depression, anxiety, and stress in adults with moderate symptoms. Fifty participants will be randomly assigned to receive the prompts or just have their symptom…

This study tests a wearable device that sends gentle electrical pulses to the brain (tACS) to ease anxiety in veterans. Up to 40 veterans under age 70 with moderate-to-severe anxiety will use the device at home for 8 weeks. Researchers will check if the treatment is practical, sa…

This study tests a computer-based program (CAST) to reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and to ease the burden on their care partners. About 388 pairs (patient and care partner) will take part. The program involves two sessi…

This study looks at whether taking high doses of vitamin B6 can change brain activity and reduce symptoms of anxiety and depression. Researchers will use EEG to measure brain waves and compare a vitamin B6 group to a placebo group. The study includes 44 adults aged 18 to 40 with …

This study tests whether personalized music playlists can help adults reduce stress, anxiety, and depression. 2000 participants will either receive custom playlists or no music intervention. The goal is to see if music can be a simple, non-drug tool for improving emotional well-b…

This study looks at whether painting mandalas during chemotherapy can help reduce anxiety, nausea, and improve comfort. Researchers will ask 120 first-time chemotherapy patients to color mandalas for at least 30 minutes during their treatment. Their anxiety, nausea, and comfort l…

This study tests a virtual program called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants work with a care coordinator online to create a personalized treatment plan, with support from their doctor and a psychiatrist if needed. The goal is…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start and stay in a telehealth counseling program. About 30 adults being treated for lung cancer at Penn M…

This study tests if press needle acupuncture can lower anxiety in adults before ear surgery. 32 participants will get either real or fake needles placed a day before surgery and left in for 3 days. Researchers will measure anxiety levels and heart rate changes to see if the treat…

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study looks at whether a multimedia education program (like videos and interactive materials) can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to receive either standard instructions or the multi…

This study tests whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep quality, anxiety, depression, fatigue, and inflammation in 276 participants over 20 weeks. The goal is to see if a si…

This study tests whether natural supplements like lavender oil, PEA, and OEA can help adults with moderate stress and sleep problems. About 240 participants will take a daily capsule for 8 weeks, and researchers will compare the supplements to a placebo. The goal is to see if the…

This study tests a short, guided self-help program called Self-Help Plus for university students who are behind on at least 3 exams and feeling significant distress. About 210 students will be randomly assigned to the program or usual support. The goal is to see if the program re…

This study tests whether watching a virtual reality experience before or during radiotherapy can lower anxiety and improve satisfaction for cancer patients. About 150 adults receiving radiation at the University of Miami will be randomly assigned to different VR techniques or a s…

This study compares two treatments for people who have both psoriasis and depression or anxiety. One group gets methotrexate alone, the other gets methotrexate plus an antidepressant (escitalopram). Over 6 months, researchers will measure changes in skin severity, quality of life…

This study is testing a mobile app called MAYA that offers cognitive behavioral therapy (CBT) to help with anxiety and depression in adults who have had a stroke. Researchers want to see if the app is easy to use and acceptable to stroke survivors. Ten participants aged 40-79 wil…

This study tests whether a tonic called Feel Free® Classic can help healthy adults feel less stressed. About 165 people aged 21-55 with mild to moderate stress will take the tonic or a placebo for 29 days. Researchers will measure stress levels and how the body processes the toni…

This study looks at whether music therapy can improve mental health and social connections in university students who feel depressed, anxious, or stressed. Twenty students aged 18-40 will be randomly assigned to either music therapy sessions or non-therapeutic music listening. Re…

This study tests a 6-week group program called Emotion Focused Family Therapy (EFFT) that teaches parents advanced skills to help their child manage emotions and improve behavior. About 200 parents of children aged 7-15 with anxiety, depression, or behavior challenges will be ran…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in people with advanced cancer. About 188 participants will be randomly assigned to recei…

This study tests whether adding a short therapy focused on handling uncertainty to standard firearm safety counseling helps active-duty military members store their guns more safely. About 100 participants will attend two counseling sessions and complete daily surveys for 28 days…

This study tests an online, self-guided therapy program for current or former public safety personnel (like police, firefighters, paramedics) who struggle with depression, anxiety, or PTSD. About 164 participants across Canada will try different versions of the program to see whi…

This study tests whether a free online program from the World Health Organization, called Doing What Matters in Times of Stress, can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with high stress levels will either ge…

This study tests a new way to help teenagers in rural India with mental health issues like depression and anxiety. Instead of specialists, trained teachers will deliver the care. The goal is to see if this approach is practical and can improve teens' emotional well-being.

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep, anxiety, depression, or epilepsy. Researchers will track changes in symptoms and quality of life over 24 weeks using standard questionnaires. The goal is to understand how effect…

This study looks at whether listening to low-intensity, calming music can reduce anxiety in teenagers. Researchers will measure changes in anxiety symptoms, heart rate, and brain activity in 60 participants aged 18-25. The goal is to find a gentle, side-effect-free way to help te…

This study tests whether an 8-session group therapy program, adapted for Turkish culture, can reduce anxiety in university students. About 40 students from Bogazici University will participate. The program uses cognitive behavioral techniques to help manage anxious thoughts and f…

This study tests whether combining neurofeedback (a brain training technique) with mindfulness can lower anxiety and stress and improve grades in nursing students. About 36 students aged 18-45 will take part. The goal is to see if this approach helps them handle academic pressure…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can help adult burn survivors manage ongoing symptoms like pain, itch, anxiety, sleep problems, and fatigue. About 34 participants will try bot…

This study tests whether using a stress ball can lower pain, anxiety, and changes in heart rate and blood pressure during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one group will squeeze a str…

This study looks at whether a 15-minute Emotional Freedom Technique (EFT) session—a type of tapping therapy—can help reduce anxiety in mothers waiting for their newborn's first hearing screening. About 70 parents will be randomly assigned to either do the tapping or just wait. Th…

This study tests whether a short virtual reality (VR) hypnosis session during a coffee break can lower anxiety in nurses working day shifts. About 56 nurses will either use VR or take a regular break, and their anxiety levels will be compared. The goal is to see if VR is a practi…

This study tests a new short-term therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety and/or depression. The therapy focuses on how young people see themselves and others, aiming to be more engaging and personalized than standard treatments.…

This study tests a special group therapy program for young adults (ages 18-29) who struggle with uncertainty and anxiety. The therapy combines cognitive-behavioral techniques with ideas from ecological systems theory. Researchers will measure changes in how participants handle un…

This study tests if a four-week internet-based cognitive behavioral therapy (iCBT) program can reduce anxiety in people who struggle with MRI scans. Sixty adults who have trouble with MRIs will be randomly assigned to receive the therapy either before or after a simulated MRI ses…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, and stressed. About 68 undergraduates in Taiwan will either use the app plus standard campus care, or just standard care. The app includes daily mood tracking, week…

This study tests an online therapy program for people with both chronic insomnia and anxiety. About 98 adults will receive therapist-guided cognitive behavioral and circadian therapy or join a waitlist control group. Researchers will measure changes in anxiety symptoms, sleep qua…

This study compares music therapy using Music Care tablets to a gas mixture (EMONO) for reducing anxiety in 128 people with low back pain undergoing a CT-guided spinal injection. Participants will be randomly assigned to listen to music or inhale the gas during the procedure. The…

This study tests whether a natural herb called ashwagandha can help reduce stress, anxiety, and sleep problems in LGBTQ+ adults who face extra stress due to stigma or discrimination. About 80 adults aged 18-45 will take either ashwagandha capsules or a placebo for 8 weeks, and re…

This study tests a program called M-O-M-S to help pregnant women in areas hit by natural disasters feel less anxious and depressed. About 240 pregnant women will attend classes led by a mother-mentor to learn about emotional changes and prepare for labor. The goal is to see if th…

This study tests whether an online recovery education and support program, led by trained teen peers and support specialists, can help teens aged 15-18 who have been recently discharged from a psychiatric facility. The program includes one-on-one and small group meetings over 8 w…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. Over 6,500 participants will use either the guide (with videos and activities) or a control app with resource links. The goal is to see if the program reduces depressiv…

This study tests whether a telemedicine-delivered cognitive behavioral program (RxWell) can help patients use fewer opioid painkillers after knee or hip replacement. About 150 adults with mild to moderate anxiety or depression symptoms will be enrolled. The program aims to improv…

This study tests a personalized, noninvasive brain stimulation treatment (TMS) for people aged 18-65 with persistent symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will receive either active or sham TMS over 10 s…

This study tests whether combining foot reflexology with a cold pack before chest tube removal can lower pain and anxiety in heart surgery patients. About 108 adults who had bypass surgery will be randomly assigned to receive the combined treatment or standard care. The goal is t…

This study tests whether a short hypnosis session before a cardiac MRI can reduce anxiety and improve image quality. Researchers will compare anxious and non-anxious adults having a heart MRI. If hypnosis helps patients stay still and calm, the images may be clearer and more usef…

This study tests whether the JoyPop app can help 110 teens aged 12-17 in Canada better manage their emotions and reduce depression, anxiety, and stress while they wait for mental health services. Participants will either use the app or continue with usual care. The goal is to see…

This study looks at 680 low-income women in rural Bangladesh who have depression. It compares two approaches: depression treatment alone versus depression treatment plus help with poverty (like income support). The goal is to see if the combined approach leads to better mood, few…

This study looks at how to best combine two common therapy techniques—changing negative thoughts and practicing detached mindfulness—for people with anxiety or depression. Researchers want to find out if using them together, alone, or in a specific order works better. About 93 ad…

This study tests whether a nasal spray containing midazolam can quickly reduce sudden anxiety in adults receiving palliative care. About 36 participants will receive either a low dose, a higher dose, or a placebo spray. Researchers will measure anxiety levels before and 30 minute…

This study tests whether a fun, group-based music training program can help underprivileged children aged 8-12 who are at risk for depression and anxiety. The program uses games to teach musical instruments, aiming to build resilience and reduce emotional distress. Researchers wi…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study tests two types of internet-based therapy for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose between a therapy focused on PTSD or one that covers all three conditio…

This study tests a group mental health program for adults 55 and older who feel lonely, isolated, or have symptoms of anxiety or depression. The program is delivered by phone or video and teaches skills to handle difficult emotions. Researchers want to see if it improves well-bei…

This early-stage study is testing a generative AI chatbot called Therabot-CALM to see if it is acceptable and helpful for people who have cannabis use disorder along with anxiety or depression. Fifteen participants will use the app for four weeks and give feedback through intervi…

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be randomly …

This study tests whether an online group therapy program (cognitive behavioral therapy) can improve depression, anxiety, and other mental health symptoms in people with cystic fibrosis and their caregivers. About 52 participants will be randomly assigned to therapy or a control g…

This study compares two types of exposure training for people with spider phobia: in-person exposure with a real spider and video-based exposure via video chat. About 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting list. Researchers me…

This study tests whether a smartphone app called JoyPop can help young adults (ages 18-25) better manage their emotions, anxiety, and depression while they wait for mental health services. About 110 participants from Northwestern Ontario will either use the app or continue with u…

This study tests a simple, drug-free technique called cutaneous resonance stimulation (RESC) to reduce anxiety in people waiting for heart surgery. About 62 participants will receive either the real RESC treatment or a sham touch. The goal is to see if RESC can calm the body's st…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment build resilience and manage stress. Participants will use the app for six sessions of skills training. The goal is to see which delivery method (video…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program is for adults on sick leave who are receiving mental health care. Participants will use an online tool that combines mental health support with work-focus…

This study is testing whether a self-guided online course that teaches dialectical behavior therapy (DBT) skills is practical and helpful for adults with mild-to-moderate depression and anxiety. About 40 participants will take the 8-week course and complete surveys to measure how…

This study tests whether a breathing technique called SKY can help college students manage stress and anxiety. About 53 students will be split into two groups: one learns SKY breathwork, the other does general yoga. Over 8 weeks, researchers will check if the program is easy to f…

This study tests whether a telehealth-based mental health program can help family members of ICU survivors cope with anxiety, depression, and PTSD. About 150 family members will use an online platform and have check-ins. The goal is to see if this approach is practical and helpfu…

This study explores whether Parent-Child Interaction Therapy (PCIT) can help parents of children aged 2-7 with behavioral issues. Researchers will measure changes in stress, anxiety, depression, and oxytocin levels through surveys and saliva samples. The goal is to see if this th…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for college and university students with mild to moderate depression or anxiety. About 200 students in Saskatchewan can choose a 5-week, 8-week, or flexible course, all with optional therapis…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which one works better for autistic adults with depression or anxiety. About 300 participants from North Carolina and Virginia will receive therapy sessions …

This study tests if a guided app called SilverCloud, which teaches cognitive behavioral therapy skills, can help high school students with depression or anxiety. About 120 teens will either use the app or get usual school counseling. Researchers will measure changes in mood and w…

This study tests a two-week smartphone program designed to help people who struggle to feel pleasure (anhedonia) and also experience depression, anxiety, or stress. Participants do three short daily exercises like savoring good moments or finding silver linings, delivered via aud…

This early-stage study is testing whether a low dose of oral ketamine can safely reduce anxiety in people with pancreatic cancer who are currently on or recently finished cancer treatment. About 20 participants will receive both ketamine and a placebo at different times to compar…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help cancer survivors who struggle with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain tumors will receive the drug in a contro…

This study tests whether watching an interactive movie before anesthesia can lower anxiety in children aged 2 to 6 who are having surgery. About 70 kids will either get the movie distraction or standard care. The goal is to see if this simple, fun tool makes the experience less s…

This study tests if a marijuana-based drug (mostly CBD with a little THC) can reduce anxiety in autistic adults. 108 people aged 18-45 will take the drug or a placebo daily for 8 weeks. Researchers will track anxiety, social skills, and repetitive behaviors through weekly check-i…

This study tests whether listening to binaural beats (special sound patterns) or your favorite music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. Fifty adults having outpatient joint replacement will be randomly assigned to one of the two sound…

This study looks at two ways to decide the best treatment for anxiety and depression in 1,000 community college students. Participants will be placed into one of three care levels: self-guided online help, coach-guided online therapy, or care from a clinician. The goal is to see …

This study tests a new group program called BEAR for women who have experienced trauma and have current suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Researchers want to see if it's possible to run the pr…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in 600 women undergoing breast biopsies. Participants will be randomly assigned to one of three groups. The goal is to see if these simple, drug-free techniques make the p…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors struggle with anxiety, depression, and PTSD, but few have access to mental health care. The app aims to help them manage these symptoms on…

This study is testing two short mind-body programs for people who survived a cardiac arrest and the family or friends who care for them. The goal is to see if these programs are practical and helpful for reducing anxiety, depression, and emotional distress. About 84 pairs (surviv…

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress in young adults aged 18 to 25. Researchers will also measure memory, thinking skills, and a brain-related protein called BDNF. A total of 135 university students will be randomly a…

This study compares two ways to help children aged 5 to 7 feel less anxious during a dental numbing shot. One group gets the standard 'tell-show-do' explanation from the dentist, while the other watches a short AI-generated avatar video that explains the procedure in a fun, kid-f…

This study tests whether an online therapy program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. About 30 children and their parent…

This study tests whether letting young children (ages 3 to 5.5) watch a 3-minute virtual reality video of the clinic before their checkup can reduce their fear and stress. Half the kids will use VR goggles to see a 360° tour of the exam room, while the other half wait as usual. R…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general education group. Researchers will compare cha…

This study looks at how memory, focus, and other thinking skills relate to work performance and sick leave in people with depression or anxiety. Researchers will give metacognitive therapy combined with work-focused support to 200 adults at risk of sick leave. The goal is to see …

This study looks at whether showing children a short animated video of the pin removal procedure can reduce their pain and anxiety. About 120 children aged 4 to 12 who had surgery for a broken elbow will be randomly assigned to watch the video or receive standard care. Researcher…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty participants with a life expectancy of 12 weeks to 2 years will receive either two doses of LSD or a very low dose as a placebo.…

This study looks at whether doing progressive relaxation exercises with a therapeutic clown can help lower fear, anxiety, and stress in children aged 6-10 before they have circumcision surgery. The children are split into three groups: one does relaxation with a clown, one with a…

This study tests whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in adults undergoing a medical procedure called ERCP. About 70 participants will be randomly assigned to either receive standard care plus box breathing training o…

This study looks at whether watching a short AI-generated story video at home can reduce fear and anxiety in children aged 4 to 10 before their first skin prick test for allergies or asthma. About 100 children will be randomly assigned to either watch the video or receive standar…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds a care manager to usual neurology visits to support emotional well-being. The goal is to see if this approach improves quality of life more than…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help adult children of genocide survivors who suffer from depression or anxiety. One hundred participants will receive the treatment in a controlled setting. The goal is to se…

This study compares two breathing techniques (cyclic sighing and box breathing) with hypnosis and listening to an audiobook about stress. Researchers want to see if these practices can lower anxiety right away and after four weeks of daily use. About 80 adults will participate, a…

This study tests whether giving a low dose of midazolam (a sedative) during surgery can lower the risk of confusion (delirium) and anxiety in older adults after their operation. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to receive…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study looks at whether listening to music for 10 minutes during labor can lower anxiety and pain levels for women giving birth. About 106 participants will either listen to music or have no music, then answer questions about their anxiety, pain, and satisfaction. The goal is…

This study tests whether adding extra lessons on loneliness to an online therapy program (the Wellbeing Course) helps people with depression and anxiety feel better. About 494 adults from Saskatchewan who often feel lonely will take part. Over 8 weeks, they will complete online l…

This study tests if text messages can help people with Generalized Anxiety Disorder worry less. Researchers will compare a text-based program that helps people stop worry-related habits to a relaxation technique. The goal is to see if this simple, low-cost approach can ease anxie…

This study tests whether a nutritional drink called 'Think Tank' can help middle-aged women (40-60 years old) think more clearly after experiencing stress. Forty healthy women who drink caffeine daily will take either the drink or a placebo and then complete thinking and memory t…

This study tests a 10-week online group program for adults with spina bifida to improve self-esteem, quality of life, and reduce anxiety and depression. Participants attend weekly 1.5-hour video sessions with 6-7 others, plus two follow-ups. The goal is to strengthen social skill…

This study tests a mental health support program for 150 people who recently left the ICU. The program includes digital tools, coaching, and psychiatric help to reduce anxiety, depression, and PTSD symptoms. Participants are compared to those receiving usual care over six months.

This study tests a free, online single-session therapy for teens aged 12-17 in Hong Kong who are waiting for in-person psychotherapy. The goal is to quickly reduce symptoms of anxiety and depression, and make teens feel more ready for future treatment. About 124 participants will…

This early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will take a pharmaceutical-grade psilocybin pill and take part in guided discussions. The go…

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and better cope with stress. Sixty adults on maintenance hemodialysis will use personalized relaxation techniques guided by AI during their sessions. Researchers will me…

This study tests whether a group-based therapy called Acceptance and Commitment Therapy (ACT) helps university students with anxiety and depression more than a general support group. About 48 students aged 18-28 with moderate symptoms will join. The goal is to see if ACT improves…

This study tests a simple, 3-session writing program to help sexual minority veterans cope with stress related to their identity and reduce symptoms of depression and anxiety. About 85 veterans who identify as gay, lesbian, bisexual, or queer and have significant distress will pa…

This study tests an online sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers want to see if it works and if people find it helpful. About 56 adults in Saskatchewan will take part…

This study tests if a non-invasive brain stimulation technique called rTMS can improve heart rate regulation in women who have had multiple pregnancy losses and also suffer from anxiety. 46 women will receive either real or fake (sham) stimulation in a single session. Researchers…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study tests whether using a virtual reality (VR) headset with a guided meditation program during a vasectomy can lower pain, anxiety, and discomfort. About 90 adult men will be randomly assigned to either use VR or receive standard care. The goal is to see if VR can make the…

This study looks at whether watching animated films or reading storybooks can lower fear and anxiety in children ages 7 to 12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and researchers will measure their anxiety and fear levels using spec…

This study tests an online program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program offers personalized online modules and optional video or phone calls with a therapist over 6-12 weeks. The goal is to see if the program is …

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in adolescent refugees aged 14 to 18. About 80 participants will be randomly assigned to either the START NOW program or standard care. The goal is to see if t…

This study tests a 4-week heart rate variability biofeedback program to help young ethnic minority adults (ages 18-35) with a family history of heart disease manage stress and anxiety. Participants practice guided breathing exercises at home and attend weekly check-ins. The goal …

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will measure changes in depression, anxiety, PTSD…

This study tests whether wearing a virtual reality headset during a common kidney stone procedure (ESWL) can lower pain and anxiety. About 72 adults will be randomly assigned to either standard care or standard care plus VR. The goal is to see if VR can distract patients enough t…

This study is testing an online educational program called On-Trac for adult cancer survivors who have significant anxiety. The program teaches coping strategies based on cognitive-behavioral therapy and acceptance commitment therapy. About 80 participants will use the program at…

This study offers a free 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce symptoms of anxiety, depression, and stress while improving quality of life and healthy coping skills. Participants will complete surveys before and af…

This study tests whether a 6-week group training in nonviolent communication (NVC) can improve mental well-being in parents of primary-school children. About 172 parents with mild to severe anxiety or depression symptoms will be randomly assigned to take the training right away o…

This study tests an internet-delivered cognitive behavioral therapy course designed for new and expecting parents who struggle with anxiety or depression. Over 8 weeks, 60 participants will review online materials and complete questionnaires to track changes in symptoms. The goal…

This study tests whether buspirone, a medication used for anxiety, can help reduce withdrawal symptoms and cravings in people with opioid use disorder. About 100 adults will take buspirone or a placebo during a 10-12 day supervised detox. The goal is to see if buspirone makes the…

This study tests whether a mobile app called JoyPop can help Indigenous youth aged 18-25 in Northwestern Ontario manage their emotions and reduce stress while they wait for mental health services. Participants will either use the app or receive usual care. The goal is to see if t…

This study tests whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer who are receiving chemotherapy. 78 patients will be split into three groups: virtual art therapy…

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause). The trial will include 180 adults aged 18-80 who have mild to moderate anx…

This study tests whether using a virtual reality (VR) headset before surgery can lower anxiety, stress, and pain. About 172 adults scheduled for elective surgery will either use VR or receive standard care. Researchers will measure anxiety through questionnaires and brain activit…

This study looks at whether coloring can help adults feel less pain and anxiety while they wait in the emergency room. About 168 people with moderate pain or anxiety will be given nature or geometric coloring sheets to use. Researchers will measure changes in their self-reported …

This study looks at whether a procedure called a bilateral cervical sympathetic block (BCSB) can help reduce symptoms of PTSD, anxiety, and traumatic brain injury in Special Operations Veterans. Some participants will receive the block alone, while others will also get structured…

This study tests a mindfulness program delivered through a smartphone app for young adults aged 18-24 who have experienced early life adversity. Participants will use the app, attend weekly Zoom group sessions, and wear a Fitbit to track sleep. The goal is to see if the program i…

This study is testing a 10-week online psychological treatment program for cancer survivors who are struggling with anxiety, depression, or fear of their cancer returning. It aims to find out which parts of the therapy are most helpful. The program involves 400 survivors in Swede…

This study looks at whether cognitive remediation—a type of brain training with coaching—can improve thinking skills, daily function, and behavior in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take …

This study looks at how a park-based afterschool program affects the mental health, resilience, physical fitness, and violence prevention of 1000 teens aged 12-17 in Miami-Dade County. Researchers will measure changes in weight, blood pressure, fitness, anxiety, depression, and o…

This study is testing a new program designed to support Lakota LGBTQ2S+ youth and their caregivers. The program includes 8 weekly group sessions to improve family relationships and reduce risks like depression, anxiety, and suicide. About 28 youth and their caregivers will take p…

This study tracks 100 men aged 30-75 who had a heart procedure (stent placement) to see how their erectile function changes over 6 months. Half had a recent heart attack, half had stable chest pain. Researchers will use a standard questionnaire to compare the two groups and under…

This study looks at whether mindfulness meditation or reducing social media and replacing it with exercise can improve mental health in college students who use social media heavily. 300 students will be split into three groups: one does nothing different, one practices mindfulne…

This study tests a questionnaire to better understand anxiety in cancer patients before surgery. Researchers will ask 180 Italian-speaking adults to complete the survey, aiming to identify what causes the most worry. The goal is to help nurses provide personalized support and red…

This study tests a program called FOREST that teaches positive emotion skills to staff at a gun violence prevention agency. The goal is to reduce burnout, anxiety, and depression while improving well-being and job retention. About 100 workers will take part in the 9-month program…

This observational study aims to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function to see how these factors relate. The…

This online registry tracks pregnant women with migraines to see if a device that stimulates a nerve in the head is safe and helpful during and after pregnancy. About 550 women will fill out short surveys over 12 months, with no required changes to their current migraine treatmen…

This study follows 540 adults with solid cancers to see how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to predict who might need extra support. No new treatment is given—the goal is to learn how to better help…

This study explores whether a non-invasive device placed in the outer ear can detect brain waves (theta rhythms) linked to anxiety. Currently, measuring these signals requires surgery, but this approach could lead to a simple, wearable diagnostic tool. Healthy volunteers aged 18-…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray as part of their regular care. Researchers will track how well the drug works, who responds best, and how it affects daily life, work, and social functioning. The goal is t…

This study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression levels. The goal is to better understand brain function, not to p…

This study tests whether an online parenting program helps Filipino families in California. About 500 parents and their children (ages 8-12) will take part. Half get the program right away; the other half get standard handouts first. Researchers will check if the program improves…

This study tests a new program called Project YES+ for youth aged 15-21 living with HIV in Zambia. The program combines peer mentoring with a mental health approach endorsed by the World Health Organization to reduce stigma related to HIV, violence, and mental health. Researchers…

This study is testing a smartphone app called TrueBlue that helps monitor symptoms of depression and anxiety. It is for adults who are at least 12 weeks pregnant or up to 12 weeks after giving birth. The goal is to see if the app is safe, easy to use, and works well for tracking …

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties to test if personalized training reduces daily negative emotions…

This study aims to understand the health and well-being of university students and employees by tracking factors like loneliness, anxiety, stress, and health habits. About 363 participants will fill out surveys and may take part in interviews. No treatment or medication is involv…

This study looks at how a history of trauma or discrimination changes the way people stay alert to threats and how social support might help. About 45 adults in stable relationships will have their eye movements and pupil size measured while viewing images or waiting for a possib…

This study explores whether dream yoga practices can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will use virtual reality and home sleep technology to learn these techniques. The goal is to understand how these practices affect brain activity and d…

This study looks at whether a temporary, non-invasive brain stimulation technique called TMS can affect how healthy people respond emotionally to stress. About 55 participants will do tasks during an MRI scan, then receive both real and fake TMS on different days to compare effec…

This study looks at whether thinking about death can increase feelings of depression and anxiety in healthy adults. Researchers will ask some participants to write about their own death and others to write about dental pain, then compare their emotional responses. The goal is to …

This study looks at how women's feelings about artificial intelligence (AI) relate to their anxiety and quality of life while going through infertility treatment. About 191 women aged 18-45 who are currently receiving treatment will fill out surveys. The goal is to understand if …

This study looks at whether teaching parents to interpret ambiguous situations less negatively can reduce anxiety in their children. Researchers will enroll 300 parent-child pairs (children ages 7-12). Parents will use a smartphone app for four weeks to practice thinking in a les…

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study tests a program called FRAME that helps heart failure patients discuss mental health with their doctors and loved ones. About 7,300 adults with heart failure or at risk for it will take part in clinics across Ontario, Canada. The goal is to see if the program is practi…

This study looks at whether providing meal kits and nutrition education can improve food security, diet quality, mental health, and heart health in adults aged 40 and older with low income. About 120 participants will either receive meal kits and classes or just general nutrition…

This study looks at brain patterns linked to negative emotions in 40 adults with depression or anxiety. Researchers will use brain scans to create a personal 'negative emotion map' for each person, then test different types of magnetic stimulation (TMS) to find which one best dis…

This study is testing whether a smartphone app can help firefighters improve their sleep, thinking, and overall well-being. About 50 firefighters will use the app and report on their sleep habits. The goal is to see if the program is easy to use and helpful for this group.

This study looks at how often sexual problems occur in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. About 140 women with relapsing-remitting MS will fill out questionnaires and take simple tests. T…

This study compares two web-based apps to see which one better helps Latinas with anxiety or depression start mental health treatment. One app uses an interactive story with a character who gives treatment advice, while the other provides standard information and resources. The g…

This study aims to help families facing food insecurity and mothers with depression by providing resources like food, rent assistance, and mental health support. Researchers will enroll 2,000 caregivers of young children hospitalized at Texas Children's Hospital to see if these i…

This study interviews 30 adults who are anxious about their upcoming elective surgery. The goal is to learn what specifically worries them, since patient concerns can predict long-term pain after surgery. By understanding these fears, researchers hope to create better, personaliz…

This study looks at how having control over a virtual environment changes how people feel pain and anxiety. Twenty healthy adults will experience mild pain and anxiety in different virtual settings—some safe, some controllable, some not. The goal is to understand how the brain an…

This study looks at whether patients who are more anxious before surgery are more likely to have a sudden drop in heart rate or blood pressure (called a vasovagal event) while receiving spinal anesthesia. Researchers will measure anxiety levels in 1,500 adults and watch for these…

This study looks at whether mindfulness and meditation techniques can help mothers of premature babies in the NICU produce more breastmilk and feel less stressed. About 40 mothers will learn these techniques and researchers will measure changes in milk volume, stress hormones, an…

This study explores whether seeing a picture of a supportive person can help people with social anxiety unlearn fear more effectively. Researchers will compare the fear response of 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with images of…

This study looks at how people with anxiety or depression react to uncertain situations. Researchers will use a one-time mental exercise to see if it changes decision-making and brain activity. About 140 adults aged 25-60 who struggle with uncertainty will participate. The goal i…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered online. It aims to help adults in New York State who struggle with worry, rumination, or self-criticism. The study will track changes in attention, emotional control, and mood over 6 th…

This study looks at a telephone service called SUSTAIN that helps older adults (65+) manage depression, anxiety, or chronic pain. Researchers want to find out what factors make the program more effective and whether its benefits last over time. About 4,000 participants will be fo…

This study follows 5,000 children in a park-based afterschool program to see if it improves their physical fitness, weight, and mental health. Researchers will measure changes in body measurements, fitness tests, and questionnaires about anxiety and well-being. The goal is to und…

This study looks at how fear and anxiety about anesthesia change in people who have never had it before. About 40 adults scheduled for low-risk surgeries will fill out surveys before their procedure and answer follow-up questions a few days later. The goal is to understand their …

This study aims to see if community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to learn what works best to support mental…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will show participants either a photo of someone they trust or a stranger while they learn to associate a neutral image with a mild electric shock…

This study looks at how getting older and feeling stressed can change the way we remember and find our way around. Researchers will have 85 adults aged 65-80 do a virtual navigation task while their brains are scanned. Some will be put under mild stress to see if it makes them re…

This study aims to develop a system called CAMERA that uses signals from the brain, body, and behavior to predict anxiety and memory states. Researchers will work with 40 epilepsy patients who are already undergoing brain monitoring. The goal is to create a tool that can continuo…