ANXIETY

This study tests a program called Project YES+ for youth aged 15-21 living with HIV in Zambia. The program combines peer mentoring with mental health support to reduce stigma, violence, and depression. Researchers will enroll 400 participants to see if the program is feasible and…

This Phase 3 trial tested a once-daily extended-release capsule called centanafadine in 315 adults with both ADHD and anxiety (generalized or social anxiety). For 8 weeks, participants received either the drug or a placebo. The study measured changes in ADHD symptoms using a clin…

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) in 427 older adults from racial, ethnic, and linguistic minority groups who had depression, anxiety, and some mobility issues. The program combined mental health support with physical exercises to h…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This completed study tested a program called RISE (Resiliency in Stressful Experiences) for young men ages 18-35 leaving state prisons in Florida. The program combines trauma counseling with practical help like housing and job support. Researchers measured whether participants ha…

This study tested if transplanting healthy gut bacteria (fecal microbiota) can help people with chronic insomnia. 80 adults received either the bacteria or a placebo in capsules. Researchers measured sleep quality using sleep tests and questionnaires to see if the treatment impro…

This study tested a program called THRIVE for hospitalized people with HIV who were not regularly seeing a doctor. The program uses acceptance and commitment therapy to help patients overcome avoidance and stigma. Researchers enrolled 75 participants to see if the program was acc…

This study tested whether a speech analysis platform called AcceXible can accurately screen for depression and anxiety in university students. Over 900 students aged 16-25 provided voice samples through open-ended speaking tasks. The platform analyzed acoustic and linguistic feat…

This study tested a smartphone app that analyzes speech to screen for depression and anxiety in 785 university students aged 16-25. Participants completed speaking tasks, and the app's accuracy was compared to standard mental health questionnaires. The goal is to provide a quick,…

This study tested an online mentoring program for transgender and gender minority youth aged 14-18. The program paired each teen with an adult transgender mentor for seven 90-minute group sessions focused on building social and emotional skills. The goal was to prevent problems l…

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study tested whether a single 3-hour group therapy session based on Acceptance and Commitment Therapy (ACT) could prevent mental health disorders in 120 women recently displaced by war in Ukraine. The women had mild to moderate symptoms of anxiety or depression. The goal was…

This study tested a 12-week program called SSAGE that brings together adolescent girls, their brothers, and their parents to discuss gender roles, communication, and healthy relationships. The goal was to prevent anxiety, depression, and other mental health issues in girls who we…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This study tested whether using a stress ball during a routine fetal checkup (non-stress test) helps pregnant women feel less anxious and more comfortable. 70 pregnant women participated. The goal was to see if this simple, drug-free tool can improve the testing experience for mo…

This study tests whether a mindfulness app called Headspace can help low-income parents reduce stress, anxiety, and depression. Participants use the app on their own schedule for guided meditations. Researchers measure changes in stress and mood over time to see if the app provid…

This study tested whether using a virtual reality headset showing calming scenery for 20-30 minutes could lower anxiety in parents whose children were in the hospital. 485 parents participated, and their anxiety levels were measured and compared to standard care without any tech-…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether watching an animated educational video before a nail biopsy could reduce anxiety, improve understanding, and boost satisfaction. Thirty adults scheduled for a nail biopsy were shown the video. Researchers measured their anxiety, health literacy, and sati…

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tests whether watching virtual reality videos of mountains, beaches, and waterfalls before coronary angiography can lower anxiety, boost comfort, and improve patient satisfaction. Researchers will compare first-time angiography patients who use VR goggles to those who …

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tests whether a new dental anesthesia pen causes less pain and anxiety than a traditional syringe in children aged 6 to 12 who need a filling. Each child will try both methods (with a two-week break in between) so they can compare the experience directly. The goal is t…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tested whether a 7-minute paced breathing exercise (6 breaths per minute) could reduce anxiety and stress in 30 adults before outpatient GI procedures like colonoscopy. Participants used a noninvasive vibratory device in the waiting room. Researchers measured changes i…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study looked at whether art therapy can reduce anxiety and improve mental strength in people with chronic kidney disease who are on hemodialysis. Eighty adults who had been on dialysis for at least six months took part. The results measured changes in anxiety and psychologic…

This study tested a mobile app called EASE to help people manage anxiety and depression during the COVID-19 pandemic. It included 822 adults who identified as Black, Hispanic, or American Indian and had significant anxiety or depression symptoms. The app provided symptom tracking…

This completed trial tested whether a 4-week mindfulness program delivered via smartphone app could reduce anxiety and stress in college students. 289 students participated, practicing daily mindfulness exercises. The study measured changes in anxiety levels and perceived stress …

This study tested a virtual reality app called StoryTelling Medicine (STM) to see if it could reduce anxiety in children aged 8–13 before elective surgery. The app guides kids through hospital settings in a fun, interactive way. Researchers measured anxiety, heart rate, and stres…

This study tested whether wearing virtual reality glasses during a common kidney stone treatment (ESWL) can lower patients' pain, anxiety, and improve comfort. Seventy adults undergoing the procedure for the first time took part. Researchers measured pain, anxiety, and comfort le…

This study tested whether acupressure—a technique using gentle pressure on specific points on the body—can reduce anxiety, embarrassment, and fear in people undergoing a bladder function test called urodynamics. Sixty-eight adults were randomly assigned to receive either acupress…

This small pilot study tested whether a daily probiotic (Lactobacillus rhamnosus) could reduce abdominal pain and anxiety in children aged 9 to 13. Nine children who had both anxiety and stomach pain took the probiotic for 30 days. Researchers measured changes in pain and anxiety…

This study looked at whether motivational interviewing, a type of counseling that boosts inner motivation, can help nursing students feel less anxious and more confident about their clinical practice. 66 first-year nursing students took part in a randomized trial. The goal was to…

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study tested a 4-week music program called 'Tuned In' for 133 Hong Kong teens struggling with low mood, anxiety, or loneliness. Participants were randomly assigned to start the program right away or wait 4 weeks. The program, led by a psychologist and music therapist, aimed …

This study looked at whether using a virtual reality hypnosis headset during a frozen embryo transfer is practical and can help lower anxiety. Fifty women undergoing IVF used the headset during the procedure. The main goal was to see if the headset could be used without technical…

This study tested three short, one-time digital sessions (called Project YES) designed to help teens and young adults ages 13-25 who have depression, anxiety, or eating disorder symptoms. Participants completed questionnaires before the session, right after, and again 3 months la…

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study looked at whether painting mandalas during chemotherapy can help reduce anxiety, nausea, and improve comfort. 73 first-time chemotherapy patients took part. One group colored mandalas for at least 30 minutes during treatment, while the other group received standard car…

This study tested a program called RESET, led by community health workers, to improve physical and mental well-being in older adults. Over 450 African American adults aged 50+ with symptoms like depression, anxiety, or chronic pain took part. The program included weekly group pho…

This study tested whether squeezing a stress ball during an ultrasound-guided biopsy can reduce pain and anxiety. 79 adults were randomly assigned to either use a stress ball or receive standard care alone. Researchers measured pain, anxiety levels, and vital signs before and aft…

This study tested a brief, community-based psychological program called Problem Management Plus to see if it can reduce depression, anxiety, and distress. Over 1,200 adults with mild to moderate symptoms took part. The program focuses on practical problem-solving skills in just f…

This study tested whether an AI chatbot called Emohaa can reduce symptoms of depression, anxiety, and loneliness in young adults aged 15 to 30. 222 participants with emotional distress were randomly assigned to use the chatbot, receive traditional counseling, or join a waitlist. …

This study looked at whether different intensities of exercise can reduce anxiety in adults with anxiety disorders. 110 sedentary adults with high anxiety sensitivity were assigned to either low-intensity exercise or a program that gradually increased to high-intensity exercise o…

This study tested whether aromatherapy with essential oils can reduce anxiety in adults before elective upper limb surgery. 289 participants were randomly assigned to either receive aromatherapy or not. The goal was to see if the scent helped people feel calmer in the operating r…

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This study tested two simple, drug-free methods — squeezing a stress ball or practicing the 4-7-8 breathing technique — to help elderly patients feel less fearful and anxious before an upper GI endoscopy. 75 first-time patients were randomly assigned to one of the techniques, and…

This study tested an online psychological service called eClinic for young adults aged 15 to 35 in Hong Kong who have moderate to severe anxiety or depression. The eClinic offers a private, flexible online platform with therapist-guided self-learning modules. Researchers measured…

This study tested whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in patients undergoing a procedure called ERCP. Seventy adults were randomly assigned to either learn the breathing technique or receive standard care. The techni…

This study tested two relaxation methods—laughter yoga and emotional freedom technique (EFT, a type of tapping)—to see if they could lower anxiety in pregnant women. 120 pregnant women with high anxiety scores took part. The goal was to find simple, drug-free ways to help moms-to…

This study tested whether using a stress ball and listening to relaxing music during a colonoscopy can reduce pain and anxiety. 100 adults undergoing the procedure without sedation were split into two groups: one used the stress ball and music, the other received standard care. T…

This study tested if hand reflexology massage could reduce fatigue and anxiety in adults with end-stage kidney disease who are on maintenance hemodialysis. 70 patients were split into two groups: one received eight 21-minute hand massage sessions during dialysis over four weeks, …

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested whether using a stress ball during local anesthesia for hand surgery can lower anxiety and pain. 74 adults were randomly assigned to either squeeze a stress ball or receive standard care. Researchers measured heart rate variability and self-reported anxiety and …

This completed study tested whether giving children the drug dexmedetomidine during tonsillectomy surgery could reduce pain and agitation afterward. 85 children aged 2-10 took part. Researchers measured pain and anxiety levels after the operation to see if the drug helped compare…

This study tested whether using virtual reality before or during total knee replacement surgery could help lower anxiety and improve recovery quality. 120 adults who had the surgery participated. The results showed that VR may be a simple, drug-free way to help patients feel calm…

This study looked at whether playing music of a patient's choice during lumbar interventional procedures (like epidural steroid injections) could reduce pain and anxiety in people with chronic back pain. Thirty adults were randomly assigned to hear music or no music during their …

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study tested whether listening to nature sounds while walking after gallbladder surgery could reduce anxiety, pain, and stress. Seventy adults who had laparoscopic cholecystectomy took part. Patients walked 50 meters while hearing nature sounds, then returned to bed. Their a…

This completed study tested whether a four-week heart rate variability biofeedback program—simple paced breathing exercises—could help young ethnic minority adults (ages 18-35) with a family history of heart disease manage stress and anxiety. Participants were randomly assigned t…

This study tested three online training components for parents of anxious children aged 7-11. Parents learned to reduce accommodation, respond empathetically, or change unhelpful thoughts about their child's anxiety. The goal was to see which components, alone or combined, best l…

This study looked at whether guided breathing exercises during labor can lower stress, pain, and anxiety while improving birth satisfaction. 124 pregnant women were split into two groups: one did breathing exercises, the other received routine care. Researchers compared their exp…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested a personalized internet-based program (WebTIPS) to help children ages 1-12 feel less anxious before surgery and recover more smoothly. Over 1,200 parent-child pairs took part, with some using the tailored program and others receiving standard online information.…

This study looked at whether Acceptance and Commitment Therapy (ACT), a type of talk therapy, could help university students in Malaysia with mild to moderate anxiety, depression, and stress. 32 students either received six weekly online ACT sessions or were placed on a waiting l…

This study tested whether a 5-minute session of smelling lavender essential oil can help reduce stress, anxiety, and improve satisfaction in emergency department patients. 60 adults admitted to the ER observation unit took part. Half received a lavender-scented tube to sniff, whi…

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to fit the cultural background of Canadians of South Asian origin. Researchers worked with 146 adults who had depression or anxiety to see if this tailored therapy could help reduce their symptoms.…

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to be more culturally relevant for Chinese youth in Ontario. 36 participants aged 12 to 21 with anxiety or depression received the therapy from community therapists. The goal was to see if this app…

This study tested whether wearing colored glasses (green, red, or blue) for 10 minutes before a tooth extraction could reduce anxiety and pain. 84 adults who had not had a wisdom tooth removed before took part. Researchers measured anxiety using a standard questionnaire and check…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested a program called ENCODE designed to help family caregivers of people with dementia manage stress and communicate better about pain. 452 caregivers were randomly assigned to either the ENCODE program or friendly video calls. The goal was to see if the program imp…

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This study tested whether letting patients watch their own ACL reconstruction surgery live on a screen helps them feel less afraid of moving after the operation. 65 adults having ACL surgery under spinal anesthesia either watched the procedure or received standard care. The goal …

This study tested a brief form of cognitive behavioral therapy (bCBT) for Veterans with anxiety. 225 Veterans from three VA medical centers received either bCBT (in-person or by video) or usual care. The goal was to see if this short therapy helps reduce anxiety symptoms better t…

This study tested a school-based mental health program for teenagers with mild to moderate stress, anxiety, or depression. The program uses acceptance and commitment therapy (ACT) to help teens become more flexible and resilient. Sixty-one students took part in four group session…

This study tested a brief virtual therapy called MAPP (Mindful Adaptive Practice in Pregnancy) to help pregnant women manage COVID-19-related anxiety. 69 women participated, comparing MAPP to usual care. The goal was to see if the therapy is feasible and acceptable, not yet to pr…

This study tested a handheld device called CalmiGo in 35 adults coming to the emergency department with anxiety or panic attacks. The device uses guided breathing, aromatherapy, and grounding techniques to help people relax without medication. Researchers measured symptoms before…

This study tested whether aromatherapy with lavender and peppermint essential oils can reduce nausea and anxiety in cancer patients during chemotherapy infusions. Forty adult outpatients who reported nausea or anxiety were given a gauze with one to two drops of oil to sniff as ne…

This study tested a digital mental health app designed to help young adults (ages 18-25) who engage in nonsuicidal self-injury and are not currently in treatment. The app provides psychoeducation, skill-building exercises, and daily check-ins. Researchers compared a self-guided v…

This study tested a mindfulness-based program (including breathing exercises and meditation) in 39 Generation Z nursing students during their clinical internship. The goal was to see if it could improve mental health and reduce anxiety, depression, and stress compared to usual ca…

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This study tested a 4-week nursing program based on self-efficacy theory for 300 lung cancer patients receiving CyberKnife radiation. The program included education, psychological support, and self-management training. Researchers measured changes in anxiety, pain, and quality of…

This study tested whether a program combining behavioral activation (helping people do meaningful activities) and medication optimization (adjusting meds) can reduce depression and anxiety in adults 60 and older undergoing heart surgery. 105 participants were split into two group…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to reduce depression and anxiety in adults aged 60 and older who were scheduled for hip or knee replacement surgery. 116 participants were randomly assigned to receive the pro…

This study tested whether a gentle arm massage with sesame-lavender oil can reduce acute pain and anxiety in women after mastectomy surgery. 90 women were randomly assigned to receive massage with either sesame-lavender oil, plain sesame oil, or paraffin oil (a placebo). The goal…

This study tested a 360-degree virtual reality (VR) app to help first-year medical students prepare for their first cadaver dissection. 43 students used the VR app or traditional methods, and researchers measured their anxiety levels. The goal was to see if VR could make the expe…

This study tested whether guided breathing exercises (4-7-8 breathing and diaphragmatic breathing) can help reduce pain, anxiety, and improve comfort during the needle insertion for dialysis. 90 adults on hemodialysis were split into three groups: two doing different breathing ex…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested whether watching calming nature scenes together in virtual reality could help hospice patients and their caregivers feel better. 26 patient-caregiver pairs tried the shared VR experience. Researchers measured changes in quality of life, fear of death, and pain, …

This study tested whether using a virtual reality relaxation headset during orthodontic bonding (getting braces put on) can lower anxiety in teens and adults. 62 participants were randomly assigned to either use the VR headset or not. Researchers measured anxiety through question…

This study tested a constipation training program for mothers of children aged 4-6 with functional constipation. The program used motivational interviewing to help mothers manage their child's condition. Researchers measured changes in children's bowel movements and stool consist…

This study tested a mobile app called PCYCARE in 120 first-time pregnant women in their third trimester. The app provides educational modules and guided relaxation sessions over 21 days. Researchers measured changes in anxiety, sleep quality, and childbirth preparedness compared …

This study tested an 8-week online program to help people with multiple sclerosis (MS) improve their problem-solving and coping skills. The goal was to see if the program was easy to use and if it helped reduce anxiety and depression. Thirty adults with MS in Lebanon took part. T…

This pilot study tested whether a 12-week course of a synbiotic supplement (probiotics plus prebiotics) could help reduce anxiety in 30 children with autism spectrum disorder. The main goals were to see if the treatment was safe and tolerable, and to measure any changes in anxiet…

This study tested a 5-week online group program called Rare Group Problem Management Plus (PM+) for parents of children with rare diseases. The program teaches stress management and problem-solving skills to help reduce anxiety, depression, and distress. Eight parents participate…

This pilot study tested a wearable device that gently stimulates a nerve in the ear to help manage anxiety in teenagers with autism. Ten participants used the device at home twice daily for four weeks. The goal was to see if it was safe and easy to use, not yet to prove it works.…

This study tested whether a program that combines behavioral activation (a type of counseling that helps people engage in meaningful activities) with medication optimization (reviewing and adjusting current medications) can reduce anxiety and depression in adults aged 60 and olde…

This study tested whether a cannabidiol (CBD) solution placed under the tongue could help adults with moderate to severe anxiety. 46 participants took either full-spectrum CBD, single-compound CBD, or a placebo three times daily for four weeks, alongside their usual treatments. R…

This study tested a program where parents and children prepare together before surgery to see if it lowers children's anxiety when they get anesthesia. Fifty children aged 5 to 12 having planned surgery took part. The program involved parents being present and prepared for the op…

This study tested two brief mental strategies—reconstrual and repurposing—to see which better reduces sadness and anxiety in 233 young adults aged 18-30. Participants read an emotional story, then practiced one of the strategies and rated their feelings. The goal is to find simpl…

This study tested two simple play activities—bubble breathing and tell-show-do (a storytelling technique)—to see if they could reduce anxiety in children aged 5-12 and their parents before elective surgery. 210 families participated, and their anxiety levels were measured before …

This study tested whether wearing virtual reality glasses or listening to white noise (rain sounds) can reduce pain and anxiety during IV insertion in adults. 76 participants were randomly assigned to one of three groups: VR, white noise, or standard care. Pain and anxiety were m…

This study tested a faith-based mobile app called PRAY.COM to see if it helps university students feel better mentally and emotionally. About 450 students used the app for at least 10 minutes each day over 8 weeks. Researchers checked if students liked the app and used it regular…

This study tested whether listening to positive affirmations along with classical music during a cesarean section could lower anxiety and improve breastfeeding. 99 women were split into three groups: one listened to affirmations with music, one listened to music only, and one had…

This study tested whether acupressure—a technique using finger pressure on specific body points—can improve pain, anxiety, sleep quality, and the sense of nursing presence in intensive care patients. Sixty adults in the ICU were split into three groups: one received real acupress…

This study tested whether a trained nurse using 'hypnotic communication'—a calm, supportive way of talking—could help men feel less anxious and experience less pain during a prostate biopsy. One hundred men were randomly assigned to receive either standard care or standard care p…

This study looked at whether breathing a 50:50 mix of oxygen and nitrous oxide (laughing gas) can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, stitches, or tube placements. Researchers observed 100 children and measured their pain usi…

This study tested whether wearing a virtual reality headset showing a nature video could reduce pain and anxiety in 90 adults undergoing coronary angiography, a heart procedure where patients are awake. One group watched the VR video during the procedure, while the other received…

This study tested a mobile app that teaches Acceptance and Commitment Therapy (ACT) to help people with glaucoma cope with anxiety, depression, and emotional distress. Researchers worked with 28 patients to see if the app was acceptable and easy to use. The goal was to lay the gr…

This study tested whether using virtual reality (VR) glasses for 30 minutes each evening could improve sleep quality, reduce anxiety, and stabilize vital signs in intensive care patients with COPD. Fifty patients were split into two groups: one received VR sessions for a week, th…

This study tested whether listening to music during radionuclide treatment helps prostate cancer patients feel less anxious and distressed. Sixty men were split into two groups: one listened to their choice of instrumental music through headphones during treatment, while the othe…

This study tested whether using a virtual reality (VR) headset at home could help reduce anxiety and distress in adults with primary brain tumors. Sixty-one participants used the VR headset for 4 weeks and filled out symptom questionnaires. The goal was to see if this approach is…

This study tested whether a program called MindUP could help lower depression, anxiety, and stress in orphan teenagers in Pakistan. 61 boys aged 11-16 living in orphanages took part. Some did the MindUP program, which teaches mindfulness and emotional skills, while others did the…

This study tested whether progressive muscle relaxation (PMR) — a technique where you tense and then relax different muscle groups — could help nursing students feel less depressed, anxious, and stressed. Over 100 students were split into two groups; one group practiced PMR three…

This study tested a 6-week Integrated Attention Training Program (IATP) in 120 older adults aged 60-90 who had both anxiety symptoms and subjective memory complaints. Participants were randomly assigned to either the attention training or a health education control group. The goa…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study tested whether writing about your deepest thoughts and feelings for 15 minutes a day over two weeks can help reduce anxiety and depression in young adults. Participants were split into three groups: writing to themselves, writing to a loved one, or writing a factual da…

This study tested whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific points on the body, can lower anxiety in people recovering from foot wound surgery. Sixty adults who had surgery for a foot ulcer took part. Researchers measured their anxiety…

This study tested a group teletherapy platform called TheraGroup for Black college students dealing with anxiety and depression. Forty students took part in 12 weeks of cognitive behavioral therapy (CBT) coping skills training delivered online in a group setting. The goal was to …

This study looked at whether nature-based activities can help reduce anxiety and depression in teenagers. Researchers worked with 60 adolescents who did not have a psychiatric diagnosis. The study tested a nature therapy program and measured changes in symptoms using standard que…

This study tested whether using virtual reality (VR) during tooth extractions can lower anxiety in adults. 119 people having at least two teeth pulled under local anesthesia were randomly assigned to either use VR or not. Researchers measured anxiety before and during the procedu…

This study tested a customized mental health app called Wysa in 30 adults with chronic neck or back pain who also had anxiety or depression. The app uses an AI chatbot and human coaches to deliver therapy and mindfulness tools. Participants used the app for one month, and researc…

This study tested a daily microalgae extract (Tetrasol) in 62 healthy adults with mild stomach issues to see if it helps gut health, anxiety, and immune function. Participants took the supplement for 4 weeks, and researchers measured symptoms, stress levels, and safety through bl…

This study tested whether smelling lavender oil for a few minutes can lower anxiety in people waiting with a family member in the emergency room. 120 adults took part. Researchers measured anxiety levels before and after using a standard questionnaire. The goal is to see if a sim…

This study tested a behavioral program called IMPROVE to help college students who drink heavily and feel anxious. The program teaches skills to handle anxiety and uncertainty without turning to alcohol. Forty students took part, and researchers checked if the program was easy to…

This study tested whether listening to music with AI-generated verbal guidance that uses Eastern imagery can reduce anxiety and improve mood in Chinese university students. 123 participants were randomly assigned to music with AI guidance, standard relaxation guidance, or music a…

This study tested whether a single 60-minute session of a videogame called 'ACTing Minds' could improve mental health in 302 adults with mild to moderate depression, anxiety, or stress. The game is based on Acceptance and Commitment Therapy (ACT) and aims to increase psychologica…

This study tested whether a program inspired by Tibetan Dream Yoga—combining meditation, lucid dreaming, and virtual reality—is feasible for people with mild anxiety. Twenty-five healthy adults with good dream recall took part. The main goal was to see if people would stick with …

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study tested an 8-week text messaging program for young adults (ages 18-25) with depression or anxiety who do not want in-person therapy. Some participants got personalized messages tailored by a computer, while others got standard messages or weekly tips. The goal was to se…

This study tested whether a nature-based physical activity group was practical and helpful for university students dealing with depression and anxiety. Six students took part in group therapy sessions that included outdoor activity. Researchers measured attendance, enjoyment, and…

This study tested whether an 8-week mindfulness-based stress reduction program could lower depression, anxiety, stress, and hopelessness in parents of children with autism. 96 parents took part in weekly 60-minute group sessions. The goal is to see if this simple, non-drug approa…

This study tested whether group music therapy can improve emotional well-being, anxiety, and social connectedness in university students. 120 students in urban China were randomly assigned to active music-making, guided music listening, or a waitlist. Both therapy formats were de…

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This study tested a 10-week group program called the Sensory Awareness Program (SAP) for 207 adults with severe mental health problems and anxiety. The program teaches people to use their senses (like touch, sound, or smell) to calm anxiety without medication. Researchers compare…

This study tested whether using aromatherapy before quizzes and tests could lower test anxiety in college students. Twenty students applied essential oils (doTERRA ADAPTIV or Thinker) before exams, then measured their heart rate and blood pressure. The goal was to see if the oils…

This pilot study tested a brief cognitive behavioral therapy (CBT) program designed to help older adults (55+) safely reduce or stop their use of benzodiazepines, which are commonly prescribed for insomnia and anxiety but can be risky with age. Seventeen participants received the…

This study tested whether a guided mindfulness meditation program, practiced during dialysis sessions, could reduce anxiety and improve spiritual well-being in people with chronic kidney disease. Fifty-eight adults on hemodialysis were randomly assigned to either the meditation g…

This study tested whether letting women listen to their own chosen music during embryo transfer could lower anxiety and pain. 42 IVF patients were randomly assigned to either listen to music through noise-canceling headphones or receive standard care. Researchers measured anxiety…

This study tested whether a 45-minute chat with an AI bot could help Indian school kids (grades 6-8) feel less anxious or depressed. The bot taught a 'growth mindset'—the idea that you can improve with effort. About 383 students took part, with half getting the full chat and half…

This study looked at whether two relaxing activities—Snoezelen (a calming, multi-sensory experience) and reminiscence therapy (talking about past memories)—can help seniors feel less anxious and more positive. Researchers compared 55 older adults in Slovak care facilities who too…

This study measured anxiety in 100 patients undergoing Mohs surgery for skin cancer. Researchers compared anxiety levels between first-time and returning patients, and also tested whether reading a short story about a typical patient's experience helped reduce anxiety. The goal i…

This study tested two ways to help adults with mild anxiety and depression in primary care. One was a 10-week group program, the other a single 50-minute session. Researchers wanted to see if the shorter option worked just as well. 136 people took part, and their symptoms were tr…

This study tested whether watching a virtual reality video before abdominal surgery could reduce anxiety. 96 adult patients scheduled for elective surgery were randomly assigned to watch a VR video or a plain video. Their anxiety and stress levels were measured using a questionna…

This study looked at whether structured play activities could reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in play sessions during chemo. Anxiety levels were measured before and after play. The goal is to s…

This study tested whether wearing virtual reality glasses to visit a museum during chemotherapy could help reduce pain, fatigue, and anxiety. 64 patients were split into two groups: one received routine care, while the other also took a 20-minute virtual museum tour each week for…

This study tested two drug-free methods—deep breathing and virtual reality—to see which better reduces pain and anxiety during blood draws. 264 adults were randomly assigned to one of the two techniques or standard care. The goal is to find a simple, effective option for patients…

This study tested whether an AI voice coach called Lumen can help adults with mild-to-moderate depression or anxiety. 200 participants were randomly assigned to receive problem-solving training from Lumen, a human coach, or a waitlist. The goal was to see if the AI coach could im…

This study tested whether using virtual reality (VR) during the removal of a tube from the groin after a heart procedure could reduce pain and anxiety. One hundred adults were randomly assigned to either wear VR goggles showing calming scenes or receive standard care. Researchers…

This study tested whether a probiotic called Weizmannia coagulans BC99 can reduce symptoms of anxiety and depression in stressed adults. 79 people took either the probiotic or a placebo for 8 weeks. Researchers measured changes using standard depression and anxiety rating scales.…

This completed study tested whether a dietary supplement called Calm Active Product 1 can help reduce feelings of anxiety. 500 adults in the U.S. took either the supplement or a placebo for 6 weeks. Researchers measured changes in anxiety, stress, and sleep to see if the suppleme…

This study tested whether watching a short animated movie through a VR headset can help control the gag reflex and reduce anxiety in adults during dental X-rays. Thirty patients each had two X-rays: one with standard care and one with VR distraction. Researchers measured gagging …

This study tested a simple web-based platform called Adhere.ly to help therapists and their clients with therapy homework. 79 adults with anxiety or depression took part. The goal was to see if using the tool improved symptoms and quality of life compared to standard therapy alon…

This study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…

This study tested whether playing active or watching passive virtual reality (VR) games can change how healthy people feel heat and pressure pain. 265 adults used a VR headset in different ways, and researchers measured their pain thresholds. The goal is to see if VR could be a n…

This study looked at whether a doctor's encouraging words can help patients feel less pain and anxiety during a colonoscopy done without sedation. Over 100 adults took part, with some hearing positive phrases like "You're doing great" during the procedure. The goal was to see if …

This study tested a therapist-guided online program called AMOR for pregnant women and new mothers with ADHD. 31 participants listened to podcasts and attended online group sessions. The goal was to see if the program was easy to use and helpful for managing ADHD, stress, anxiety…

This study looked at whether doing Zumba for 10 weeks could help reduce anxiety and depression in healthy adults aged 40 to 65. Forty people were split into two groups: one did Zumba three times a week, and the other continued their normal routine. Researchers measured mood befor…

This study tested whether showing children a short movie before an endoscopy procedure can reduce their fear and anxiety and increase their satisfaction. The movie explained what would happen step-by-step. Researchers measured fear, anxiety, and satisfaction in 90 children aged 9…

This study tested whether giving midazolam, a sedative, before breast conservation surgery reduces anxiety and improves satisfaction. 124 women were randomly assigned to receive either midazolam or a placebo. Their anxiety was measured before and after the drug, and satisfaction …

This study tested whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. 70 women were randomly assigned to either use the VR headset or receive standard care. Pain and anxiety were measured right after the procedure. The goal is to find a simple…

This study tested whether adding manual acupuncture to standard anxiety treatments (medication and talk therapy) helps cancer patients feel less anxious and improves their quality of life. Thirty-eight cancer patients with moderate to severe anxiety received either real acupunctu…

This study looked at whether listening to music for a week before colon cancer surgery can lower anxiety. 116 adults scheduled for surgery were asked to listen to music three times a day. Their anxiety levels were compared to a group that did not have a music routine. The goal is…

This study tested whether letting children play digital games or watch cartoons before and during stitches can lower their pain, fear, and anxiety. 90 children aged 5-10 in the ER were split into three groups: one played games, one watched cartoons, and one received standard care…

This study tested whether learning self-hypnosis can help people with severe COPD manage anxiety and shortness of breath during pulmonary rehabilitation. 133 participants took part, with some learning hypnosis techniques in two group sessions. The goal was to see if hypnosis coul…

This study tested whether inhaling lavender essential oil can help reduce anxiety and pain in people with moderate to severe pain. 68 adults who had pain but no allergy to lavender took part. They either inhaled lavender oil or a placebo for 30 minutes, and their anxiety and pain…

This study tested whether breathing exercises and using a stress ball during dressing changes can reduce pain, anxiety, and improve comfort in burn patients. 210 adults with burns on 15% or less of their body took part. Researchers measured pain, anxiety, comfort, and vital signs…

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This 12-week study tested whether combining acupuncture, yoga, and gradual medication reduction can help adults aged 65 and older lower their use of benzodiazepines (medications for anxiety and insomnia). Twenty-three participants received weekly acupuncture, private yoga classes…

This study tested whether using a stress ball or listening to music during platelet donation can lower anxiety, stress, and pain in first-time donors. 102 donors were split into three groups: one squeezed a stress ball, one listened to instrumental music, and one received standar…

This study tested whether using virtual reality (VR) in the waiting room could reduce anxiety in 156 adults about to undergo a heart catheterization. Participants used VR while waiting for their procedure, and researchers measured their stress levels using heart rate monitors and…

This study looked at whether a simple hand massage can lower anxiety and boost comfort in people who had bariatric (weight-loss) surgery. Ninety adults took part, and researchers measured their anxiety and comfort levels after the massage. The goal was to see if this gentle touch…

This study tested whether medical hypnosis can reduce anxiety and pain in patients undergoing electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled and received either hypnosis or standard care. Researchers measured pain and anxiet…

This study tested whether qigong relaxation exercises can lower anxiety and depression in adults hospitalized for depression. 70 patients participated in a randomized controlled trial. The goal was to see if adding qigong to standard care improves mood and reduces anxiety symptom…

This study tested whether Emotional Freedom Techniques (EFT), a simple tapping therapy, can help first-time mothers feel safer, less anxious, and experience less pain after a planned cesarean section. Sixty women were split into two groups: one received EFT in the first 24 hours …

This study tested whether listening to music during wound dressing changes can help reduce pain and anxiety in people with venous leg ulcers. 97 patients were split into three groups: one listened to Turkish instrumental music, one to Western music without lyrics, and one had no …

This study examined whether virtual reality (VR) can help lower anxiety in children aged 6-15 during medical procedures. Researchers analyzed data from 168 pediatric patients who used VR as part of a quality improvement program. They measured changes in heart rate, blood pressure…

This study tested a culturally adapted internet-based cognitive behavioral therapy (iCBT) program for Arabic-speaking refugee and migrant youth aged 15–29 with mild to moderate mental health problems like depression, anxiety, and insomnia. 125 participants were randomly assigned …

This study looked at whether using virtual reality glasses or music during burn dressing changes can lower pain, anxiety, and fear of pain. 120 adults with burns on less than 15% of their body took part. Researchers measured their pain and anxiety levels using standard scales.

This completed study tested whether online mindfulness group sessions could reduce stress, anxiety, and depression in adults with type 2 diabetes. 140 people were split into two groups: one did 30-minute mindfulness exercises online, the other did not. Researchers measured change…

This study tested whether using virtual reality (VR) during an endoscopy procedure could lower patients' pain and anxiety. 78 adults who were awake during the procedure either used VR or standard care. Researchers measured pain, anxiety, and physical signs like heart rate. The go…

This study tested a 4-week movement program called Dance-Walk in 117 adults seeking mental health support. Participants either started the program right away or waited. The goal was to see if combining dance and walking could improve body awareness, energy, and reduce stress, anx…

This study looked at whether two types of talk therapy—cognitive behavioral therapy (CBT) and relaxation training—could improve mood and thinking in people with relapsing-remitting multiple sclerosis. 140 participants with mild to moderate disability were randomly assigned to one…

This study tested a program called Mood Lifters for college students. 125 undergraduates attended 14 weekly virtual meetings to learn mental health strategies. The goal was to see if this low-cost, peer-led approach could reduce symptoms of depression, anxiety, and stress. Resear…

This study tested two ways of giving numbing medicine for impacted wisdom tooth surgery in 40 healthy adults aged 18-40. One method used a computer-assisted device, the other was the standard injection. Researchers measured pain, anxiety, and vital signs like blood pressure and h…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

This study tested whether playing special music (solfeggio frequencies or Turkish classical tunes) during allergy skin tests could lower pain in children and anxiety in their parents. 120 children aged 2 to 17 took part. Parents reported their anxiety before and after the test, a…

This study looked at whether a simple home-based exercise program could help reduce anxiety and depression in people receiving hemodialysis. 54 adults on dialysis were split into two groups: one did home exercises for 6 months, the other did not. Researchers measured changes in d…

This study looked at whether music therapy can reduce pain and anxiety in people who had coronary artery bypass grafting (CABG). Sixty adults were enrolled, and those in the music group listened to music before and during surgery. Afterward, they reported their pain and anxiety l…

This study tested a program called PRISM that teaches stress management, goal-setting, and coping skills to adolescents and young adults (ages 12-24) with advanced cancer. Researchers wanted to see if it could improve quality of life and reduce anxiety and depression. The program…

This study tested whether a virtual reality (VR) experience could reduce anxiety in 75 patients scheduled for a heart valve repair procedure called TEER. Patients either got standard education or standard education plus a VR tour of the procedure and hospital. The researchers mea…

This study looked at whether listening to relaxing Turkish music for 30 minutes could help cancer patients in palliative care feel less pain and anxiety. 32 patients took part, with half listening to music and the other half resting quietly. The researchers measured pain, anxiety…

This study tested whether Emotional Freedom Techniques (EFT), a practice that involves tapping on specific body points, could reduce exam anxiety in Somali students. Sixty-two students were split into two groups: one received two EFT sessions, the other did breathing exercises. R…

This study tested two simple distraction methods—blowing bubbles and a mental game with praise—to help children aged 7 to 12 feel less pain, fear, and anxiety during a blood draw. 207 children took part, and their pain and fear levels were measured before and after the procedure.…

This study tested whether wearing virtual reality glasses during open inguinal hernia surgery with spinal anesthesia could lower anxiety and boost comfort. 84 patients were split into two groups: one watched a video using VR goggles during surgery, the other did not. Researchers …

This study tested whether using a stress ball during an elective cesarean section can reduce anxiety and pain and help with breastfeeding. 109 pregnant women participated. Half used a stress ball for 15 minutes during surgery, while the other half did not. Researchers measured an…

This study tested whether listening to relaxing instrumental music during prostate surgery helps reduce anxiety and pain afterward. 135 men having a specific type of prostate surgery were randomly assigned to either listen to music or receive standard care. Researchers measured a…

This study looked at whether coloring mandalas (circular patterns) can lower stress and anxiety in mothers whose babies are in the Neonatal Intensive Care Unit (NICU). 72 mothers took part, and researchers measured their stress and anxiety levels before and after the activity. Th…

This study looked at whether giving children stickers during an IV insertion can lower their pain and anxiety. 72 children aged 5 to 10 took part. The idea is that stickers can distract kids and make the experience less scary.

This study looked at two common methods to reduce anxiety in children aged 2-12 before an endoscopy: watching short videos or receiving a nasal spray of dexmedetomidine. Researchers measured anxiety levels at different times before the procedure. The goal was to see which approac…

This study tested whether listening to live music, hearing a ney flute, or interacting with a robotic parrot could help people on dialysis feel less anxious and less tired. 64 adults on regular hemodialysis took part. Researchers measured their anxiety and fatigue levels before, …

This study tested whether acupressure, a technique that applies gentle pressure to specific points on the body, can lower anxiety and steady vital signs in people about to have bladder removal surgery (cystectomy). Sixty adults participated, and researchers measured their anxiety…

This study looked at whether watching parrots, fish, or turtles could help reduce pain and anxiety when inserting a needle into a port catheter in 120 adults receiving palliative care. Patients were randomly assigned to one of the animal therapies, and their pain and anxiety leve…

This study tested whether visual or sensory distractions (like videos or toys) help reduce pain and anxiety in 100 healthy children aged 4-6 during a dental numbing shot. Kids were randomly assigned to a distraction group or a no-distraction group. Researchers measured pain and a…

This study tested a new type of group therapy called Terebenin's Method for adults with mild to moderate anxiety and depression. The therapy combines role-playing, body awareness, and guided discussion in weekly sessions over 8 weeks. Researchers measured changes in symptoms and …

This study tested a new web app that uses cognitive behavioral therapy (CBT) to help people with depression and anxiety. Researchers wanted to see if the app was easy to use and helpful. 50 adults from low- and middle-income countries took part. The goal was to see if this digita…

This study tested whether augmented reality glasses can reduce pain and anxiety in children during dental numbing injections. 108 children aged 7-9 were divided into four groups: some watched movies, some played video games, some did both through the glasses, and a control group …

This study tested whether showing patients a virtual tour of the surgical environment before their orthopedic surgery could lower their anxiety and boost satisfaction. 70 adults with no prior surgery experience participated. Researchers measured anxiety and satisfaction levels be…

This study looked at whether alternative treatments—external qigong, mindfulness meditation, or psychoeducation—can reduce anxiety and depression in college students. 55 students were randomly assigned to one of the three groups. Researchers measured changes in symptoms and wheth…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…

This study tested whether a short, calming virtual reality (VR) experience could reduce blood pressure and anxiety in adults with suspected white coat hypertension—where blood pressure spikes due to clinic stress. Seventy-nine participants used a VR headset for 5 minutes during a…

This study tested a short mindfulness and exposure therapy program in 13 adults with atrial fibrillation who also had high anxiety sensitivity. The goal was to see if the therapy could reduce heart-related anxiety, symptom burden, and AFib episodes. Participants attended 4-5 indi…

This study tested whether a 20-minute live classical music session (piano with or without flute) could help reduce anxiety and pain and increase relaxation in critically ill ICU patients. Researchers also looked at how patients, families, and staff felt about the music. The study…

This study tested a telephone-based therapy called Managing Anxiety from Cancer (MAC) for older adults (65+) with cancer and their caregivers. The therapy includes seven sessions covering relaxation, communication, and problem-solving skills. The goal was to see if it reduces anx…

This study tested whether a guided breathing exercise, delivered through a video or app, could help Palestinian teenagers feel less anxious and more confident. 213 teens aged 13-17 took part. The goal was to see if this simple technique could ease symptoms of anxiety and depressi…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The workshop taught coping strategies to reduce distress and improve reintegration into civilian life. 176 veterans…

This study tested whether self-acupressure on two hand points (Shenmen and Neiguan) could reduce stress, anxiety, depression, and burnout in 160 nurses. Nurses in the acupressure group pressed these points for about 2 minutes twice daily for two weeks. The study measured their sy…

This study tested whether watching 360° virtual reality movies can reduce fear and anxiety in cancer patients about to start radiation therapy. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched a VR movie and then filled …

This study tested whether a colorful undersea-themed cover for the exam table could lower fear and anxiety in children aged 3 to 12 during their first ECG. 80 children participated, with half using the special cover. The goal was to see if this simple, non-medical change could ma…

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…

This study tested whether coloring mandalas (circular patterns) could improve mood and quality of life for 51 adults hospitalized with depression and anxiety. Participants completed 8 guided coloring sessions over 3 weeks. Researchers measured changes in depression, anxiety, stre…

This study tested whether using virtual reality (VR) during the oxygen mask phase before general anesthesia could lower patient anxiety. 46 adults scheduled for surgery took part. Researchers measured anxiety levels and how easy the VR setup was to use. The goal was to see if VR …

This study tested whether having children color a ready-made picture template before circumcision reduces their anxiety and fear. Fifty children aged 5-10 were randomly assigned to either a coloring group or a control group. Researchers measured anxiety and fear using child- and …

This study adapted a 6-session behavioral therapy called FORT for Turkish breast and ovarian cancer survivors to help them manage fear of cancer recurrence. Researchers worked with 100 participants to translate and test the therapy, measuring changes in fear, anxiety, and quality…

This study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) can reduce anxiety and pain. 144 adults took part, with half listening to music and the other half receiving standard care. Researchers measured anxiety using saliva tes…

This study tested whether neurofeedback sessions can reduce anxiety and stress linked to heavy smartphone use in young adults aged 18-30. Forty participants were split into two groups: one received 25 neurofeedback sessions over 12 weeks plus an educational workshop, while the ot…

This study tested whether a brief online mindfulness program could help Indonesian university students reduce stress, anxiety, and depression. Over 400 students were randomly assigned to either the mindfulness program or a psychoeducation control group for 14 days. The goal was t…

This study tests whether shining low-level laser or LED light on specific acupoints on the hand can help people relax and improve sleep and anxiety. Researchers will measure heart rate and energy levels in 60 healthy volunteers before and after light therapy. The goal is to see i…

This study tested whether virtual reality (VR) or modified progressive muscle relaxation (MPMR) can reduce anxiety and improve attention in 158 heart patients in a cardiac care unit. Patients used VR goggles to watch calming 3D nature scenes or practiced relaxing specific muscle …

This study tested whether listening to slow-tempo music through noise-cancelling headphones twice a day could help older adults in the ICU avoid delirium—a state of confusion linked to longer hospital stays and lasting cognitive problems. Researchers enrolled 160 critically ill p…

This study tested whether using a VR headset to watch relaxing videos before surgery can lower anxiety and pain. 233 adults scheduled for elective surgery either used the VR headset or received standard care. Researchers measured anxiety levels and pain scores to see if the VR ex…

This completed study tested a one-session, nurse-led intervention called the Riddikulus Nursing Intervention to reduce anxiety in university students. 36 students with moderate anxiety were randomly assigned to receive the intervention or not. The approach helped students reframe…

This completed study tested a 16-session online therapy program for transgender and gender-diverse adults in Romania who had symptoms of depression or anxiety. The therapy was designed to address stress related to discrimination and lack of affirming healthcare, and also included…

This completed study compared the Tony Robbins Rapid Planning Method (RPM) seminar to regular journaling in 140 adults. Participants in the RPM group attended a three-day virtual seminar with mind-body exercises and motivational content, while the control group kept weekly to-do …

This study tested whether using a hand fan for 10 minutes daily over six weeks could reduce shortness of breath, anxiety, and depression in people with COPD. Fifty-nine patients from a hospital in Turkey took part, with half using the fan and half receiving standard care. The goa…

This study tested whether a vibrating device placed on the arm can distract from the pain of needle pricks. Two hundred healthy adults received different vibration patterns while having their pain threshold measured. The goal was to see if vibrations could reduce pain and anxiety…

This study tested three types of medicinal cannabis oil (with different levels of THC and CBD) against a placebo in 91 cancer patients. The goal was to see which oil, if any, helps with pain, nausea, anxiety, and sleep problems. Each patient tried multiple oils and a placebo in a…

This study looked at whether mandala painting can improve psychological well-being, emotional self-efficacy, and reduce anxiety in women with gynecologic cancer during the perioperative period. 84 patients were randomly assigned to either a mandala painting session or standard ca…

This study tested whether using a peanut-shaped ball between the knees during early labor can lower anxiety and pain in first-time mothers. 163 women were randomly assigned to use the ball or not. Researchers measured anxiety and pain levels using standard scales. The goal is to …

This study tested whether a mobile app called JoyPop can help post-secondary students aged 18-25 better manage their emotions, stress, and anxiety. 160 students were randomly assigned to use the app twice daily for 4 weeks or to receive no intervention. Researchers measured chang…

This study tested whether a 6-week group dance fitness class could lower stress and improve mood in women aged 30 to 60. Forty-six women from Louisiana State University either joined the dance classes or continued their usual routine. Researchers measured stress through saliva sa…

This study tested whether a story-based digital game played during hemodialysis sessions can help patients feel less anxious and learn more about their diet and treatment. 40 adults on regular dialysis played the game once a week for 4 weeks, each session lasting 10-15 minutes. R…

This study looked at whether showing patients a dynamic video before a prostate biopsy could lower their pain and anxiety compared to just verbal instructions or static images. 223 men aged 50-80 with elevated PSA levels participated. Pain was measured with a Visual Analog Scale …

This study tested whether daily omega-3 supplements (fish oil) can help reduce stress, anxiety, depression, and improve memory and sleep in 64 Saudi adults who reported high stress. Participants took either omega-3 or a placebo for three months. Those taking omega-3 reported lowe…

This pilot study tested the Safe and Sound Protocol (SSP), a device that plays filtered music through an app to stimulate the vagus nerve, in 45 therapy clients with PTSD and anxiety. Participants used the SSP alongside their regular therapy and completed questionnaires about the…

This study tested whether mandala coloring or group music activities could reduce future anxiety and improve well-being in 90 nursing students. Participants took part in one-hour sessions of either activity. The goal was to see if these creative approaches offer a simple way to s…

This study tested a short, skills-based anxiety treatment for veterans in primary care. 177 veterans with anxiety symptoms were randomly assigned to either the new treatment or usual care. The goal was to see if the brief therapy reduces anxiety and improves daily functioning bet…

This study tested a device called Cereset Research that plays tones in response to a person's brainwaves, aiming to reduce stress and improve sleep. 94 stressed healthcare workers used the device for several sessions and were followed for a year. The goal was to see if the device…

This study tested whether acupressure — a technique that applies pressure to specific points on the body — can reduce pain, anxiety, and stabilize heart rate and blood pressure in people undergoing urodynamics, a test that checks how well the bladder works. Sixty-eight adults wer…

This study tested whether three weekly sessions of basic disaster awareness education could improve disaster literacy and reduce earthquake anxiety in adolescents aged 10-14. A total of 128 students from two middle schools in Erzincan took part, with half receiving the education …

This study developed and tested a new questionnaire called the Excessive Emotional Behaviors Scale (EEBS) for Chinese adults experiencing anxiety or depression. Researchers interviewed 18 people and surveyed 637 participants to refine the scale, which measures behaviors like avoi…

This study compared two types of orthodontic appliances—removable braces and clear aligners—in 24 children aged 6 to 12 with crossbite. Researchers measured changes in speech, oral hygiene, pain, anxiety, and quality of life over two weeks. The goal was to understand how each app…

This study tested whether using augmented reality (AR) or a 3D hip model helps first-year nursing students learn how to give intramuscular injections better than traditional methods. 146 students were randomly assigned to practice with AR, a 3D model, or a standard model. Researc…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study surveyed 186 adults with sickle cell disease in the U.S. to learn how the COVID-19 pandemic impacted their stress, anxiety, pain, and healthcare use. Participants completed online questionnaires about their medical history, mental health, and experiences during the pan…

This completed study looked at 1,740 newly married couples to see if the bacteria in their mouth, eyes, and gut are linked to sleep problems, vision issues, and mood. Participants provided samples and completed surveys about sleep, anxiety, depression, and dry eye symptoms. The g…

This study followed nearly 10,000 Stanford undergraduates over their college years to understand how social ties, loneliness, and stress relate to anxiety and depression. Researchers used surveys and social network analysis to track changes in mental health. The goal is to create…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…

This small study tested whether a gentle brain stimulation technique called HD-tDCS could improve the effects of cognitive behavioral therapy (CBT) for people with depression, anxiety, or PTSD. Twenty participants received either real or fake stimulation daily for five weeks whil…

This study looks at whether forgiving people's medical debt can improve their mental health, reduce anxiety and depression, and help them get the medical care they need. Over 15,000 adults who owed medical debt were randomly selected to have their debt forgiven by a charity. Rese…

This completed study followed over 7,500 Chinese patients aged 65 and older who had non-cardiac surgery. Researchers measured how many developed anxiety or depression symptoms afterward using standard questionnaires. The goal was to find out how common these symptoms are and what…

This study surveyed over 750 adult patients before elective surgeries to learn about their anxiety and find out which calming methods they find helpful. Participants answered anonymous questionnaires about their feelings and preferences. The goal was to gather information to impr…

This completed study from the University of Toronto looked at whether certain gut bacteria are linked to anxiety, depression, and panic disorders. 500 adults provided stool samples to test for H. pylori and other bacteria. The goal was to understand possible root causes, not to t…

This study looked at three digital coping strategies—reappraisal, distraction, and relaxation—to help children aged 9-12 whose parents are separated or divorced. The goal was to see which tools best reduce anxiety, depression, and behavior problems. 148 children and a parent took…

This study compared Kahoot-based quizzes to traditional paper quizzes in 131 physiotherapy students over 4 weeks. Researchers measured test anxiety, stress coping, and motivation. The goal was to see if gamified learning could improve student well-being.

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study tested whether a special 4-step teaching method (called the Peyton model) helps midwifery students learn prenatal care better than standard training. 64 students were split into two groups and tested on their knowledge, skills, confidence, anxiety, and satisfaction. Th…

This study looked at whether digital services like smartphone apps can help people with psychosomatic disorders continue their treatment during the COVID-19 pandemic, when social distancing and hygiene rules limit in-person therapy. About 2000 patients from clinics took part, usi…

This study tested whether holding a newborn skin-to-skin right after a C-section (within 5 minutes) or within the first hour helps with breastfeeding, reduces anxiety, and keeps mom and baby healthy. 92 mothers and their newborns took part. The results showed that early contact c…

This study looked at whether watching short science videos can change how adults with anxiety think about psychological therapy. 262 participants watched 30 minutes of educational videos and filled out surveys about their beliefs and expectations. The goal was to understand if sc…

This study looked at 120 adults to see if anxiety and depression are linked to a common tooth infection called apical periodontitis. Participants had dental exams and filled out questionnaires about their mental health. The goal was to better understand how emotional well-being a…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This study looked at 105 adults getting a wisdom tooth removed under anesthesia. Researchers tested whether getting information verbally, through traditional materials, or from an AI source changed how anxious patients felt. The goal was to see which method helps people feel calm…

This study tested a special fiber-optic sensor that can measure breathing and heart rate during MRI scans. The goal was to see if these measurements could show how anxious a patient feels. 200 MRI patients took part, and their sensor readings were compared to anxiety questionnair…

This study tested whether an 8-week SKY breath meditation program is practical and beneficial for healthy adults. Researchers measured stress, anxiety, and happiness using surveys and wearable devices, and also looked at changes in blood markers. The goal was to see if this simpl…

This completed study looked at anxiety about COVID-19 in 200 adults with rheumatic diseases who were already taking either biologic or conventional disease-modifying drugs. Researchers called participants and asked them to fill out a questionnaire about their coronavirus-related …

This study measured anxiety levels in 543 nurses who have worked in psychiatric settings for over a year. Researchers used a standard anxiety questionnaire to understand how stress from unpredictable patients, violence risk, and emotional demands affects these healthcare workers.…

This study tested whether combining mental health treatment with job coaching helps people on sick leave due to anxiety, depression, stress, personality disorders, or functional disorders return to work. 900 participants in Denmark received either the combined service or usual ca…

This study looked at 206 medical residents in France to see if their physical activity levels are linked to anxiety, depression, and burnout. Participants filled out online surveys about their exercise habits and mental health. The goal is to understand whether staying active mig…

This study explored whether a parent's anxiety before their child's surgery influences the child's own anxiety and pain after the operation. Researchers measured anxiety in 81 parents and their children aged 2-6 undergoing groin surgery. The goal was to see if easing parental wor…

This study looked at 40 children with cerebral palsy, ages 4 to 8, to see if anxiety is linked to worse balance, muscle stiffness, and movement. Researchers measured anxiety, spasticity, balance, and gross motor function. The goal was to understand these connections better, not t…

This completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal …

This Stanford study explores how brain circuits relate to anxiety and depression. 167 participants with recent symptoms (no diagnosis needed) undergo brain scans and cognitive tests. Some also receive a 12-week course of pramipexole medication or rTMS therapy. The goal is to unde…

This study tested whether keeping a hospital diary during a child's stay in the pediatric intensive care unit (PICU) could improve mental health outcomes for families. Over 400 families participated across four PICUs in Rio de Janeiro. Researchers measured anxiety, depression, PT…

This study looked at 136 women to see if the age they entered menopause is linked to anxiety and depression. Researchers compared women with early menopause (before age 40) to those with natural menopause after 40. Participants filled out standard anxiety questionnaires during a …

This study tested whether giving cancer patients a list of questions to ask their doctors helps them feel more empowered and less anxious. About 96 patients, along with nurses and doctors, took surveys and shared their experiences. The goal is to improve communication and make pa…

This study looked at how inflammation affects feelings of pleasure and motivation in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure reward responses. The goal was to better understand the link between anxiety, inflammation, and …

This study tested whether real-time fMRI neurofeedback can help people with anxiety disorders better regulate their emotions. 21 participants practiced cognitive reappraisal while receiving feedback on their prefrontal cortex activity. The goal was to understand the brain mechani…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study looked at 103 colorectal cancer patients undergoing chemotherapy to see if anxiety and sleep problems together affect their immune cells and quality of life. Researchers measured immune markers like T-cells and asked patients about their well-being. The goal was to und…

This study looked at how a behavioral treatment called ADAPT affects brain activity in children aged 11–16 with functional abdominal pain and anxiety. The treatment combines mindfulness meditation and cognitive behavioral therapy over six sessions, delivered remotely. Researchers…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study tested whether using online tools like videos and resources on Discord could help sexual and gender minority youth (ages 14-19) seek help for depression and anxiety. 81 participants joined groups on Discord with different combinations of tools for 4 weeks. The goal was…

This study tested a mobile app designed to educate parents and caregivers of children with epilepsy. The app provides information about the condition, tracks symptoms, and helps manage appointments. Researchers wanted to see if using the app for one month would increase parents' …

This completed study tested a tablet-based screening system for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. Patients who screened positive were offered behavioral treatments like motivational interviewing and cognitive b…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This completed study at Mount Sinai measured brain waves and other body signals in 50 healthy volunteers during a standard hypnosis session. The goal was to collect data to train an artificial intelligence tool that can recognize when a person is calm or in a trance. Future resea…

This study tested two short digital videos designed to encourage COVID-19 vaccination among 1,419 adults with anxiety or depression who were not up to date on their shots. One video used 'attitudinal inoculation' to build resistance to misinformation, and the other used technique…

This study looks at how sleep influences the way children aged 10-13 remember and generalize negative experiences, which may be linked to anxiety. Researchers will use sound cues during sleep to see if they can change memory patterns. The goal is to better understand the connecti…

This study looked at how people with high anxiety process emotional faces, since they often struggle to tell safe from threatening situations. Twenty-three young adults completed brain scans and some returned months later for a computer training task that teaches them to spot tin…

This study looked at how healthy young adults (ages 18-35) suppress negative emotional memories. Researchers used EEG to track brain activity while participants performed memory-suppression tasks. The goal was to better understand the brain's natural ability to forget unpleasant …