AI chatbot aims to ease anxiety and depression in cannabis users

NCT ID NCT06920238

Completed Symptom relief Sponsor: Trustees of Dartmouth College Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and surveys. The goal is to see if the app is feasible and liked, not yet to prove it improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Therabot-CALM (a generative AI chatbot mobile app)
What this could lead to: If this works, it could point toward a new, accessible way to help people with cannabis use disorder manage anxiety and depression using a smartphone app.
What could go wrong: This is a very early, small phase 1 trial with only 15 people, focused on feasibility and usability—not on proving the app works. The app may not be effective, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder cannabis dependence Depression generalized anxiety disorder major depressive disorder mixed anxiety and depressive disorder substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY CANNABIS USE DISORDER DEPRESSION - MAJOR DEPRESSIVE DISORDER DEPRESSION, ANXIETY

Contacts and locations

Locations

46 Centerra Parkway, Suite 300, Office #333S

Lebanon, New Hampshire, 03766, United States

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