Anxiety

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination…

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training uses online modules, live coaching, and a buddy system where new mentors learn from experienced ones. About 96 teens age…

This study tests whether reading special storybooks can teach kindergarteners coping skills to prevent emotional difficulties like anxiety. About 56 children in Singapore will participate. Researchers will measure changes in coping skills and anxiety levels to see if the program …

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent depression, anxiety, and daytime sleepiness. About 3000 students in Swedish high schools will take part, and their results will be comp…

This study tests whether a virtual reality (VR) game can help children aged 10 to 16 improve their emotional regulation and reduce symptoms of anxiety and depression. Half of the 160 participants will play VR cognitive training games, while the other half will do VR relaxation ex…

This study tests a smartphone app designed to help teenagers aged 14-18 who self-harm and are not currently in therapy. The app teaches coping skills and connects them with support through a friendly chatbot. The goal is to see if the app is easy to use and helps reduce self-inju…

This study tests whether a four-session mindfulness class (Primary Care Brief Mindfulness Training) can help veterans reduce symptoms of anxiety, depression, and PTSD compared to a problem-solving class. The classes are designed for primary care settings and focus on meditation, …

This study tests whether a mobile app with short weekly exercises can help first-time parents manage emotions and reduce depression during pregnancy. About 572 expectant mothers and fathers in Singapore will use the app or receive standard care. Participants will also wear a Fitb…

This study explores whether a mobile app called FlowMD can help adults with mild anxiety. Participants use the app for 1-5 minutes of guided breathwork each day for four weeks. Surveys measure changes in anxiety levels and how easy the app is to use. The goal is to see if this ap…

This study tests a new online therapy platform called Teleo, designed specifically for children with anxiety or mood disorders. Researchers want to see if kids are more engaged during therapy sessions on Teleo compared to standard video calls. About 156 children will take part, a…

This study tests whether a videoconference with a psychologist before anterior cruciate ligament (ACL) knee surgery can reduce pain afterward. It includes 126 anxious patients scheduled for first-time ACL reconstruction. The main goal is to compare pain levels the night after sur…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This study from Stanford University tests whether two breathing techniques—cyclic sighing and box breathing—can lower anxiety, compared to hypnosis or listening to an audiobook about stress. Eighty adults will practice daily for 4 weeks and have their brain activity and heart rat…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study tests whether using a genetic test to guide antidepressant dosing helps teens aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either gene-guided dosing or standard dosing. The goal is to see if the genetic approach leads to more remi…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This study tests an internet-based cognitive behavioural therapy (ICBT) program designed specifically for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of depression, anxiety, or posttraumatic stress. Participants choose their leve…

This study tests whether a simple four-square breathing exercise done before breastfeeding can lower anxiety and improve well-being in mothers whose babies are in the neonatal intensive care unit (NICU). About 70 mothers will be split into two groups: one does the breathing exerc…

This study tests whether using virtual reality (VR) goggles during a colposcopy can lower women's anxiety, stress, and pain. About 60 women scheduled for the procedure will either receive standard care or wear a VR headset showing calming content. The goal is to see if this simpl…

This study tests whether adding poverty alleviation (like financial support) to group talk therapy helps low-income rural women in Bangladesh with depression more than therapy alone. Six hundred women aged 18-45 with depression and economic hardship will be randomly assigned to e…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This pilot study tests a mindfulness-based music breathing program for older adults (65+) with mild to moderate anxiety or depression. The goal is to see if it boosts resilience and eases symptoms like loneliness and worry. Forty participants will be randomly assigned to the prog…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study looks at whether having a therapy dog present during a dental visit can lower stress in children. About 225 kids aged 4 to 8 will be randomly assigned to have a dental exam with or without a dog. Researchers will measure stress by tracking heart rate and testing saliva…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study is testing a new type of talk therapy called Process-Based Therapy (PBT) for people with anxiety. Unlike standard treatments, PBT adapts techniques from different therapies to target each person's specific struggles. Ten adults with moderate-to-severe anxiety will try …

This study tests a web-based program called TEMPO designed to help men with prostate cancer and their caregivers cope with anxiety and improve physical activity. About 376 patient-caregiver pairs will be randomly assigned to use TEMPO or simply monitor their anxiety for 12 weeks.…

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This study tests a group therapy program called TAG TEAM for trans and gender diverse teens aged 12-17. The program helps them understand and cope with stress from discrimination and rejection. Researchers will compare the program to a waitlist to see if it reduces anxiety, depre…

This study tests if reading a personal narrative book, in addition to standard care, can help women of childbearing age manage anxiety, depression, and negative thinking before a hysterectomy. About 156 women will either receive standard information or also read a book. The goal …

This study compares group-based Acceptance and Commitment Therapy (ACT) to standard individual therapy for young people aged 16-25 with depression, anxiety, or stress. About 212 participants will be randomly assigned to either group ACT or individual therapy. The goal is to see i…

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. The program uses videos, activities, and written tips based on cognitive behavioral therapy over 7 weeks. About 6,500 participants will be randomly assigned to the prog…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will track changes in depression, anxiety, and PT…

Researchers at Yale University are testing whether a smartphone app called Caravan Wellness can improve quality of life, reduce stress, and ease symptoms of anxiety and depression. The app offers short mindfulness and light exercise modules like yoga and meditation. The study wil…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This study tests a culturally adapted cognitive-behavioral therapy (CBT) program for Venezuelan migrants in Lima, Peru, who struggle with anxiety, depression, or PTSD. The intervention is delivered remotely by trained lay providers over 6 to 12 weekly sessions. The goal is to see…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start a telehealth counseling program. About 30 adults being treated for lung cancer at Penn Medicine will…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests whether watching augmented reality (AR) health education videos can help reduce anxiety and depression in women after breast cancer surgery. 60 female patients will be randomly assigned to receive either standard education alone or standard education plus AR vide…

This study tests whether using a mindfulness app for 15 minutes a day over two weeks, plus a storytelling workshop, can improve wellbeing in STEM graduate students at the University of Wisconsin-Madison. Researchers will measure changes in depression, anxiety, stress, sleep, and …

This study tests whether a single 20-minute session of controlled breathing exercises or music therapy can calm the nervous system in people with anxiety. Researchers will measure heart rate, blood pressure, and oxygen levels in 30 healthy anxious adults. The goal is to see if th…

This study tests whether playing music during a minimally invasive heart valve replacement (TAVR) can lower patient anxiety. 100 adults scheduled for TAVR will either listen to music through headphones or wear headphones without music. Researchers will measure anxiety levels and …

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study is testing an online educational program called On-Trac to help adult cancer survivors cope with anxiety. The program teaches practical strategies based on well-known therapies like CBT and ACT. Researchers will measure changes in anxiety levels and emotional well-bein…

This study tests whether a structured emotional intelligence (EI) training program can improve mental health and reduce anxiety and depression among secondary school teachers and students in Dhaka, Bangladesh. The program teaches skills like self-awareness, self-management, socia…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and cope better with stress. About 60 adults will use personalized relaxation techniques guided by AI during their dialysis sessions. Researchers will measure changes in…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, such as depression, anxiety, or PTSD, and assign them to practi…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study is testing whether an online, self-guided dialectical behavior therapy (DBT) course is practical and helpful for adults with mild-to-moderate depression or anxiety. Up to 40 participants will take the 8-week course, which teaches skills like mindfulness and emotion reg…

This study tests an online psychological program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program offers personalized online modules and therapist calls over 6-12 weeks. Researchers want to see if patients find it acceptable…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for post-secondary students with depression or anxiety: a fast-track option, a 5-week course, and an 8-week course. About 200 students will choose their preferred option and receive optional …

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study tests whether using a virtual reality (VR) headset with a guided meditation app during a vasectomy can lower pain, anxiety, and distress. About 90 adult men will be randomly assigned to either use VR or receive standard care. They will answer short questionnaires befor…

This study looks at whether listening to music for 10 minutes during labor can lower anxiety and pain and improve satisfaction. About 106 women in labor will either listen to music or not. They will rate their anxiety and pain levels and answer questions about their care.

This Phase 2 trial tests whether adding buspirone (an anxiety medication) to lofexidine (a withdrawal drug) can reduce opioid withdrawal symptoms and cravings during detox. About 100 adults with opioid use disorder will stay in a residential setting for 10–12 days, undergo a step…

This study tests whether a tonic called Feel Free Classic can help healthy adults feel less stressed. About 165 people will take either the tonic or a placebo for 29 days. Researchers will measure stress levels and how the body processes the tonic's ingredients.

This study aims to help families with food insecurity and mothers with depression by providing resources like food, rent help, and mental health support. Researchers will enroll 2,000 caregivers of young children in the hospital to see if these services improve mother-child bondi…

This study tests whether listening to binaural beats or a patient's chosen music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. About 50 adults having these surgeries will take part. Researchers will measure pain and anxiety levels right after su…

This study tests if text messages can help people with Generalized Anxiety Disorder worry less. 300 adults with high worry levels will receive either safety-behavior fading tips via text or a relaxation exercise. The goal is to see if the text approach reduces worry and anxiety s…

This study tests whether listening to your own choice of music during awake hand surgery lowers anxiety more than standardized relaxation music. 170 adults having hand surgery with only local anesthetic will be randomly assigned to one of the two music groups. Researchers will me…

This study tests if a smartphone app called Sidekick can help teenagers with anxiety disorders practice exposure exercises between therapy sessions. About 46 teens aged 13-18 will use the app alongside their usual outpatient treatment. The goal is to see if the app is practical, …

This study tests an internet-based sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers will check if the course is easy to use and helpful for people in Saskatchewan. About 56 adul…

This study tests whether taking high-dose vitamin B6 can reduce symptoms of anxiety and depression by changing brain activity. Researchers will measure brain waves with EEG and track mood changes in 44 adults who have mild to moderate symptoms. Participants will take either vitam…

This study looks at whether a specific breathing technique called SKY breath meditation can help college students feel less stressed and anxious. About 53 students will be split into two groups: one learns the breathing method, the other does general yoga. Over 8 weeks, researche…

This study tests two types of online cognitive behavioural therapy (CBT) for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose between a therapy focused on PTSD or one that cover…

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study tests whether a daily ashwagandha supplement can lower stress, anxiety, and improve sleep in 80 LGBTQ+ adults aged 18-45 who report high stress. Participants take either ashwagandha capsules or a placebo for 8 weeks, and researchers track changes using questionnaires a…

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study tests whether adding special content about loneliness to an internet-based cognitive behavioral therapy (ICBT) program helps people with depression and anxiety feel better. About 494 adults in Saskatchewan who report feeling lonely will take part. Some will get the sta…

This study tests whether a brain-training technique called neurofeedback can help reduce anxiety in women who have had repeated pregnancy losses. Participants use a headband that monitors brain activity and plays a calming sound when the brain is in a relaxed state. The trial com…

This study tests whether a mindfulness program delivered through a smartphone app can help reduce anxiety in older adults (60+) with serious illnesses like cancer or heart disease, and their caregivers. Participants will use the app to practice mindfulness exercises. The goal is …

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in 100 adults with sarcoidosis. One group takes MBSR; the other joins a monthly virtual support group. Researchers will compare which approach …

This study tests a 7-session therapeutic song-writing program for young people aged 13 to 24 with mild to moderate depression. Participants are randomly assigned to either the song-writing program or a waitlist group. The goal is to see if the program improves depressive symptoms…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program combines mental health support with practical work-focused strategies. Researchers will enroll 400 adults in Norway who are on sick leave and receiving me…

This study tests whether natural supplements like lavender oil, PEA, and OEA can help adults with moderate stress and sleep problems. About 240 participants will take a daily capsule for 8 weeks, comparing the supplements to a placebo. The goal is to see if these natural options …

This study tests an internet-delivered cognitive behaviour therapy (ICBT) course designed specifically for public safety personnel (like police, firefighters, paramedics) who experience anxiety, depression, or PTSD. The 164 participants will be randomly assigned to different ways…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania to reduce symptoms of depression, anxiety, and stress. About 40 teens aged 13-18 with mild to moderate symptoms will participate. Th…

This study tests whether a 15-minute Emotional Freedom Technique (EFT) session—a guided acupoint tapping routine—can reduce anxiety in mothers waiting for their newborn's first hearing screening. 70 parents will be randomly assigned to either the tapping session or a standard wai…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This study looks at whether a combination of reflexology (a type of foot massage) and cold application before removing chest tubes can lower pain and anxiety in people who have had heart bypass surgery. Chest tube removal is often very painful and stressful. The researchers will …

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests whether combining a therapeutic clown with progressive relaxation exercises can reduce fear, anxiety, and stress in children aged 6-10 before circumcision surgery. 162 children will be split into three groups: one does relaxation exercises with a clown, one with …

This study tests whether a short virtual reality (VR) hypnosis session during a coffee break can lower anxiety in nurses working day shifts. Fifty-six nurses will be randomly assigned to either a VR session or a regular break, and their anxiety levels will be compared using a sta…

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This study is testing whether a structured breathing practice is a practical and acceptable option for teenagers aged 12 to 17 who have been diagnosed with anxiety or depression. The program, called Seokmun Hoheup, starts with 15-minute sessions and gradually increases to 36 minu…

This study tests whether a smartphone app called SilverCloud, which teaches cognitive behavioral therapy (CBT) skills, can help reduce anxiety and depression in high school students. About 120 teens who screen positive for symptoms will either use the app with a clinician's guida…

This study compares two group therapies for university students aged 18-28 who have moderate anxiety and depression. One group receives Acceptance and Commitment Therapy (ACT), which teaches skills to accept difficult emotions and live according to personal values. The other grou…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests whether a 5-minute mindfulness-based breathing exercise, done just before spinal anesthesia, can reduce the common drop in blood pressure and ease anxiety in women having a planned C-section. Half of the 150 participants will do slow, guided breathing (about 6 br…

This study compares two ways to calm children aged 5 to 7 before a dental numbing shot. One group gets the usual 'tell-show-do' explanation from the dentist. The other watches a short AI-generated avatar video that explains the procedure in a kid-friendly way. Researchers will me…

This study tests if a marijuana-based drug (mostly CBD with a little THC) can reduce anxiety in adults with autism. About 108 people aged 18 to 45 will take the drug or a placebo daily for 8 weeks. Researchers will track anxiety, social skills, and repetitive behaviors through we…

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This study looks at whether listening to low-intensity, calming music can reduce anxiety in teenagers and young adults aged 18 to 25. Researchers will measure changes in anxiety symptoms, heart rate, and brain activity. The goal is to find a gentle, side-effect-free way to help m…

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This study tests a nerve block procedure called bilateral cervical sympathetic block (BCSB) in 75 Special Operations Veterans with PTSD, anxiety, or traumatic brain injury. The procedure uses a numbing medicine to calm overactive nerves. Some participants also receive talk therap…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests a brief guided self-help program called Self-Help Plus for university students who are behind on at least three exams and feeling distressed. The program teaches coping skills based on acceptance and commitment therapy. Researchers will measure changes in distres…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests a group cognitive-behavioral therapy (CBT) program designed to help young adults who struggle with uncertainty. The program includes techniques like cognitive restructuring and exposure to uncertain situations, and it considers how a person's social environment a…

This study tests a special mental health program for people who have been in the ICU. It includes coaching, digital tools, and psychiatric support to help with anxiety, depression, and PTSD. The goal is to see if this program works better than usual care. About 150 adults who vis…

This pilot study tests a behavioral health program designed to support family members of ICU survivors. The program includes telehealth check-ins and a digital platform to track mood and stress. Researchers want to see if this approach is practical and helpful for reducing anxiet…

This study looks at whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer. 78 patients receiving chemotherapy will be randomly assigned to one of three groups: virtual…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face anxiety, depression, and PTSD, but mental health care is hard to access. The app aims to help them manage these symptoms on their own…

This study tests whether using virtual reality can help patients feel calm before heart surgery, reducing their need for anxiety medication. About 40 adults who request medication for pre-surgery anxiety will try VR instead. The goal is to see if VR can provide comfort without th…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This study tests whether a computer-based program can reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and also help their care partners feel less burdened. About 388 pairs (patient and care partner) will take part. The program involves …

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study tests whether giving coloring activities (nature scenes, geometric shapes, word searches, or free drawing) to adults waiting in the emergency department can lower their self-reported pain and anxiety. Researchers will measure changes using standard questionnaires. If e…

This study compares two types of exposure training for people with spider phobia: in-person exposure with a real spider and videochat-based exposure where someone else handles the spider. 72 adults with spider fear will be randomly assigned to one of these treatments or a waiting…

This study is testing whether listening to specially chosen music every day for 4 weeks can help reduce anxiety and depression in people who have recently had a stroke. About 132 participants will either receive the music therapy plus standard care, or standard care alone. The go…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study tests whether adding a one-hour cognitive behavioral session focused on handling uncertainty to standard lethal means counseling helps active-duty service members store firearms more securely. One hundred participants who own unlocked, loaded guns will attend two sessi…

This pilot study tests a new 12-week group therapy program called BEAR-SI for women aged 18-75 who have experienced interpersonal trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Th…

This study tests a simple, drug-free method called hypnotic communication to help patients feel calmer during a heart procedure (coronary angiography). About 306 adults will either receive this special calming talk from a nurse or standard care. The goal is to see if it reduces s…

This study tests whether listening to music through a special app (Music Care®) can calm anxiety as well as a gas mixture (EMONO) during a CT-guided injection for low back pain. The gas can cause nausea and dizziness, and the music app has no side effects. Researchers will compar…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether personalized music playlists can reduce stress, anxiety, and depression in adults. 2,000 participants will either receive music designed to match and gradually shift their mood, or no music. The goal is to see if this simple, non-invasive approach can imp…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teen refugees. About 80 participants aged 14-18 will be randomly assigned to either the training or standard care. The goal is to see if the program helps t…

This study tests an online, 9-week program designed to help parents and caregivers of LGBTQ+ youth of color become more supportive and accepting. Researchers will enroll 180 youth (ages 14-25) and their caregivers to see if the program reduces depression, anxiety, drug use, and o…

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness and reduce anxiety and depression. About 70 adults who have been in mental health treatment for at least 6 months will take part. …

This study looks at whether a technique that combines brain training (neurofeedback) with mindfulness can lower anxiety and stress in nursing students and improve their grades. About 36 students from the University of Salamanca will take part. The goal is to see if this approach …

This study looks at whether watching an animated film or reading a storybook can lower fear and anxiety in children aged 7 to 12 who have just been diagnosed with type 1 diabetes. About 64 children will take part, and their anxiety levels will be measured using special child-frie…

This study tests a group therapy method called I-Reconstruction to see if it lowers anxiety in adults. Thirty-six participants will attend ten weekly online sessions and complete questionnaires about their anxiety and mood. The researchers will compare them to a group receiving u…

This study tests whether press needle acupuncture can reduce anxiety in adults before ear surgery. 32 participants will get either real or sham needles placed a day before surgery. Researchers will measure anxiety levels and heart rate changes to see if the treatment works.

This study enrolls 1,000 community college students aged 18-40 who have depression or anxiety. Participants are randomly assigned to one of two decision-making methods that determine their level of care: self-guided online prevention, coach-guided online therapy, or clinician-del…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in women undergoing breast biopsies. About 600 women will be randomly assigned to one of three groups: VR, music, or usual care. Researchers will measure anxiety and pain …

This study tests whether an online parenting program, called Incredible Years, can help Filipino families in California. 500 parents and their children aged 8-12 will take part. Half will get the program, and half will receive standard handouts. The goal is to see if the program …

This study is testing whether a brief, therapist-guided expressive writing program can reduce symptoms of depression and anxiety in sexual minority veterans. Participants will complete three writing sessions focused on minority stress. The goal is to see if this approach is feasi…

This study tests a free, online single-session therapy for children and teens (ages 12-17) in Hong Kong who are waiting for in-person psychotherapy. The goal is to quickly reduce symptoms of depression and anxiety while they wait. Participants will be randomly assigned to either …

This study tests an online recovery program for teens aged 15-18 who have been discharged from a psychiatric hospital after suicidal thoughts, attempts, depression, or anxiety. The program pairs them with trained peer support specialists and teen peers for one-on-one and group me…

This study tests whether online group cognitive behavioral therapy (CBT) can reduce depression, anxiety, and other mental health symptoms in adults with cystic fibrosis and their caregivers. Participants will attend 13 sessions via Zoom and be compared to those receiving supporti…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

This study tests whether using a virtual reality headset before surgery can reduce anxiety, stress, and pain. About 172 adults having elective surgery will either use the VR headset or receive standard care. Researchers will measure anxiety through questionnaires and physical sig…

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety or depression. It compares IBTT to a well-known therapy called the Unified Protocol (CBT-based). The goal is to see if IBTT is more engaging and effectiv…

This study tests a 6-week program called Emotion Focused Family Therapy (EFFT) for parents of children aged 7-15 with anxiety, depression, or behavioral challenges. The program teaches parents how to coach their child through difficult emotions and improve their relationship. Res…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether wearing a virtual reality headset with calming scenes can reduce anxiety and stress during a cesarean section as well as a sedative drug called dexmedetomidine. Fifty-two women having planned C-sections will be randomly assigned to receive either the VR h…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 undergraduates will either use the app plus standard campus care, or just standard care alone. The app includes daily mood tracking, weekly ch…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain drug) for managing pain and anxiety after spine surgery. About 105 adults aged 21-60 having elective spine surgery will receive one of the two medicines right after surgery. Res…

This study compares two methods to help anxious patients complete an MRI scan: an infotainment system (like a TV) or hypnosis. Researchers will enroll 50 adults who feel unexpectedly anxious before a brain MRI. The goal is to see which approach helps patients stay calm enough to …

This study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people undergoing common urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults having these procedures for the first time will use the VR device during…

This study tests a two-week smartphone program designed to help people who struggle to feel pleasure (anhedonia) and also have high depression, anxiety, or stress. Participants do three short audio-guided exercises each day, focusing on gratitude, savoring positive moments, and f…

This study tests whether a 10-minute educational video can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to watch the video or receive only standard instructions. Researchers will measure anxiety level…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

This study tests whether a nutritional supplement called 'Think Tank' can improve thinking and memory in middle-aged women after they experience stress. Forty healthy women aged 40-60 will take either the supplement or a placebo and then complete cognitive tests. The goal is to s…

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia, a common stomach disorder. 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard treatment. The main goal is t…

This pilot study tests a wearable brain stimulation device called tACS for treating anxiety in up to 40 veterans under age 70. The device delivers low-intensity electrical pulses through scalp electrodes and can be used at home after an in-office training session. Over 8 weeks, r…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment manage stress and build resilience. Participants will use the app to learn skills to cope with difficult situations. The goal is to see which version …

This study tests whether an 8-session group therapy program, based on cognitive behavioural therapy (CBT) and adapted for Turkish culture, can help university students manage anxiety. Forty students from Bogazici University who have high anxiety scores will take part. The goal is…

This study tests if a four-week internet-based cognitive behavioral therapy (iCBT) program can reduce anxiety in people who struggle with MRI scans. Up to 60 participants will be randomly assigned to receive the therapy either before or after a simulated MRI. The goal is to see i…

This study is testing whether a short, guided breathing exercise (called cardiac coherence) can help reduce anxiety in people who are nervous about getting an MRI. Sixty adults who are anxious about their MRI will either do the breathing exercise or just read an information sheet…

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress, and improve memory and thinking skills in young adults. Researchers will enroll 135 university students aged 18 to 25 and measure changes in mood, cognitive function, and a brain-…

This study tests whether watching a virtual reality video about radiotherapy before treatment can lower anxiety in cancer patients. About 150 adults with cancer will be randomly assigned to see a standard 2D video, a first-person VR video, or a third-person VR video. Researchers …

This study tests whether a fun, group-based music training program can help underprivileged children aged 8-12 who are at risk for depression and anxiety. The program uses games to teach musical instruments, aiming to boost resilience and reduce emotional distress. Researchers wi…

This study tests a simple, drug-free technique called cutaneous resonance stimulation (RESC) to reduce anxiety in 62 people waiting for heart surgery. Researchers will measure how it affects the body's stress system and compare it to a fake version. The goal is to find a safe, no…

This study looks at whether reducing social media use and replacing that time with exercise, or practicing mindfulness, can help college students feel less anxious and depressed. About 300 students who use social media heavily will be split into three groups: one that does nothin…

This study tests a free 6-week online coaching program for NSU undergraduate students. The program aims to reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the study measures changes using standard …

This study tests a 10-week online group program for adults with spina bifida to improve self-esteem, quality of life, and reduce anxiety and depression. Participants join weekly video sessions with 6-7 others, plus two follow-ups. The goal is to strengthen social skills and emoti…

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This study tests whether letting children aged 3 to 5.5 watch a short 360-degree video of the clinic through VR goggles before their exam can reduce their fear and distress. Half of the 100 children will use the VR, while the other half will wait as usual. Researchers will measur…

This study tests whether a free online program from the World Health Organization, called 'Doing What Matters in Times of Stress,' can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress levels will eit…

This study tests whether an online, therapist-guided program for insomnia can also reduce anxiety symptoms. 98 adults with both chronic insomnia and anxiety will either start the program immediately or after a delay. The program includes sleep education, behavioural strategies, a…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether showing children an animated video of the procedure during pin removal can lower their pain and anxiety. About 120 kids aged 4 to 12 who had elbow fracture surgery will be randomly assigned to watch the video or not. Researchers will measure pain and anxi…

This study tests a virtual platform called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants get a care coordinator who recommends online treatments and works with their doctor. The goal is to see if this approach reduces symptoms better tha…

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

This study tests whether showing an interactive movie to children ages 2-6 during the start of anesthesia can lower their anxiety. About 70 kids having planned surgery will either get the movie distraction or standard care. Researchers will measure anxiety levels using a special …

This study tests an 8-week online cognitive behavioral therapy course designed for new and expecting parents struggling with anxiety or depression. Researchers will enroll 60 parents (including non-birthing partners) to see if the program reduces symptoms and is practical for rou…

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This study is testing whether low-intensity focused ultrasound (LIFU) — a noninvasive device that sends sound waves to the brain — can help people with chronic back pain, opioid cravings, and anxiety. Researchers will enroll 25 adults and measure safety, mood, heart rate, and oth…

This study tests two mind-body programs designed to reduce anxiety, depression, and emotional distress in cardiac arrest survivors and their caregivers. About 84 pairs (survivor and a family member or friend who helps them) will participate. The goal is to see if the programs are…

This study tests whether cognitive analytic therapy guided self-help (CAT-GSH) works as well as the standard cognitive behavioural therapy guided self-help (CBT-GSH) for people with anxiety or depression who are returning to NHS talking therapy services. About 100 participants wi…

This study tests whether doing five simple actions each day, with daily text reminders, can reduce symptoms of anxiety and depression. 410 adults in Norway with mild to moderate symptoms will be randomly assigned to the five-actions group, a gratitude group, or a waiting list. Th…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This study tests whether giving a small amount of the sedative midazolam during anesthesia can lower the risk of delirium (sudden confusion) and anxiety in older adults after surgery. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to r…

This study tests a 6-week, internet-based mindfulness program for adults with chronic tinnitus—a condition that can cause anxiety, depression, and poor quality of life. The program includes guided meditations and cognitive exercises, with no therapist support. Researchers will co…

This study tests a program called M-O-M-S on the Bayou, which pairs pregnant women with experienced mothers for support and classes. The goal is to reduce anxiety and depression in women living in areas hit by natural disasters. Researchers will recruit 240 pregnant women and tra…

This study tests whether a music therapy approach called therapeutic songwriting can improve mental health and social connections in university students who feel depressed, anxious, or stressed. Twenty participants will be randomly assigned to either four individual songwriting s…

This study tests whether wearing a virtual reality headset and noise-cancelling headphones during shock wave treatment for kidney stones can lower pain and anxiety. 72 adults scheduled for the procedure will be randomly assigned to either use VR or receive standard care alone. Th…

This study is testing a digital cognitive behavioral therapy program (SilverCloud) in Spanish, with added support from a peer coach, for Latino adults in San Francisco with depression or anxiety. 213 participants will either use the program on their own or with weekly check-ins f…

This study looks at a telephone-based program called SUSTAIN that helps older adults (65+) manage depression, anxiety, and chronic pain. Participants receive brief phone assessments and care management over 12 weeks. Researchers want to see what factors influence treatment succes…

This study tests a six-week group program delivered by phone or Zoom for adults 55 and older who feel lonely, isolated, or anxious. The program uses counseling techniques to help participants cope with difficult emotions and build connections. Researchers will compare the program…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which works better for autistic adults with depression and anxiety. About 300 participants from North Carolina and Virginia will receive therapy via teleheal…

This study tests whether a 6-week group class on nonviolent communication (NVC) can improve mental well-being in parents of primary-school children. About 172 parents with mild to severe anxiety or depression symptoms will be randomly assigned to take the class right away or wait…

This study tests whether a smartphone app that prompts physical activity can help adults with moderate depression feel better. Fifty participants will either use the app for four weeks or have their symptoms monitored without the app. Researchers will measure changes in depressiv…

This study tests whether a hypnosis session before and during a cardiac MRI can reduce anxiety and improve image quality. Researchers will compare anxious patients who receive hypnosis to those who do not, measuring how clear the images are and how many artifacts appear. If succe…

This study tests whether the JoyPop app can help 110 Canadian youth aged 12-17 better manage their emotions while on a waitlist for mental health services. Participants use the app at least twice daily alongside usual care. The goal is to see if the app improves emotion regulatio…

This study tests whether the JoyPop app can help 18-25 year olds in Northwestern Ontario better manage their emotions and reduce stress while they wait for mental health services. Participants will use the app at least twice daily and be compared to those receiving usual care. Th…

This study tests whether a midazolam nasal spray can quickly reduce acute anxiety in adults receiving palliative care. Participants will receive one of two doses of midazolam or a placebo spray. The main goal is to see if anxiety levels drop within 30 minutes, while also checking…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help reduce depression, anxiety, and stress in adults whose parents survived genocide. One hundred participants will receive a single 25mg dose under supervision, followed by …

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and su…

This study tests whether the JoyPop app can help Indigenous youth aged 18-25 in Northwestern Ontario manage their emotions and reduce stress while they wait for mental health services. Participants will use the app at least twice daily and be compared to those receiving usual car…

This study tests whether gentle massage (called 'relaxing touch') on the head, feet, and hands can reduce the need for calming drugs in sedated, intubated ICU patients as they wake up. About 72 adults will be randomly assigned to receive either standard care or extra massage twic…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study at the University of Pennsylvania is testing whether personalized brain stimulation can reduce negative emotions in people with depression and anxiety. Researchers will use brain scans to map each participant's negative emotion patterns, then apply different types of t…

This study looks at whether anxiety or depression makes asthma harder to control and aims to build a model that predicts when a serious asthma attack might happen. Researchers will follow 256 people with asthma for up to two years, tracking their symptoms, mental health, and lung…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study tests whether having a general practitioner and pharmacist work together can help people aged 65 and older safely stop or reduce benzodiazepines (drugs for sleep or anxiety). These medications raise the risk of falls, confusion, and dementia in older adults. The trial …

This study is looking at whether test anxiety during final exams is linked to bowel problems and constipation in university students. About 200 students will fill out questionnaires about their anxiety and digestive health. The goal is to better understand how mental stress might…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study investigates how the gut and brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety or depression. Researchers will compare 100 IBS patients with anxiety or depression to 100 healthy volunteers using brain scans, stool samples, and …

This study looks at anxiety levels in 100 living liver donors before and after their surgery. Participants will fill out questionnaires to measure their worry and stress. The goal is to better understand how anxiety affects recovery and to improve care for future donors.

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study examines whether climate anxiety is linked to suicidal thoughts and behaviors in young people aged 16 to 24 who are receiving psychiatric care. Researchers will use questionnaires to measure climate anxiety, general anxiety, and suicide risk in 108 participants. The go…

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study tests whether a brief, self-guided computer program can alter how people with anxiety and intolerance of uncertainty make decisions when outcomes are unclear. Researchers will measure changes in brain activity and decision-making before and after the 30-minute session.…

This study looks at how cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. Some see ads with mental health claims, others …

This study tests a community-wide program in Harlem that trains health workers and coordinates services to help Black and Latino adults with depression or anxiety. About 700 participants from low-income housing or primary care clinics will be involved. The goal is to see if this …

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study looks at 100 dental students to see if teeth grinding (bruxism), anxiety, and gum health are linked. Participants fill out anxiety questionnaires and get a gum exam. No treatment is given—just observation. The goal is to understand how stress might affect oral health i…

This study watches children aged 2 to 12 who are getting radiation therapy for cancer. Researchers want to see how their anxiety changes over time. The goal is to learn more about their emotional needs, not to test a new treatment.

This study looks at whether giving low-income adults aged 40 and older free meal kits and nutrition education can improve their food security, diet quality, mental health, and heart health. About 120 participants will be split into two groups: one gets meal kits plus nutrition cl…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study surveys 40 adults who have never had anesthesia before. They fill out a questionnaire before their low-risk surgery and answer follow-up questions a few days later. The goal is to see how their fear and anxiety change from before to after the experience. No drugs or tr…

Researchers at the University of Pittsburgh are testing whether a short, non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can alter emotional and physical responses to stress. Fifty-five healthy adults will receive both real and sham stimu…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study looks at whether patients who are more anxious before surgery are more likely to have a sudden drop in heart rate or blood pressure (vasovagal event) during spinal anesthesia. Researchers will measure anxiety levels in 1,500 adults aged 18-65 and track any such events.…

This study talks one-on-one with 30 adults who are anxious about their upcoming elective surgery. The goal is to learn exactly what worries them, so doctors can create better support plans and possibly prevent long-term pain after the operation. Participants will answer questions…

This observational study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression symptoms. The goal is to better understand brain fu…

This study looks at how getting older and feeling stressed can change the way we remember places and find our way around. Researchers will have 85 adults aged 65 to 80 do a virtual navigation task while their brains are scanned. Some participants will be put under mild stress to …

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study looks at how having social support (like a romantic partner) changes how alert and stressed we feel when facing possible threats. Researchers will use eye tracking to measure vigilance and arousal in 45 adults in stable relationships. The goal is to understand how past…

This study aims to validate a questionnaire that measures anxiety in cancer patients before surgery. Researchers will test the Italian version of the Surgical Anxiety Questionnaire (SAQ) with 180 adult patients. The goal is to better understand patients' fears and concerns so tha…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized ca…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will compare 50 healthy adults and 50 adults with social anxiety disorder. Participants will learn to associate a neutral image with a mild electr…

This study is testing whether a smartphone app can help firefighters improve their sleep, reduce stress, and boost thinking skills. About 50 firefighters will use the app and report how well it works. The goal is to see if the program is easy to use and helpful for real-life fire…

This study tests whether seeing a picture of a supportive friend or family member helps people with social anxiety unlearn fear more effectively. Researchers will compare fear responses in 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with e…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study explores whether dream yoga practices can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will learn techniques using virtual reality and home sleep monitors. The goal is to understand how these practices affect brain activity and dreaming, …

This study explores whether a non-invasive device placed in the outer ear can detect brain waves linked to anxiety, specifically the hippocampal theta rhythm. Researchers will give 42 healthy volunteers either buspirone, triazolam, or a placebo—drugs known to reduce these brain w…

This study tests a program called FRAME that helps heart failure patients discuss stress, anxiety, and depression with their doctors and loved ones. About 7,300 patients in Ontario, Canada will take surveys before and after using the tool. The goal is to see if the program makes …

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents and children dealing with anxiety, depression, and stress. About 80 parents of children aged 2-7 will complete surveys and provide saliva samples to measure oxytocin levels. The goal is to unders…

This study is developing a platform called CAMERA that uses wristband sensors and smartphone data to predict anxiety and memory states in people with epilepsy. Researchers will monitor 40 patients in the hospital to see how brain, body, and behavior signals relate. The goal is to…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This study looks at how thinking skills (like memory and focus) are linked to sick leave in people with depression or anxiety. Researchers will give metacognitive therapy with a work focus to 200 patients at risk of sick leave. They want to see if the therapy improves symptoms an…

This study tests whether teaching mindfulness and meditation to mothers with babies in the neonatal ICU can increase breastmilk volume and reduce stress. Forty mothers will be split into two groups: one gets standard care, the other adds mindfulness training. Researchers will mea…

This study looks at how women getting infertility treatment feel about artificial intelligence and how that relates to their anxiety and quality of life. About 191 women aged 18-45 who are currently undergoing treatment will answer surveys. The goal is to understand if attitudes …

This study tests whether a choice-driven, interactive storytelling web app can help Latinas with anxiety or depression start mental health treatment. Seven hundred participants in Los Angeles and Orange County will either use the story-based app or a control webpage with standard…

This study explores whether teachers can be trained to deliver mental health support to teenagers in rural India. About 216 students from 60 low-cost private schools will take part. The goal is to see if this approach is practical and effective for improving teen mental health.

This study looks at whether a recovery-focused program can help people with severe mental illness living in supported housing. About 72 participants will either receive the new program or standard care. The goal is to see if focusing on personal goals improves daily functioning a…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. It includes 3,600 adults who speak English or Spanish and have obesity, are due for colorectal or cervical cancer screening, o…

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…

This study looks at how having control over a virtual environment changes how people feel pain and anxiety. Twenty healthy adults will experience mild pain and anxiety in different virtual settings—some they can control, some they cannot. The goal is to understand how the brain a…

This study looks at whether thinking about death can increase feelings of depression and anxiety. Researchers will ask 128 adults to write about their thoughts on death or dental pain (as a control) and then measure their mood. The goal is to understand if fear of death plays a r…

This study is testing a program called Coffee and Family Education and Support (CAFES2) for refugee families from Arabic-speaking countries who have recently moved to Chicago. The program is led by trained peers and aims to improve mental health and family relationships. Research…

This study looks at how parents' tendency to see threats in everyday situations (interpretation bias) may influence their children's anxiety. Researchers will have 300 parents of children aged 7-12 use a smartphone app for four weeks to practice thinking less anxiously. The goal …

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This observational study follows 300 adults receiving strategic psychotherapy—a short-term, goal-focused talk therapy—in private practice. Participants fill out questionnaires about their symptoms and well-being before and after treatment. The goal is to see if this therapy leads…

This study is testing a mobile app called TrueBlue that automatically measures mood in pregnant women and new mothers. Researchers want to see if the app is safe, easy to use, and agrees with standard depression questionnaires. About 125 participants in Nottinghamshire, UK, will …

This study follows 540 adults with solid cancers to see how their anxiety and depression levels change over six months. Participants fill out questionnaires about their mood, coping, and quality of life at the start, 3 months, and 6 months. No drugs or treatments are given—the go…

This study examines how a park-based afterschool program called Fit2Lead affects the mental health, resilience, physical fitness, and violence prevention of teens aged 12-17 in Miami-Dade County. Researchers will analyze data from 1,000 participants to see changes in weight, bloo…

This study is looking for genetic markers linked to a side effect called behavioral activation—feeling overly excited or agitated—that can happen when children and youth take SSRI antidepressants for depression, anxiety, or OCD. Researchers will collect DNA from 160 participants …

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…

This study looks at how people with depressed mood, loss of interest, or anxiety respond to rewards and losses. Participants will play computer learning games and may have brain scans. The goal is to understand whether these responses are unique or overlapping, which could improv…

This study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…

This study follows 5,000 children in a Miami-Dade park-based after-school program called Fit2Play. The program includes daily physical activity and nutrition lessons. Researchers will track changes in weight, fitness, blood pressure, and mental health over time to see if the prog…